Results 341 to 350 of about 922,724 (383)
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Polymorphism of chicken CD8-alpha, but not CD8-beta
Immunogenetics, 1997We report here the structural basis of CD8 polymorphism in the chicken. Three chicken strains (RPRL Line 7, H.B15.H7, and H.B15. H12) have 14 nucleotide differences in the CD8A cDNA sequence causing eight amino acid replacements in the extracellular part of the molecule.
M, Luhtala +3 more
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Granzyme K+ CD8 T cells form a core population in inflamed human tissue
Science Translational Medicine, 2022T cell–derived pro-inflammatory cytokines are a major driver of rheumatoid arthritis (RA) pathogenesis. Although these cytokines have traditionally been attributed to CD4 T cells, we have found that CD8 T cells are notably abundant in synovium and make ...
A. Jonsson +19 more
semanticscholar +1 more source
CD8+ cytotoxic T lymphocytes in cancer immunotherapy: A review
Journal of Cellular Physiology, 2018CD8+ cytotoxic T lymphocytes (CTLs) are preferred immune cells for targeting cancer. During cancer progression, CTLs encounter dysfunction and exhaustion due to immunerelated tolerance and immunosuppression within the tumor microenvironment (TME), with ...
Bagher Farhood, M. Najafi, K. Mortezaee
semanticscholar +1 more source
Science Immunology, 2023
Iterative acute stimulations can maintain CD8 T cells for longer than their organismal lifespan.
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Iterative acute stimulations can maintain CD8 T cells for longer than their organismal lifespan.
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Current Opinion in Immunology, 2005
Mounting evidence shows that CD8(+) T cells contribute to the initiation, progression and regulation of several pathogenic autoimmune responses in which these cells were not previously thought to play a major role. CD8(+) T cells can kill target cells directly, by recognizing peptide-MHC complexes on target cells, or indirectly, by secreting cytokines ...
Ulrich, Walter, Pere, Santamaria
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Mounting evidence shows that CD8(+) T cells contribute to the initiation, progression and regulation of several pathogenic autoimmune responses in which these cells were not previously thought to play a major role. CD8(+) T cells can kill target cells directly, by recognizing peptide-MHC complexes on target cells, or indirectly, by secreting cytokines ...
Ulrich, Walter, Pere, Santamaria
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AIDS Research and Human Retroviruses, 1999
The distribution and function of lymphocytes vary in different clinical states. The object of this study was to characterize the CD8+ lymphocyte subpopulations and CD8+ anti-HIV suppressor activity in HIV-infected and uninfected pregnant and nonpregnant women.
K C, Rich +4 more
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The distribution and function of lymphocytes vary in different clinical states. The object of this study was to characterize the CD8+ lymphocyte subpopulations and CD8+ anti-HIV suppressor activity in HIV-infected and uninfected pregnant and nonpregnant women.
K C, Rich +4 more
openaire +2 more sources
Critical Reviews in Immunology, 2003
Aging of the immune system, or "immunosenescence," is associated with both a marked reduction in responsiveness as well as functional dysregulation. These changes have been implicated in the increased morbidity and mortality of the elderly population from infectious disease, and may also play a role in autoimmunity and cancer.
Rita B, Effros +2 more
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Aging of the immune system, or "immunosenescence," is associated with both a marked reduction in responsiveness as well as functional dysregulation. These changes have been implicated in the increased morbidity and mortality of the elderly population from infectious disease, and may also play a role in autoimmunity and cancer.
Rita B, Effros +2 more
openaire +2 more sources
Seminars in Immunology, 2004
This review describes what is generally known about CD8 immune responses, and focus in the most recent advances in this domain. It also attempts to point to the areas where experimental evidence is contradictory or insufficient, and thus require further exploration and clarification.
B, Rocha, C, Tanchot
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This review describes what is generally known about CD8 immune responses, and focus in the most recent advances in this domain. It also attempts to point to the areas where experimental evidence is contradictory or insufficient, and thus require further exploration and clarification.
B, Rocha, C, Tanchot
openaire +2 more sources
The Journal of Immunology, 2017
Abstract Autoimmune diseases such as type I diabetes (TID) and multiple sclerosis (MS) are chronic conditions that have a significant impact on quality of life. CD8+ T-cells play an important role in the pathogenesis of these diseases. However, drugs that target the entire CD8+ T-cell population are not desirable because this population ...
Linda Wooldridge +19 more
openaire +1 more source
Abstract Autoimmune diseases such as type I diabetes (TID) and multiple sclerosis (MS) are chronic conditions that have a significant impact on quality of life. CD8+ T-cells play an important role in the pathogenesis of these diseases. However, drugs that target the entire CD8+ T-cell population are not desirable because this population ...
Linda Wooldridge +19 more
openaire +1 more source