Results 311 to 320 of about 922,724 (383)

CD40 agonist improves the therapeutic efficacy of irreversible electroporation ablation for metastatic melanoma by promoting unexpected CD8⁺CD103⁺ cDC1 and TRM cell responses. [PDF]

Cancer Immunol Immunother
Wu Z, Yang Z, Iftikhar T, Groot G, Leary SC, Baniak N, Ahmed S, Bosch M, Moser M, Zhang W, Jiang J, Xiang J.   +11 more
europepmc   +1 more source

Stress‐Induced Activation of Prolactin‐NR4A1‐Midkine Axis Exacerbates Skin Inflammation

Advanced Science, EarlyView.
Chronic psychological stress activates prolactin signaling to reprogram dermal fibroblasts into APCDD1+ inflammatory effectors via NR4A1, driving midkine secretion. This paracrine hub amplifies keratinocyte proliferation and immune recruitment, thus exacerbating skin inflammation.
Zhiguo Li, Huiyi Quan, Wanting Liu, Jiaoling Chen, Mengyang Chu, Xin Tang, Ke Xue, Xuan Liu, Jingyi Ma, Yaxing Bai, Ruina Dong, Bing Li, Junfeng Hao, Wei Guo, Qingyang Li, Erle Dang, Johann E Gudjonsson, Gang Wang, Shuai Shao   +18 more
wiley   +1 more source

Neoadjuvant personalized viral vaccine prevents tumor relapse in checkpoint-resistant murine melanoma model. [PDF]

J Immunother Cancer
Seclì L, Nocchi L, Leoni G, Cotugno G, Troise F, Romano G, Busiello T, Micarelli E, Garzia I, Antonucci L, Scarselli E, D'Alise AM.   +11 more
europepmc   +1 more source

Targeting TNFRSF25 by agonistic antibodies and multimeric TL1A proteins co-stimulated CD8⁺ T cells and inhibited tumor growth

Xueyuan Lyu, Linlin Zhao, Sijia Chen, Yulu Li, Yajing Yang, Huisi Liu, Fang Yang, Wenhui Li, Jianhua Sui   +8 more
openalex   +1 more source

Targeting Mast Cell Activation and MIF‐Mediated Remodelling Enhances Chemotherapy Response in Pancreatic Cancer

Advanced Science, EarlyView.
Neoadjuvant gemcitabine plus nab‐paclitaxel (AG) reprograms pancreatic ductal adenocarcinoma by shifting malignant cells toward a classical phenotype and remodeling the tumor microenvironment. Despite enhancing cytotoxic NKT cells, AG activates tumor‐associated mast cells (TAMCs) and inflammatory CAFs through MIF signaling.
Libo Wang, Guangcong Shen, Guanpeng Xie, Zekun Li, Xiaoqing Ma, Mengyu Li, Ziyun Liu, Yadi Wang, Zongjing Lv, Qingxiao Fang, Huihui Sun, Ningning Zhao, Chao Yang, Tianxing Zhou, Yongjie Xie, Jun Yu, Jihui Hao   +16 more
wiley   +1 more source

The transcription factor ZEB2 mediates the antitumor efficacy of tumor-infiltrating lymphocytes in non-small cell lung cancer. [PDF]

Cell Death Dis
Wang J, Liu F, Li Y, Gao J, Yang S, Tian M, Deng L, Yang Y, Gong B, Zhao C, Gong H, Xie Z, Zhou Y, Huang R, Luo Q, Jiang D, Wang X.   +16 more
europepmc   +1 more source

Intrinsic MicroRNA‐10a Restricts Regulatory T Cell Suppressive Function and Intestinal Repair by Coordinating Transcriptional, Metabolic, and Epithelial Repair Pathways

Advanced Science, EarlyView.
This study identifies microRNA‐10a (miR‐10a) as a key brake on regulatory T cell (Treg) suppressive function and intestinal repair. By targeting Blimp‐1, Uqcrq, and amphiregulin, miR‐10a restrains transcriptional, metabolic, and epithelial programs essential for Treg activity.
Wenjing Yang, Tianming Yu, Hui Yang, Suxia Yao, Ruihua Ma, Elizabeth M Steinert, Karen M Ridge, Weiguo Cui, Navdeep S Chandel, Yingzi Cong   +9 more
wiley   +1 more source

Multimodal cell-cell communication driving CD8⁺ T cell dysfunction and immune evasion. [PDF]

Front Immunol
Chen L, Huang Q, Zhou P.
europepmc   +1 more source

Targeted Enrichment of Engineered Bacteria on Triple‐Negative Breast Cancer Turns Immunologically Cold Tumors Hot

Advanced Science, EarlyView.
In this study, an “all‐in‐one” engineered anaerobic bacterial system (PDAEcN/COS) is developed for the treatment of immunologically “cold” TNBC. This nanoplatform is capable of colonizing tumor cell surfaces and implementing “self‐blocking” of immune checkpoints, while simultaneously suppressing tumor cells' “don't eat me” signals and delivering “eat ...
Xuanxiang Zhai, Xiaoyi Shi, Xiao Liu, Xiaotong Gu, Wenting Li, Xiangjun Chen, Wei Hong   +6 more
wiley   +1 more source

L-Tetrahydropalmatine synergizes cytotoxic CD8⁺ T mediated antitumor and ferroptosis in gastric cancer. [PDF]

Cell Death Discov
Zhou L, Wei Y, Lin K, Lu Y.
europepmc   +1 more source