Results 131 to 140 of about 330,731 (313)

Clinical Model‐Informed Precision Dosing Consult Service for Accelerating Personalized Medication in Pediatric Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Traditional dosing strategies often rely on a “one‐size‐fits‐all” paradigm, assuming an “average” patient with typical demographic and pharmacological characteristics. In reality, this often overlooks existing between‐patient variability and can lead to suboptimal drug exposure or toxicity. This issue is especially pronounced in pediatric patients, who
Zachary L. Taylor, Takanobu Nadai, Kei Irie, Wen Rui Tan, Sanjana Parikh, Anhar Hosawi, Matthijs W. van Hoogdalem, Ronaldo Morales Junior, Sonya Tang Girdwood, Abbie D. Leino, Kana Mizuno, Alexander A. Vinks, Tomoyuki Mizuno   +12 more
wiley   +1 more source

NAFLD/MASLD, including cirrhosis: Burden from 1990 to 2040, GBD decomposition, CDC WONDER analysis, and machine-learning attribution

Luna Zhao, Bingjie Li, Xi Zhang, Jinbao Liu, Jingkun Li, Hanwen Zhang, Kexin Cui, Junhao Ma, Fangyi Zhao, 朱庆峰   +9 more
openalex   +1 more source

Pharmacokinetics of Rifapentine and Desacetyl Rifapentine in Maternal Plasma and Breast Milk & Infant Cord Blood and Plasma: A Model‐Based Analysis of Mother–Infant Pairs for Tuberculosis Prevention

Clinical Pharmacology &Therapeutics, EarlyView.
IMPAACT 2001 (NCT02651259) evaluated the safety and pharmacokinetics (PK) of once‐weekly isoniazid and rifapentine in pregnant and postpartum women for tuberculosis prevention. Rifapentine (RPT) and desacetyl rifapentine (desRPT) PK data were collected in maternal plasma, breast milk, infant cord blood, and infant plasma.
Priya Jayachandran, Jyoti S. Mathad, Nan Zhang, Paula Britto, Lubbe Wiesner, Grace Montepiedra, Jennifer Norman, Ellen Townley, Sarah Bradford, Sandesh Patil, Stephanie Popson, Tsungai Chipato, Vanessa Rouzier, Deborah Langat, Amphan Chalermchockcharoentkit, Amita Gupta, Kelly E. Dooley, Radojka Savic, on behalf of the IMPAACT 2001 Study Team   +18 more
wiley   +1 more source

Immunotherapy in Bellini Duct Carcinoma: A Systematic Review. [PDF]

Oncol Res
Lázaro-Sánchez AD, Benítez-Fuentes JD, Wikström-Fernández S, Nevado-Rodríguez M, Conesa-Zamora P, Luengo-Gil G, Ivars-Rubio A, Zafra-Poves M, Carosella ED, Fernández-Molina B, Nieto-Olivares A, Sánchez de Las Matas Garre MJ, Arroyo AB.   +12 more
europepmc   +1 more source

Threats to Public Health and Scientific Infrastructures Threaten Progress in Eating Disorder Research, Treatment, and Prevention: A Call to Action for the Field

International Journal of Eating Disorders, EarlyView.
ABSTRACT The US federal government has enacted sweeping policy changes since January 2025 that imperil public health, with important implications for the eating disorders field—a field that is already disproportionately under‐resourced. This paper examines the pathways through which these recent policy changes threaten progress in eating disorder ...
Ariel L. Beccia, Lilian P. Palmer, Bek Urban, Amanda Raffoul   +3 more
wiley   +1 more source

Converging burdens of ischemic and hemorrhagic stroke: global co-burden trends (GBD 2023), death-certificate co-listing in the United States (CDC WONDER 1999–2024), and drug-target Mendelian randomization

Dehan Liu
openalex   +1 more source

Proportion, Five‐Year Survival Rate of Laryngeal Cancer and Its Associated Factors Among Head and Neck Cancer Patients in Tanzania

Eye &ENT Research, EarlyView.
ABSTRACT Background Laryngeal cancer carries a significant global burden, with substantial morbidity and mortality, and is increasing globally, with 95%–98% being squamous cell carcinoma. Males are more affected than females, with peak cases occurring between 60 and 80 years of age.
Amenye Adili, Furaha Serventi, Baraka M. Musimu, Mica Magembe, Orest Tarimo, Geofrey Ikelesho, Salum Kalonge, Leonard Kiboko, Queen Godfrey Tarimo, Desderius C. Chussi   +9 more
wiley   +1 more source

Trends and disparities in sepsis-related mortality among patients with lung cancer in the United States: CDC WONDER 1999 to 2023

Gang Chen, Qinzhi Liu, Zhenjiang Li
openalex   +1 more source

Treatment and outcome of chronic disseminated candidiasis in the era of antifungal prophylaxis: a retrospective multicentre cohort of 111 patients. [PDF]

EClinicalMedicine
Reinhold I, Ramirez-Sanchez IC, Chen PY, Chen YC, Dhariwal A, Lambourne J, Agrawal S, Bastida M, Gudiol C, Alfandari S, Di Pilla A, Khostelidi S, Aguilar-Zapata D, Barac A, Cipriano A, Ehrlich S, Grothe J, Illarramendi J, Jennrich S, Khedr R, Leotta D, Méndez GA, Nacov JA, Nagao M, Saydam G, Schwartz S, Steinmann J, Arn K, Enoch DA, Föhring D, Joean O, Koehler P, Krause R, Maertens J, Marchesi F, Onyeaghala C, Stone N, Vanbiervliet Y, Wolfensberger N, Haensel L, Hurraß J, Panse J, Sal E, Stemler J, Bové DS, Sprute R, Minero MV, Vena A, Pagano L, Cornely OA, Seidel D, FungiScope® Working Group of the European Confederation of Medical Mycology (ECMM) and the International Society for Human and Animal Mycology (ISHAM);, Fungal Infections Study Group of the European Society of Clinical Microbiology and Infectious Diseases (EFISG) and the ESCMID Study Group for Infections in Compromised Hosts (ESGICH).   +52 more
europepmc   +1 more source

Cardiogenic shock mortality according to Aetiology in a Mediterranean cohort: Results from the Shock‐CAT study

ESC Heart Failure, Volume 12, Issue 2, Page 1336-1345, April 2025.
Abstract Aims Mortality in cardiogenic shock (CS) remains elevated, with the potential for CS causes to impact prognosis and risk stratification. The aim was to investigate in‐hospital prognosis and mortality in CS patients according to aetiology. We also assessed the prognostic accuracy of CardShock and IABP‐SHOCK II scores.
Cosme García‐García, Teresa López‐Sobrino, Esther Sanz‐Girgas, Maria R. Cueto, Jaime Aboal, Pablo Pastor, Irene Buera, Alessandro Sionis, Rut Andrea, Judit Rodríguez‐López, Jose Carlos Sánchez‐Salado, Carlos Tomas, Jordi Bañeras, Albert Ariza, Josep Lupón, Antoni Bayés‐Genís, Ferran Rueda, Grup de Treball de Cures Agudes Cardiològiques Societat Catalana de Cardiologia   +17 more
wiley   +1 more source