Results 101 to 110 of about 54,840 (264)

Red lines and green lights: Gene therapy for inherited erythroid disorders beyond the haemoglobinopathies

open access: yesBritish Journal of Haematology, EarlyView.
Gene therapy is revolutionizing treatment paradigms for haemoglobinopathies, establishing a translational framework for disorders that impact red blood cell development. In their paper, Joshi et al. describe the preclinical and early clinical landscape of gene therapies for non‐haemoglobinopathy erythroid disorders and highlight common thematic ...
Gaurav Joshi   +3 more
wiley   +1 more source

Identifiability conditions in cognitive diagnosis: Implications for Q‐matrix estimation algorithms

open access: yesBritish Journal of Mathematical and Statistical Psychology, EarlyView.
Abstract The Q‐matrix of a cognitively diagnostic assessment (CDA), documenting the item‐attribute associations, is a key component of any CDA. However, the true Q‐matrix underlying a CDA is never known and must be estimated—typically by content experts.
Hyunjoo Kim   +2 more
wiley   +1 more source

Evidence That the Protein Phosphatase Activity of PTEN Contributes to Embryonic Development and Tumor Suppression

open access: yesCancer Science, EarlyView.
Mice expressing only mutant PTEN Y138L, a protein which shows normal suppression of cellular AKT yet lacks protein phosphatase activity, die in utero, and heterozygous mice display a range of tumors. This indicates both the lipid and protein phosphatase activities of PTEN work together for normal tumor suppression and embryonic development.
Priyanka Tibarewal   +16 more
wiley   +1 more source

How Do LLMs See Charts? A Comparative Study on High‐Level Visualization Comprehension in Humans and LLMs

open access: yesComputer Graphics Forum, EarlyView.
Abstract Designers often create visualizations to achieve specific high‐level analytical or communication goals. These goals require people to extract complex and interconnected data patterns. Prior perceptual studies of visualization effectiveness have focused on low‐level tasks, such as estimating statistical quantities, and have recently explored ...
Hyotaek Jeon   +8 more
wiley   +1 more source

SiGnature: Explicit Motion Diffusion for Stylized Semantic Gesture Generation

open access: yesComputer Graphics Forum, EarlyView.
Abstract While recent advances in co‐speech gesture generation have achieved impressive rhythmic synchronization, synthesizing gestures that are both semantically meaningful and faithful to a speaker's unique non‐verbal style remains an open challenge.
Adi Rosenthal   +4 more
wiley   +1 more source

EL PENTECOSTALISMO DE LAS ASAMBLEAS DE DIOS EN CARTAGENA * ORÍGENES HISTÓRICOS DE UN NUEVO SISTEMA RELIGIOSO POPULAR (1970-1972)

open access: yesRevista Cultura & Religión, 2012
Este artículo pretende identificar los orígenes históricos de la llegada del pentecostalismo Asambleas de Dios a la ciudad de Cartagena de Indias entre los años de 1970 y 1972.
José María Pérez
doaj  

The (In)visibility of the SDGs in Students' Learning in England: Evidence From Focus Groups With 15‐Year‐Olds

open access: yesChildren &Society, EarlyView.
ABSTRACT Within the English key stage four curriculum, where pupils are preparing for standardised assessment at age 16, many subjects include content pertinent to the Sustainable Development Goals (SDGs). However, due to the assessment focus and exam content of this educational phase, these are rarely explicitly referenced or discussed.
Penelope Williams, Gwadabe Kurawa
wiley   +1 more source

Migrant Motherhood and Child Protection: The Ecuador–Genoa Case

open access: yesChildren &Society, EarlyView.
ABSTRACT Migrant motherhood is often accompanied by a dual stigma, both in the country of origin and that of migration, where migrant mothers are frequently associated with a failure to parent adequately. Drawing on a case study of Latin migration in Genoa (Italy), this article examines the phenomenon in relation to the dynamics of the globalised ...
Francesca Lagomarsino, Chiara Lanini
wiley   +1 more source

Phylogenetic and ecological duality in the otoliths of Sciaenidae

open access: yesCladistics, EarlyView.
Abstract Teleost fishes have evolved taxon‐specific otoliths that vary greatly in size and shape and are primarily involved in hearing and balance. This study identifies the main drivers of otolith shape disparity in Sciaenidae, a clade of sound‐producing bony fishes, using three‐dimensional geometric morphometrics (3DGM).
Dominique Mediodia   +3 more
wiley   +1 more source

HIV‐associated nephropathy: A decade of clinical outcomes, global disparities and emerging promise

open access: yesHIV Medicine, EarlyView.
Abstract Objective To review the pathogenesis, epidemiology, clinical presentation, management and outcomes of HIV‐associated nephropathy (HIVAN), with emphasis on global disparities, genetic susceptibility (APOL1) and emerging therapeutic and technological advances.
Deepak V. Pathiyil   +4 more
wiley   +1 more source

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