Results 131 to 140 of about 256,000 (308)

Inhaled Angiopoietin‐Like 4 Antisense Oligonucleotide Therapy for Lung Injury and Fibrosis

Advanced Science, EarlyView.
Inhaled antisense oligonucleotides targeting ANGPTL4 attenuate inflammation, preserve barrier integrity, and reduce fibrosis in both infectious and sterile lung injury models. Integrated transcriptomic analysis reveals a conserved ANGPTL4‐regulated gene network coordinating hypoxic, inflammatory, apoptotic, and stress‐response pathways.
Haiyang Fan, Yuanyang Tan, Junhang Zhang, Xiaoya Liu, Jing Qu, Damien Chua, Hong Sheng Cheng, Joseph Han Sol Kim, Yu Xuan Liu, Changfei Qin, Yingzi Liu, Dezhi Li, Jikang Qiu, Mengshi Chi, Mingmin Bi, Qiwei Zhang, Yun Li, Masoumeh Motamedi Joibari, Stefan K Nilsson, Nguan Soon Tan, Yunping Fan, Liang Li   +21 more
wiley   +1 more source

Immunopeptidomics identified antigens for mRNA-lipid nanoparticle vaccines with alpha-galactosylceramide in multiple myeloma therapy

Journal for ImmunoTherapy of Cancer
Background Invariant natural killer T (iNKT) cells and CD8+ T cells are key in the immune response against multiple myeloma (MM), a largely incurable blood cancer. Immunization is a promising strategy to activate these T cell populations.
Eline Menu, Lorenzo Franceschini, Karin Vanderkerken, Elke De Bruyne, Karine Breckpot, Kim De Veirman, Arne Van der Vreken, Fabien Thery, Chenggong Tu, Kevin Mwangi, Sofie Meulewaeter, Lien De Beck, Edith Janssens, Francis Impens, Rein Verbeke, Ine Lentacker   +15 more
doaj   +1 more source

IRF4 links antigen affinity to CD8⁺ T‐cell metabolism [PDF]

Immunology & Cell Biology, 2013
The affinity of the T-cell receptor (TCR) for antigen is central to determining T-cell fate both during development in the thymus and during peripheral activation and differentiation. While some differential signaling has been described between low- and high-affinity TCR-antigen interactions, the mechanisms through which antigen affinity determine T ...
openaire   +2 more sources

Substantially Altered Local and Systemic Immunity in Ischemia‐Free Versus Conventional Liver Transplantation

Advanced Science, EarlyView.
This study investigates how ischemia‐free liver transplantation (IFLT) shapes both local and systemic immune responses compared with conventional liver transplantation (CLT). Our findings demonstrate that IFLT confers significant immunological protection by attenuating the STAT3‐HIF‐1α axis and enhancing the Heme‐HMOX1 pathway, two regulatory networks ...
Tao Luo, Shuai He, Shirui Chen, Dongmei Ye, Shibo Zhang, Di Liu, Dawei Zou, Linhe Wang, Huadi Chen, Jinghong Xu, Huanjie Liu, Ruiting Liu, Xi Tan, Yitong Wang, Jiayi Zeng, Runbing Mo, Yuexin Li, Yuyi Zhang, Tanyiyang Ruan, Tielong Wang, Zehua Jia, Yu Jia, Tongdi Fang, Yimou Lin, Xiaorui Liu, Yunhua Tang, Maogen Chen, Qiang Zhao, Anbin Hu, Weiqiang Ju, Yi Ma, Dongping Wang, Xiaofeng Zhu, Schlegel Andrea, Yuan Zhai, Kwan Man, Tullius G. Stefan, Yifang Gao, Jinxin Bei, Xiaoshun He, Zhiyong Guo   +40 more
wiley   +1 more source

Enhancing Natural Killer and CD8 + T Cell-Mediated Anticancer Cytotoxicity and Proliferation of CD8 + T Cells with HLA-E Monospecific Monoclonal Antibodies [PDF]

, 2019
Cytotoxic NK/CD8+ T cells interact with MHC-I ligands on tumor cells through either activating or inhibiting receptors. One of the inhibitory receptors is CD94/NKG2A.
Asgharzadeh, Shahab, Devarajan, Asokan, Filippone, Edward J., Ravindranath, Mepur H.   +3 more
core   +1 more source

Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors

Advanced Science, EarlyView.
Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen, Scott R Walsh, Li Deng, Lan Chen, Yonghong Wan   +4 more
wiley   +1 more source

Archaeosome Adjuvant Overcomes Tolerance to Tumor-Associated Melanoma Antigens Inducing Protective CD8+ T Cell Responses

Clinical and Developmental Immunology, 2010
Vesicles comprised of the ether glycerolipids of the archaeon Methanobrevibacter smithii (archaeosomes) are potent adjuvants for evoking CD8+ T cell responses.
Lakshmi Krishnan, Lise Deschatelets, Felicity C. Stark, Komal Gurnani, G. Dennis Sprott   +4 more
doaj   +1 more source

Dendritic cells in plasmodium infection [PDF]

, 2008
Infection with Plasmodium parasites (malaria) contributes greatly to morbidity and mortality in affected areas. Interaction of the protozoan with the immune system has a critical role in the pathogenesis of the disease, but may also hold a key to ...
Alonso, Bejon, Britta C Urban, Bruna-Romero, deWalick, Greenwood, Park, Patel, Perry, Pichyangkul, Pouniotis, Skorokhod, Stephen M Todryk, Todryk, Wong, Wykes   +15 more
core   +2 more sources

FAPα+ Macrophages Orchestrate Immune Evasion in Multiple Myeloma by Dual Regulation of PD‐L1 and T Cell Senescence

Advanced Science, EarlyView.
Fibroblast activation protein alpha‐positive (FAPα+) macrophages, a distinct subset of multiple myeloma (MM)‐associated macrophages, drive immune evasion in MM through multi‐faceted mechanisms. FAPα physically interacts with vimentin (VIM) and triggers its phosphorylation at the S72 residue, which in turn induces PD‐L1 transcription. Additionally, FAPα
Huiyao Gu, Zhenfeng Dai, Xi Huang, Enfan Zhang, Xinyuan Dai, Haoguang Chen, Wen Cao, Jinna Zhang, Yifan Hou, Haimeng Yan, Yang Yang, Li Yang, Yi Li, Wenlong Lin, Zhen Cai, Jingsong He   +15 more
wiley   +1 more source

Identification of a CD4+ T cell-stimulating antigen of pathogenic bacteria by expression cloning. [PDF]

, 1995
Identifying the immunogenic proteins that elicit pathogen-specific T cell responses is key to rational vaccine design. While several approaches have succeeded in identifying major histocompatibility complex (MHC) class I bound peptides that stimulate CD8+
Campbell, D, Sanderson, S, SHASTRI, Nilabh   +2 more
core   +1 more source