Results 171 to 180 of about 180,784 (340)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

The culture of Remix in publications and republishings in CC BY, CC BY-SA and CC BY-NC.

, 2020
As licenças Creative Commons foram idealizadas para permitir a padronização de declarações de vontade no tocante ao licenciamento e distribuição de conteúdos culturais em geral (textos, músicas, imagens, filmes e outros), de modo a facilitar seu compartilhamento e recombinação, sob a égide de uma filosofia copyleft.
openaire   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Memorandum of agreement 2014 between CCS Logistics - City Deep and Food and Allied Workers Union

, 2014
Memorandum of agreement 2014 between CCS Logistics - City Deep and Food and Allied Workers ...
Food and Allied Workers Union, CCS Logistics - City Deep   +1 more
core  

Stabilizing the Extrinsic Porosity in Metal–Organic Cages-Based Supramolecular Framework by In Situ Catalytic Polymerization

CCS Chemistry, 2020
Liu, Guoliang, Zhou, Mi, Su, Kongzhao, Babarao, Ravichandar, Yuan, Daqiang, Hong, Maochun   +5 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Women's compliance with cervical cancer screening recommendations and associated barriers to participation: A cross-sectional analysis. [PDF]

PLoS One
Spriņģe L, Ķīvīte-Urtāne A, Tihomirova Ļ, Stars I, Mikule E, Žodžika J, Bukova-Žideļūna A, Pärna K, Nygard M, Uusküla A.   +9 more
europepmc   +1 more source

Advancing CCS in India: Policy Developments, Funding Mechanisms, and the Potential of Basalt Storage Solutions

Carbon Capture and Storage (CCS) is crucial for reducing emissions in hard-to-decarbonize sectors such as cement, steel, and power generation. For India, heavily reliant on coal, CCS provides a means to lower emissions while maintaining energy security ...
Kala, S., Lam, Y.
core