Results 31 to 40 of about 28,475 (220)
Micro-CT Imaging Reveals Mekk3 Heterozygosity Prevents Cerebral Cavernous Malformations in Ccm2-Deficient Mice. [PDF]
PLoS ONE, 2016 Mutations in CCM1 (aka KRIT1), CCM2, or CCM3 (aka PDCD10) gene cause cerebral cavernous malformation in humans. Mouse models of CCM disease have been established by deleting Ccm genes in postnatal animals.
Jaesung P Choi +7 more
doaj +1 more source
Frontiers in Physiology, 2022 Cardiac contractility modulation (CCM) is a medical device therapy whereby non-excitatory electrical stimulations are delivered to the myocardium during the absolute refractory period to enhance cardiac function.
Tromondae K. Feaster +7 more
doaj +1 more source
Advanced Functional Materials, EarlyView.A new electrochemical system based on a microporous hybrid of carbon nanoplatelets and nanotubes to selectively capture Ni2+ from wastewater is constructed. The system temperature rises rapidly when irradiated with sunlight, which enhances the Ni2+ removal rate by 250% and the selectivity by 53%, and the energy consumption is also reduced by 51 ...
Ziquan Wang +11 more
wiley +1 more source
Inflammatory Mechanisms in a Neurovascular Disease: Cerebral Cavernous Malformation
Brain Sciences, 2023 Cerebral cavernous malformation (CCM) is a common cerebrovascular malformation causing intracranial hemorrhage, seizures, and focal neurologic deficits.
Ying Li +9 more
doaj +1 more source
Structural Porosity and Low Mineral Density in Enamel Rods Drive Molar Incisor Hypomineralisation
Advanced Functional Materials, EarlyView.This study uses advanced imaging modalities on multiple length scales to show that molar‐incisor hypomineralization does not present as a locally homogeneous pathology. Instead, microstructural defects, characterized through non‐mineralized, protein‐rich sheaths and an altered mineral structure in between prism rods, resulting in local differences in ...
Katharina Jähn‐Rickert +14 more
wiley +1 more source
Advanced Functional Materials, EarlyView.Hydrocarbon membranes are a greener alternative to PFSA in PEM fuel cells, but degrade rapidly from radical attack. We present a novel strategy using poly(vinylphosphonic acid) (PVPA) as a local radical scavenger. Incorporated as an interfacial barrier, PVPA enhances chemical stability and significantly extends membrane lifetime under accelerated ...
Hendrik Sannemüller +6 more
wiley +1 more source
Adeno‐associated virus serotype 2 capsid variants for improved liver‐directed gene therapy
Hepatology, EarlyView., 2022 Abstract Background and Aims Current liver‐directed gene therapies look for adeno‐associated virus (AAV) vectors with improved efficacy. With this background, capsid engineering is explored. Whereas shuffled capsid library screenings have resulted in potent liver targeting variants with one first vector in human clinical trials, modifying natural ...
Nadja Meumann +25 more
wiley +1 more source
Frontiers in Psychiatry, 2021 Exposure to childhood trauma is a well-known risk factor for severe mental disorders including schizophrenia and other non-affective psychoses. Beyond childhood trauma, there is increasing evidence that bullying, social exclusion, and discrimination ...
Leonie Varchmin +4 more
doaj +1 more source
Ti6Al4V‐Bioglass‐Copper Composites for Load‐Bearing Implants
Advanced Healthcare Materials, EarlyView.We have designed and manufactured a novel Ti64‐based composite by adding 45S5 bioglass (BG) and copper (Cu). Adding BG on titanium improves wear resistance and biocompatibility, whereas Cu addition improves mechanical strength while providing inherent lifelong bacterial resistance.
Lochan Upadhayay +3 more
wiley +1 more source
Porous Iridium Oxide Inverse Opal Catalysts Enable Efficient PEM Water Electrolysis
Advanced Materials, EarlyView.Porous iridium‐based inverse opal (IrOx‐IO) structures are introduced as high‐performance, unsupported PEM‐WE anode catalysts. Their electrochemical behavior is analyzed through porosity/surface area tuning, voltage breakdown, and circuit modeling.
Sebastian Möhle +4 more
wiley +1 more source