Results 11 to 20 of about 38,210 (217)
Regulation of cell protrusions by small GTPases during fusion of the neural folds
eLife, 2016 Epithelial fusion is a crucial process in embryonic development, and its failure underlies several clinically important birth defects. For example, failure of neural fold fusion during neurulation leads to open neural tube defects including spina bifida.
Ana Rolo +8 more
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Cdc42 Promotes Axonogenesis of Primary Hippocampal Neurons by Inhibiting Glycogen Synthase Kinase-3β
Journal of Integrative Neuroscience, 2022 Background: Progressive axon degeneration is a common pathological feature of neurodegenerative diseases. Cdc42 is a member of the Rho GTPase family that participates in axonogenesis.
Yu-Ting Li +10 more
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Lipidation of small GTPase Cdc42 as regulator of its physiological and pathophysiological functions
Frontiers in Physiology, 2023 The protein cell division cycle 42 (Cdc42) is a small GTPase of the Rho family regulating a plethora of physiological functions in a tissue, cell and subcellular-specific manner via participating in multiple signaling pathways.
Alexander Wirth, Evgeni Ponimaskin
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Science Signaling, 2012 Oscillations in the localization of active Cdc42 govern polarized cell growth in yeasts.
Bendezú FO, Martin SG
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Molecular subversion of Cdc42 signalling in cancer [PDF]
Biochemical Society Transactions, 2021 Cdc42 is a member of the Rho family of small GTPases and a master regulator of the actin cytoskeleton, controlling cell motility, polarity and cell cycle progression. This small G protein and its regulators have been the subject of many years of fruitful investigation and the advent of functional genomics and proteomics has opened up new avenues of ...
Murphy, Natasha P +3 more
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Cells, 2020 The small GTPase Cdc42 is critical for cell polarization in eukaryotic cells. In rod-shaped fission yeast Schizosaccharomyces pombe cells, active GTP-bound Cdc42 promotes polarized growth at cell poles, while inactive Cdc42-GDP localizes ubiquitously ...
Iker Lamas +2 more
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Mitosis can drive cell cannibalism through entosis
eLife, 2017 Entosis is a form of epithelial cell cannibalism that is prevalent in human cancer, typically triggered by loss of matrix adhesion. Here, we report an alternative mechanism for entosis in human epithelial cells, driven by mitosis.
Joanne Durgan +7 more
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GTPase-Activating Proteins for Cdc42 [PDF]
Eukaryotic Cell, 2002 ABSTRACT The Rho-type GTPase, Cdc42, has been implicated in a variety of functions in the yeast life cycle, including septin organization for cytokinesis, pheromone response, and haploid invasive growth. A group of proteins called GTPase-activating proteins (GAPs) catalyze the hydrolysis of GTP to GDP, thereby inactivating Cdc42.
Gregory R, Smith +3 more
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Mechanisms involved in the regulation of neuropeptide-mediated neurite outgrowth: a minireview
Endocrine Regulations, 2016 The present knowledge, regarding the neuronal growth and neurite extension, includes neuropeptide action in the central nervous system. Research reports have brought much information about the multiple intracellular signaling pathways of neuropeptides ...
Lestanova Z., Bacova Z., Bakos Jan
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Frontiers in Microbiology, 2021 Hepatitis E Virus (HEV) causes viral hepatitis in humans worldwide, while a subset of HEV species, avian HEV, causes hepatitis-splenomegaly syndrome in chickens.
Mengnan Fan +10 more
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