Results 161 to 170 of about 220,756 (241)

Beyond the blood-brain barrier: humanised mice, the missing link in glioblastoma research. [PDF]

Oncogene
Shirazi Nia R, Lu J, De Vega D, Poudine N, Pan C, Zhou F, Ji J, Giamas G.   +7 more
europepmc   +1 more source

The FGF/FGFR System in the Biology and Therapeutic Landscape of Pediatric CNS Tumors

Medicinal Research Reviews, EarlyView.
ABSTRACT Central nervous system (CNS) tumors are the most common solid malignancies in children, comprising a highly heterogeneous group of neoplasms defined by distinct molecular alterations and clinical behaviors. Advances in molecular genetics have underscored the relevance of specific signaling pathways in driving pediatric tumorigenesis, among ...
Serena Filiberti, Camilla Tavani, Elena Somenza, Nicolas Tassone, Antonio d'Amati, Marta Turati, Roberto Ronca   +6 more
wiley   +1 more source

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

Reverse genetics in humanized mice reveals CARD8-mediated pyroptosis causing pancytopenia in human DPP9 deficiency. [PDF]

J Clin Invest
Xiao T, Brewer JR, Carlino M, Han A, Takabe YJ, Lee CY, Zhang F, Chen M, Blackburn HN, Nassar AH, Wang Q, Brennand K, Shan L, Sefik E, Krause DS, Flavell RA.   +15 more
europepmc   +1 more source

Prime editing in neuropsychiatric disorders: From mutation‐specific target selection to clinical translation

Neuroprotection, EarlyView.
Abstract Prime editing, a novel clustered regularly interspaced short palindromic repeats (CRISPR)‐based technology, fuses a reverse transcriptase (RT) to an engineered CRISPR‐associated protein 9 (Cas9) and uses a prime editing guide RNA (pegRNA)‐encoded template.
Tianshan Ji, Yuan Zhang, Jinyi Zhao, Yiping Lu, Chengkun Wang   +4 more
wiley   +1 more source

Keratoacanthoma‐Like Dermatofibroma: A Clinicodermoscopic Pitfall

JEADV Clinical Practice, EarlyView.
Mohammed Shanshal, Emily Moon, Mary Sisley   +2 more
wiley   +1 more source

In Utero HSC Transplantation for Sickle Cell Disease: A Potential Therapeutic Approach That Overcomes Complications of Current Therapies

Prenatal Diagnosis, EarlyView.
ABSTRACT Sickle cell disease (SCD) affects millions worldwide but has limited treatment options, most of which carry significant side effects. At present, the only curative treatment for SCD is allogeneic or gene‐modified autologous hematopoietic stem cell (HSC) transplantation (Tx).
Oluwaseun O. Babatunde, Madeleine G. Bibby, Anthony Atala, Graça Almeida‐Porada, Christopher D. Porada   +4 more
wiley   +1 more source

Optimizing Timing of Peripheral Blood Stem Cell Collection: A Comparative Study of Day-4 Versus Day-5 Post-G-CSF Mobilization in Healthy Allogeneic Donors. [PDF]

Biomedicines
Sarhan D, Alshwayyat S, Al-Wreidat RA, Alya H, Abdel Rahman Z, Ma'koseh M, Al-Hussaini M.   +6 more
europepmc   +1 more source

More Than a Birthmark? A Growing Pediatric Skin Lesion

JEADV Clinical Practice, EarlyView.
Shatha Ahmad Al Hajjaj, Sara Al Janahi, Shaden Abdelhadi   +2 more
wiley   +1 more source

Ex Vivo Study of the Vasomotor and Anti-Inflammatory Activity of Class 2 Elastic Venous Compression Devices Combined with Diosmetin-3-O-β-D-Glucuronide. [PDF]

Molecules
Belabed Y, Boisnic S, Stroumza N, Talbot CPJ, Molinard Y, Carrois F.   +5 more
europepmc   +1 more source