Results 21 to 30 of about 102,648 (260)

Rate of central corneal thickness changes in primary angle closure eyes: long-term follow-up results

open access: yesBMC Ophthalmology, 2021
Background Central corneal thickness (CCT) and its association with intraocular pressure, which is a pivotal parameter in glaucoma management, has previously been reported. In this study, we intended to investigate the long-term change of CCT in terms of
Hae Min Park   +3 more
doaj   +1 more source

Effect of diabetes mellitus on quantitative corneal anatomy – A systemic review

open access: yesAfrican Vision and Eye Health, 2022
Background: Corneal changes occur as a direct consequence of diabetes mellitus (DM). The central corneal thickness (CCT) is a useful parameter that provides information about the status of the metabolism of the cornea and can therefore help monitor the ...
Juan A. Sanchis-Gimeno   +4 more
doaj   +1 more source

Correlation between HbA1C and CCT in T2DM

open access: yesTNOA Journal of Ophthalmic Science and Research
An observational cohort study of central corneal thickness (CCT) in type 2 diabetes mellitus (T2DM) patients in hyperglycemic and euglycemic states. Context: To assess the significance of glycemic control in CCT measurement.
Krithika Chenthil   +2 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Attitudes and Beliefs Toward Computerized Cognitive Training in the General Population

open access: yesFrontiers in Psychology, 2020
IntroductionIn recent years, computerized cognitive training (CCT) programs have been developed commercially for widespread public consumption.
Vina M. Goghari   +6 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

open access: yesMolecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad   +2 more
wiley   +1 more source

A diferenciação entre os quadros depressivos com comprometimento cognitivo e demência nos idosos

open access: yesDebates em Psiquiatria, 2011
O transtorno depressivo no idoso apresenta uma alta taxa de prevalência e os critérios diagnósticos são similares ao transtorno depressivo nos adultos mais jovens.
E Castro-Costa, CCT Aguiar, SL Blay
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim   +4 more
wiley   +1 more source

Exploring the SiCCT Gene Family and Its Role in Heading Date in Foxtail Millet

open access: yesFrontiers in Plant Science, 2022
CCT transcription factors are involved in the regulation of photoperiod and abiotic stress in Arabidopsis and rice. It is not clear that how CCT gene family expand and regulate heading date in foxtail millet.
Congcong Li   +21 more
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

open access: yesFEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo   +6 more
wiley   +1 more source

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