Results 21 to 30 of about 100,362 (261)

Coherence and correspondence in medicine [PDF]

open access: yesJudgment and Decision Making, 2009
Many controversies in medical science can be framed as tension between a coherence approach (which seeks logic and explanation) and a correspondence approach (which emphasizes empirical correctness).
Thomas G. Tape
doaj  

Changes in Central Corneal Thickness with Varying Post-prandial Blood Sugar Levels in Type 2 Diabetics [PDF]

open access: yesJournal of Clinical and Diagnostic Research, 2019
Introduction: Central Corneal Thickness (CCT) affects measurement of Intraocular Pressure (IOP) using Goldmann Applanation Tonometry (GAT). Variation in CCT with blood sugar levels in diabetics could affect IOP measurement and subsequent glaucoma ...
Dona George   +4 more
doaj   +1 more source

El entierro múltiple de Cabo Dos Bahías (Patagonia Central Argentina): recuperación de información de la colección Frengüelli-Brunet

open access: yesRevista del Museo de Antropologia, 2022
En este trabajo se presenta nueva información sobre el estudio interdisciplinario del entierro múltiple de Cabo Dos Bahías, ubicado en la costa norte del golfo San Jorge y excavado en 1984 por el Sr.
Ana Gabriela Millán   +4 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Attitudes and Beliefs Toward Computerized Cognitive Training in the General Population

open access: yesFrontiers in Psychology, 2020
IntroductionIn recent years, computerized cognitive training (CCT) programs have been developed commercially for widespread public consumption.
Vina M. Goghari   +6 more
doaj   +1 more source

Effect of diabetes mellitus on quantitative corneal anatomy – A systemic review

open access: yesAfrican Vision and Eye Health, 2022
Background: Corneal changes occur as a direct consequence of diabetes mellitus (DM). The central corneal thickness (CCT) is a useful parameter that provides information about the status of the metabolism of the cornea and can therefore help monitor the ...
Juan A. Sanchis-Gimeno   +4 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

A diferenciação entre os quadros depressivos com comprometimento cognitivo e demência nos idosos

open access: yesDebates em Psiquiatria, 2011
O transtorno depressivo no idoso apresenta uma alta taxa de prevalência e os critérios diagnósticos são similares ao transtorno depressivo nos adultos mais jovens.
E Castro-Costa, CCT Aguiar, SL Blay
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

open access: yesFEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji   +2 more
wiley   +1 more source

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