Results 241 to 250 of about 531,349 (289)

THE CDC2 PROTEIN KINASE: INTERACTIONS WITH ITS REGULATORY SUBUNITS

Biology of the Cell, 1992
Marcole Maria‐Jésus, Brambilla Paolo, D. Giulio, D. Bernard   +3 more
semanticscholar   +3 more sources

A family of trypanosome cdc2-related protein kinases

Gene, 1995
The cyclin-dependent kinases, most notable of which is cdc2, are key regulators of the cell cycle, and are highly conserved in evolution. We have cloned and analysed three cdc2-related kinase-encoding genes (tbcrk1-3) from the protozoan parasite Trypanosoma brucei.
Gareth Smith, Jeremy C. Mottram
openaire   +3 more sources

Protein phosphorylation during meiotic maturation of Xenopus oocytes: cdc2 protein kinase targets.

International Journal of Developmental Biology, 1990
M-Phase specific protein kinase or cdc2 protein kinase is a component of MPF (M-Phase promoting factor). During meiotic maturation of Xenopus oocytes, cdc2 protein kinase is activated in correlation with MPF activity.
R. Bellé, P. Cormier, R. Poulhe, J. Morales, D. Huchon, O. Mulner-lorillon   +5 more
semanticscholar   +1 more source

Activation of the various cyclin/cdc2 protein kinases

Current Opinion in Cell Biology, 1993
Recent research has led to the near culmination of the biochemical confirmation of the most basic genetic predictions about how p34cdc2 activity is controlled. The field is now moving from a biochemical dissection of the machinery to understanding how the system is regulated.
openaire   +3 more sources

Ras target protein canoe is a substrate for Cdc2 and Cdk5 kinases

Archives of Insect Biochemistry and Physiology, 2002
AbstractMutations in the canoe locus of Drosophila lead to failure in the dorsal closure of the embryonic epidermis and pattern formation defects in imaginal eyes and wings. In the wing, the canoe mutants develop extra veins when they are heterozygous for shaggy, a mutation in the locus encoding the glycogen synthase kinase 3β (Gsk3β), which has been ...
Noriko Hamada, Daisuke Yamamoto, Kuniaki Takahashi   +2 more
openaire   +3 more sources

Downregulation of the cdc2/Cyclin B Protein Kinase Activity by Binding of p53 to p34cdc2

Biochemical and Biophysical Research Communications, 2001
We previously found that p53 binds to the catalytic subunit of the p34(cdc2)/cyclin B1-kinase. In the present study we analyzed the functional consequences of this interaction. Binding of wild-type p53 to p34(cdc2)/cyclin B1 results in a significant decrease of its histone H1 kinase activity.
Claudia Götz, Muhannad Ababneh, Mathias Montenarh   +2 more
openaire   +3 more sources

Structure, function, and regulation of neuronal Cdc2-like protein kinase

Neurobiology of Aging, 1995
We have identified and purified from bovine brain a novel protein kinase which catalyzes in vitro phosphorylation of neurofilament proteins NF-H and NF-M and tau proteins at sites implicating the enzyme in the regulation of neurocytoskeleton dynamics and in Alzheimer pathology.
Lew, J., Qi, Robert Zhong, Huang, Q.Q., Paudel, H.K., Matsuura, I., Matsushita, M., Zhu, X., Wang, J.H.   +7 more
openaire   +5 more sources

The cdc2 kinase is a nuclear protein that is essential for mitosis in mammalian cells

Cell, 1989
A homolog of the fission yeast cdc2-encoded protein kinase (p34) is a component of M phase promoting factor in Xenopus oocytes. The homologous kinase in human HeLa cells is maximally active during mitosis, suggesting a mitotic role in mammalian somatic cells.
David Beach, Karl Riabowol, Giulio Draetta, Dale D. Vandre, Leonardo Brizuela   +4 more
openaire   +3 more sources

Identification of a Novel Drosophila Gene Encoding a Cdc2-Related Protein Kinase

The Journal of Biochemistry, 1994
We have identified a novel gene encoding a putative protein kinase from a Drosophila genomic library. The gene, about 2 kbp in length, consists of four exons and codes for a protein of 349 amino acid residues. The deduced sequence shows significant similarity to various kinases, especially to a subgroup of Ser/Thr kinases related to Cdc2 kinase; thus ...
Kaoru Saigo, Satoshi Ishimaru, Reiko Sugaya, Yasufumi Emori   +3 more
openaire   +3 more sources

PISSLRE, a human novel CDC2-related protein kinase.

Oncogene, 1994
The cell division cycle have been shown to be regulated by a closely-related family of protein kinases named CDKs (by cyclin-dependent kinases). Using a PCR-based cloning technique, we have isolated cDNAs encoding a human CDC2-related protein kinase. The full-length cDNA accommodates an open reading frame that does not contain any ATG initiation codon ...
GRANA X, CLAUDIO PP, DE LUCA, Antonio, SANG N, GIORDANO A.   +4 more
openaire   +3 more sources