Results 351 to 360 of about 922,724 (383)
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2004
Publisher Summary The term “effector cell” best describes differentiated T cells with immediate TcR-triggered cytotoxicity or cytokine secretion, as detected in short-term assays, which are currently only feasible in vitro. Investigators agree that antigen recognition by naive CD8+ T cells does not result in either type of effector function (the IL-2
Pierre A, Henkart, Marta, Catalfamo
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Publisher Summary The term “effector cell” best describes differentiated T cells with immediate TcR-triggered cytotoxicity or cytokine secretion, as detected in short-term assays, which are currently only feasible in vitro. Investigators agree that antigen recognition by naive CD8+ T cells does not result in either type of effector function (the IL-2
Pierre A, Henkart, Marta, Catalfamo
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cGAS-STING–mediated DNA sensing maintains CD8+ T cell stemness and promotes antitumor T cell therapy
Science Translational Medicine, 2020Cell-intrinsic cGAS-STING–mediated DNA sensing promotes the formation of stem cell–like CD8+ T cells for effective cancer T cell therapy. Intuitive CD8+ T cells sense DNA Stimulator of interferon genes (STING) agonism is an area of active exploration for
Wenwen Li +16 more
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Nature Reviews Immunology, 2019
A mix of 11 strains of commensal bacteria is shown to specifically induce potent antimicrobial and antitumour IFNγ-producing CD8+ T cells in mice.
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A mix of 11 strains of commensal bacteria is shown to specifically induce potent antimicrobial and antitumour IFNγ-producing CD8+ T cells in mice.
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Seminars in Immunopathology, 2019
CD8+ T cells are important for the protective immunity against intracellular pathogens and tumor. In the case of chronic infection or cancer, CD8+ T cells are exposed to persistent antigen and/or inflammatory signals. This excessive amount of signals often leads CD8+ T cells to gradual deterioration of T cell function, a state called "exhaustion ...
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CD8+ T cells are important for the protective immunity against intracellular pathogens and tumor. In the case of chronic infection or cancer, CD8+ T cells are exposed to persistent antigen and/or inflammatory signals. This excessive amount of signals often leads CD8+ T cells to gradual deterioration of T cell function, a state called "exhaustion ...
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Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH
Nature, 2021M. Dudek +47 more
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IL-2 regulates tumor-reactive CD8+ T cell exhaustion by activating the aryl hydrocarbon receptor
Nature Immunology, 2021Yuying Liu +26 more
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Restoring function in exhausted CD8 T cells during chronic viral infection
Nature, 2006Daniel L. Barber +7 more
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The Structure of the CD4 and CD8 Genes
Annual Review of Immunology, 1987The CD4 and CD8 glycoproteins are nonpolymorphic members of the immunoglobulin gene superfamily which are expressed on the surface of functionally distinct populations of T lymphocytes. These molecules, also known respectively as T4/Leu3 and T8/Leu2 in human, and as L3T4 and Lyt2/Lyt3 in mouse, appear to be essential for effective cell-cell inter ...
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