Results 141 to 150 of about 86,933 (255)

Characterizing Alzheimer’s Disease and Related Dementia in a Hypertension Population Within the State of Florida Using Electronic Health Record–Based Data

Clinical Pharmacology &Therapeutics, Volume 119, Issue 3, Page 751-762, March 2026.
Hypertension is a known modifiable risk factor for Alzheimer’s disease and related dementia (ADRD). However, it is unknown how variance in hypertension control, antihypertensive medications, and social determinants of health, such as social deprivation index (SDI), influence the risk of developing ADRD.
Eissa A. Jafari, Mona Alshahawey, Muhammad A. Zaman, Steven M. Smith, Yan Gong, Glenn E. Smith, Caitrin W. McDonough   +6 more
wiley   +1 more source

Subchronic Exposure to Aripiprazole Subtly Impacts on Rodents' Sperm Quality and Fertility

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 3, March 2026.
ABSTRACT Aripiprazole, a third‐generation antidepressant/antipsychotic drug, acts on serotonergic and dopaminergic receptors and is widely prescribed for mental disorders, such as depression and schizophrenia. Studies indicate that this class of drugs can impact directly on sperm quality and fertility.
Maria Joana Nogueira de Moura, Renata Gleysiane Sousa de Felix, Aline Gabriele Gomes da Silva, Ana Beatriz Silva Angelo, Caio César Araújo dos Santos, Artemia Kelly Holanda Pereira, Michelly Fernandes de Macedo, Cibele dos Santos dos Borges   +7 more
wiley   +1 more source

Identificação da variação em proteínas plasmáticas nas comunidades da Costa da Lagoa e de São João do Rio Vermelho, Ilha de Santa Catarina, Sul do Brasil

Biotemas, 1998
Identificamos, por eletroferese em gel de amido, a distribuição fenotípica das proteínas plasmáticas Albumina, Transferrina e Haptoglobina nas comunidades da Costa da Lagoa (CLG) e de São João do Rio Vermelho (SJRV).
Fabiana Cristiane da Rosa, Felipe A. Boff Maegawa, Ilíada Rainha de Souza   +2 more
doaj  

Literature‐informed ensemble machine learning for three‐year diabetic kidney disease risk prediction in type 2 diabetes: Development, validation, and deployment of the PSMMC NephraRisk model

Diabetes, Obesity and Metabolism, Volume 28, Issue 3, Page 1997-2026, March 2026.
Abstract Introduction Diabetic kidney disease (DKD) and diabetic nephropathy (DN) affect around 40% of diabetic patients but lack accurate risk prediction tools that include social determinants and demographic complexity. We developed and validated an ensemble machine learning model for three‐year DKD/DN risk prediction with deployment readiness ...
Ayla M. Tourkmani, Turki J. Al‐Harbi, Ahmad Abdullah Alghamdi, Ibrahim M. Youzghadli, Faris Saad Alosaimi, Ahmed Y. Azzam   +5 more
wiley   +1 more source

Age disparities in SGLT2 inhibitor prescription among people with type 2 diabetes: The role of frailty and sex

Diabetes, Obesity and Metabolism, Volume 28, Issue 3, Page 2265-2276, March 2026.
Abstract Background Older adults with type 2 diabetes (T2DM) are less likely to receive sodium–glucose cotransporter‐2 (SGLT2) inhibitors, despite their proven cardio‐renal benefits and safety. Whether this age‐related gap is driven by frailty, sex, or other factors remains unclear.
Changyuan Yang, Petra Denig, Lynne Chepulis, Ryan G. Paul, Jung‐Im Shin, Ron T. Gansevoort, Priya Vart   +6 more
wiley   +1 more source

Alpha‐Actinin‐3 Deficiency Links Genetic Susceptibility to Renal Fibrosis: Evidence From Hemodialysis Patients and Murine Models

The FASEB Journal, Volume 40, Issue 4, 28 February 2026.
This study links the ACTN3 R577X polymorphism to chronic kidney disease (CKD), specifically in patients undergoing hemodialysis (HD). In parallel, increased Actn3 expression in murine models of kidney injury supports a functional role for ACTN3 in renal pathophysiology.
Raisa B. Santos, Hellena Storch Vieira, Alice K. Scheer, Larissa R. Ribeiro, Cledia F. Silva, Rafael B. Orcy, Ines Schadock, Alexandre Budu, Ronaldo Carvalho Araujo, Augusto Schneider, André F. Rodrigues, Michael Bader, Maristela Böhlke, Carlos Castilho Barros   +13 more
wiley   +1 more source

Trends in first‐line monotherapy and combination therapy for hypertension in UK primary care

British Journal of Clinical Pharmacology, Volume 92, Issue 2, Page 457-467, February 2026.
Aims Debate remains about the optimal initial treatment strategy for hypertension. Most guidelines recommend first‐line combination therapy for most patients. However, the UK's National Institute for Health and Care Excellence recommends first‐line monotherapy for all patients.
Kyle Johnson, Sarah Beradid, James M. Brophy, Robert W. Platt, Christel Renoux   +4 more
wiley   +1 more source

Comparison of Interscalene Brachial Plexus, Anterior Suprascapular Nerve, and Costoclavicular Brachial Plexus Blocks in Arthroscopic Shoulder Surgery: A Prospective Observational Study. [PDF]

J Clin Med
Sarıoğlan BT, Kılıç Y, Sarıoğlan İE, Güleç MS.   +3 more
europepmc   +1 more source

Combination of cyclin-dependent kinase 4/6 inhibitors and renin-angiotensin system inhibitors in breast cancer treatment: a promising therapeutic approach. [PDF]

Rev Assoc Med Bras (1992)
Mutlu E, İnanç M.
europepmc   +1 more source

CCB website

Public website to communicate on the activities of the CCB and to be used as a platform to house useful resources for cohort-related research projects. Will include a members section for CCB members.
openaire   +1 more source