Results 271 to 280 of about 42,056 (305)

A nanodrug combining CD47 and sonodynamic therapy efficiently inhibits osteosarcoma deterioration.

Journal of Controlled Release, 2023
Treatments for osteosarcoma (OS) with pulmonary metastases reach a bottleneck with a survival rate of 10-20%. The suppressive tumor associated macrophages(TAMs) and CD47 over-expression greatly lead to the treatment failure. Sonodynamic therapy (SDT) can
Ming Gong, Yufeng Huang, Huixiong Feng, Jiaming Lin, Anfei Huang, Jin Hu, Q. Tang, Xiaojun Zhu, Shisong Han, Jinchang Lu, Jin Wang   +10 more
semanticscholar   +1 more source

EGFR Oncogenic Mutations in NSCLC Impair Macrophage Phagocytosis and Mediate Innate Immune Evasion Through Upregulation of CD47.

Journal of Thoracic Oncology
INTRODUCTION EGFR-mutated NSCLC is characterized by an immunosuppressive microenvironment that confers limited clinical effectiveness to anti-PD1/PD-L1 antibodies.
Li-Yang Hu, W-T. Zhuang, Maojian Chen, J. Liao, Dongyan Wu, Ya-Xiong Zhang, Lanlan Pang, Yi-Hua Huang, T.-Q. Mao, Meng-Juan Yang, Pei-Jian Peng, Jinxia Liang, Liang Chen, Linjuan Zeng, Li Zhang, W. Fang   +15 more
semanticscholar   +1 more source

A Twindrive Precise Delivery System of Platelet-Neutrophil Hybrid Membrane Regulates Macrophage Combined with CD47 Blocking for Postoperative Immunotherapy.

ACS Nano
During wound healing after cancer surgery, platelets, neutrophils, and macrophages accumulate at the wound site and induce important pathophysiological features.
Shupei Sheng, Limin Jin, Yan Zhang, Weiting Sun, Lin Mei, Dunwan Zhu, Xiaoning Dong, Feng Lv   +7 more
semanticscholar   +1 more source

Blocking CD47 promotes anti-tumor immunity through CD103+ dendritic cell-NK cell axis in murine hepatocellular carcinoma model.

Journal of Hepatology, 2022
BACKGROUND & AIMS CD47-signal regulatory protein α (SIRPα) axis inhibits dendritic cells (DCs) phagocytosis and contributes to the immune evasion. However, the behavior of DCs and the potential crosstalk between DCs and Natural Killer (NK) cells in the ...
Shuai Wang, Qinchuan Wu, Tianchi Chen, Rong Su, C. Pan, Junjie Qian, Hechen Huang, Shengyong Yin, Haiyang Xie, Lin Zhou, Shusen Zheng   +10 more
semanticscholar   +1 more source

Targeting the Cancer Biomarker CD47: A Review on the Diverse Mechanisms of the CD47 Pathway in Cancer Treatment

Anti-Cancer Agents in Medicinal Chemistry, 2016
CD47 is a widely expressed cell membrane receptor belonging to the immunoglobulin (Ig) superfamily. CD47 is involved in a number of cellular processes, including proliferation, apoptosis, adhesion and migration through interacting with integrin, thrombospondins and SIRPα. CD47 also plays an important role in the immune system and homeostasis. In recent
Liang, Zhang, He, Huang
openaire   +2 more sources

Implication of the CD47 pathway in autoimmune diabetes

Journal of Autoimmunity, 2010
CD47 and signal regulatory protein (SIRP) interactions have been proposed to take part in autoimmune disease susceptibility. Importantly, a recent genome-wide association study for type 1 diabetes susceptibility highlighted the association of the 20p13 region comprising the SIRP cluster, where some of the SIRP proteins encode functional ligands to CD47.
Véronique, Dugas, Claudine, Beauchamp, Geneviève, Chabot-Roy, Erin E, Hillhouse, Sylvie, Lesage   +4 more
openaire   +2 more sources

CD47 Signals T Cell Death

The Journal of Immunology, 1999
Abstract Activation-induced death of T cells regulates immune responses and is considered to involve apoptosis induced by ligation of Fas and TNF receptors. The role of other receptors in signaling T cell death is less clear. In this study we demonstrate that activation of specific epitopes on the Ig variable domain of CD47 rapidly ...
R D, Pettersen, K, Hestdal, M K, Olafsen, S O, Lie, F P, Lindberg   +4 more
openaire   +2 more sources

Deciphering the role of CD47 in cancer immunotherapy

Journal of Advanced Research
Immunotherapy has emerged as a novel strategy for cancer treatment following surgery, radiotherapy, and chemotherapy. Immune checkpoint blockade and Chimeric antigen receptor (CAR)-T cell therapies have been successful in clinical trials. Cancer cells evade immune surveillance by hijacking inhibitory pathways via overexpression of checkpoint genes. The
lan fang, Yufeng Shi, Yu'e Liu
exaly   +4 more sources

CD47 and thrombospondin-1 contribute to immune evasion by Porphyromonas gingivalis

Proceedings of the National Academy of Sciences of the United States of America
Significance Microbe-driven chronic inflammation in the oral cavity leads to periodontitis, a risk for systemic diseases. Porphyromonas gingivalis is a bacterial species that thrives alongside activated immune cells in periodontitis and has been linked ...
S. Angabo, K. Pandi, K. David, Orit Steinmetz, H. Makkawi, Maria Farhat, L. Eli-Berchoer, Nadeem Darawshi, Hiromichi Kawasaki, G. Nussbaum   +9 more
semanticscholar   +1 more source

Expression of CD47 protein in hematolymphoid neoplasms: Implications for CD47-mediated cancer immunotherapy

American Journal of Clinical Pathology
Abstract Objectives Recent studies show that blocking CD47-SIRPα interactions is a promising target in checkpoint inhibition for cancer immunotherapy. However, to date, the expression of CD47 is not well characterized in various hematolymphoid neoplasms.
Jingjing Zhang, Philip L Bulterys, Sebastian Fernandez-Pol, Sheren F Younes, Shuchun Zhao, Adnan Mansoor, Yasodha Natkunam   +6 more
openaire   +2 more sources