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CDC20 assists its catalytic incorporation in the mitotic checkpoint complex
Science, 2021Checking fidelity in cell division Everything has to go right during cell division, so a checkpoint mechanism known as the spindle-assembly checkpoint prevents mitosis from proceeding unless the kinetochores that attach chromosomes to the spindle ...
V. Piano +7 more
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Under arrest in mitosis: Cdc20 dies twice
Nature Cell Biology, 2008The spindle assembly checkpoint is crucial for maintaining genome integrity in dividing cells by preventing premature chromosome segregation. Degradation of the APC/C activator Cdc20 seems to be an essential and conserved mechanism to maintain this checkpoint in the presence of chromosomes that are not attached to the mitotic spindle.
Fry, AM, Yamano, H
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Cdc20-APC in Synapse Formation
Science, 2009The ubiquitin ligase Cdc20-APC is required for proper synapse formation in the developing rat brain.
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Regulation of APC–Cdc20 by the spindle checkpoint
Current Opinion in Cell Biology, 2002The spindle checkpoint ensures the fidelity of chromosome segregation in mitosis and meiosis. In response to defects in the mitotic apparatus, it blocks the activity of the anaphase-promoting complex, a large ubiquitin ligase required for chromosome segregation.
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Budding Yeast Cdc20: A Target of the Spindle Checkpoint
Science, 1998The spindle checkpoint regulates the cell division cycle by keeping cells with defective spindles from leaving mitosis. In the two-hybrid system, three proteins that are components of the checkpoint, Mad1, Mad2, and Mad3, were shown to interact with Cdc20, a protein required for exit from mitosis.
L H, Hwang +7 more
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Phosphorylation of Cdc20 is required for its inhibition by the spindle checkpoint
Nature Cell Biology, 2003The spindle checkpoint delays anaphase until all chromosomes are properly attached to spindle microtubules. When the spindle checkpoint is activated at unattached kinetochores, the checkpoint proteins BubR1, Bub3 and Mad2 bind and inhibit Cdc20, an activator of the anaphase-promoting complex (APC).
Eunah, Chung, Rey-Huei, Chen
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Bub1 and the multilayered inhibition of Cdc20–APC/C in mitosis
Trends in Cell Biology, 2005To ensure the accuracy of chromosome segregation in mitosis, the spindle checkpoint blocks the activity of the anaphase-promoting complex APC/C until all chromosomes are properly bi-orientated on the metaphase spindle. How the checkpoint machinery actually inhibits the APC/C is still unclear.
Vanoosthuyse, V., Hardwick, Kevin
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Phosphorylation of the Cyclosome Is Required for Its Stimulation by Fizzy/cdc20
Biochemical and Biophysical Research Communications, 1999Exit from mitosis in eukaryotic cells is regulated by the cyclosome (also called anaphase promoting complex or APC), a multisubunit ubiquitin ligase that acts on mitotic cyclins. Previous studies in a cell-free system from clam oocytes have shown that the activation of the cyclosome at the end of mitosis involves its phosphorylation by protein kinase ...
M, Shteinberg +4 more
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Cdc20 mediates D-box-dependent degradation of Sp100
Biochemical and Biophysical Research Communications, 2011Cdc20 is a co-activator of the anaphase-promoting complex/cyclosome (APC/C complex), which recruits substrates at particular phases of the cell cycle and mediates their degradation. Sp100 is a PML-NB scaffold protein, which localizes to nuclear particles during interphase and disperses from them during mitosis, participates in viral resistance ...
Ran, Wang +5 more
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CDC20 promotes radioresistance of prostate cancer by activating Twist1 expression
Apoptosis, 2023Chuanlai Yang +9 more
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