Results 11 to 20 of about 37,980 (212)
A Role for Cdc42 in Macrophage Chemotaxis [PDF]
The Journal of Cell Biology, 1998 Three members of the Rho family, Cdc42, Rac, and Rho are known to regulate the organization of actin-based cytoskeletal structures. In Bac1.2F5 macrophages, we have shown that Rho regulates cell contraction, whereas Rac and Cdc42 regulate the formation of lamellipodia and filopodia, respectively.
Allen, William +3 more
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Cdc42 and Vesicle Trafficking in Polarized Cells [PDF]
Traffic, 2010 Cdc42, a highly conserved small GTPase of the Rho family, acts as a molecular switch to modulate a wide range of signaling pathways. Vesicle trafficking and cell polarity are two processes Cdc42 is known to regulate. Although the trafficking and polarity machineries are each well understood, how they interact to cross-regulate each other in cell ...
Kathryn P, Harris, Ulrich, Tepass
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miRNA-145/miRNA-205 inhibits proliferation and invasion of uveal melanoma cells by targeting NPR1/CDC42 [PDF]
International Journal of Ophthalmology, 2020 AIM: To investigate the role of microRNA-145 (miRNA-145) and microRNA-205 (miRNA-205) in proliferation and invasion of uveal melanoma (UM) cells. METHODS: The expression level of miRNA-145 and miRNA-205 from samples of UM patients were determined by ...
Yang Li +3 more
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Mate and fuse: how yeast cells do it [PDF]
Open Biology, 2013 Many cells are able to orient themselves in a non-uniform environment by responding to localized cues. This leads to a polarized cellular response, where the cell can either grow or move towards the cue source.
Laura Merlini +2 more
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Cells, 2020 Rho GTPases, including Rho, Cdc42, Rac and ROP subfamilies, are key signaling molecules in RNA polymerase II (Pol II) transcriptional control.
Bo Zhang +4 more
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Zhongguo shuxue zazhi, 2023 Objective To explore critical regulatory genes in the hemoglobin switch process by analyzing transcriptomic data from the GSE6236, GSE17639 and GSE35102 datasets.
Jinchao WANG, Genhao ZHANG
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Targeting Cdc42 in cancer [PDF]
Expert Opinion on Therapeutic Targets, 2013 The Rho GTPases are a family of proteins that control fundamental cellular processes in response to extracellular stimuli and internal programs. Rho GTPases function as molecular switches in which the GTP-bound proteins are active and GDP-bound proteins are inactive.
Luis E, Arias-Romero, Jonathan, Chernoff
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Cdc42 controls secretory granules morphology in rodent salivary glands in vivo
Communicative & Integrative Biology, 2020 We previously reported that the small GTPase Cdc42 negatively regulates endocytosis in the salivary gland of live mice. By using intravital subcellular microscopy, we showed that depletion of Cdc42 causes the mis-sorting of plasma membrane components ...
Akiko Shitara +2 more
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Gene targeting implicates Cdc42 GTPase in GPVI and non-GPVI mediated platelet filopodia formation, secretion and aggregation. [PDF]
PLoS ONE, 2011 Cdc42 and Rac1, members of the Rho family of small GTPases, play critical roles in actin cytoskeleton regulation. We have shown previously that Rac1 is involved in regulation of platelet secretion and aggregation.
Huzoor Akbar +7 more
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Regulation of cell protrusions by small GTPases during fusion of the neural folds
eLife, 2016 Epithelial fusion is a crucial process in embryonic development, and its failure underlies several clinically important birth defects. For example, failure of neural fold fusion during neurulation leads to open neural tube defects including spina bifida.
Ana Rolo +8 more
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