Results 291 to 300 of about 138,770 (367)

Novel Cereblon‐Binding Immunomodulators Have Increased Potency Against Gammaherpesvirus‐ Associated Lymphomas In Vitro

Journal of Medical Virology, Volume 97, Issue 8, August 2025.
ABSTRACT Primary effusion lymphoma (PEL), which is caused by Kaposi sarcoma herpesvirus (KSHV), and Burkitt lymphoma (BL), a subset of which are associated with Epstein‐Barr virus (EBV), are aggressive non‐Hodgkin's lymphomas. Both have relatively poor survival compared to other lymphomas. Cereblon‐binding immunomodulators (CBIs), such as pomalidomide (
Prabha Shrestha, Emma N. Treco, David A. Davis, Robert Yarchoan   +3 more
wiley   +1 more source

Risk Factors Associated with Suboptimal Real-World Outcomes in Patients with EGFR-Mutated Non-Small Cell Lung Cancer Treated with Front-Line Recommended Therapy. [PDF]

Adv Ther
Spira AI, Ran T, Lin I, Chen C, He A, Belani N, Du S.   +6 more
europepmc   +1 more source

The Antiviral Activity of Polyphenols

Molecular Nutrition &Food Research, Volume 69, Issue 15, August 2025.
Polyphenols demonstrate remarkable antiviral properties by effectively disrupting multiple biochemical processes essential for viral replication. ABSTRACT Polyphenols are secondary metabolites produced by a large variety of plants. These compounds that comprise the class of phenolic acids, stilbenes, lignans, coumarins, flavonoids, and tannins have a ...
Markus Burkard, Alban Piotrowsky, Christian Leischner, Katja Detert, Sascha Venturelli, Luigi Marongiu   +5 more
wiley   +1 more source

CDK inhibitors promote neuroblastoma cell differentiation and increase sensitivity to retinoic acid-a promising combination strategy for therapeutic intervention. [PDF]

Cell Death Discov
Shokraie F, Lechermeier L, Bordihn P, Kaps P, Möller S, Schulz AS, Schneider B, Koczan D, Roshan SK, Lode HN, Classen CF, Hahn O, Troschke-Meurer S, Maletzki C.   +13 more
europepmc   +1 more source

Mucinous cystic neoplasms and simple mucinous cysts are two distinct precursors of pancreatic cancer: clinicopathological, genomic, and transcriptomic characterization

The Journal of Pathology, Volume 266, Issue 4-5, Page 421-434, August 2025.
Abstract Mucinous cystic neoplasms (MCNs) of the pancreas are macroscopic precursors of pancreatic cancer. A similar cystic lesion but lacking the ovarian‐type subepithelial stroma has been recently defined as a simple mucinous cyst (SMC); however, its nature remains unclear. This study aims to define the clinicopathological and molecular profiles of a
Antonio Pea, Michele Bevere, Anastasios Gkountakos, Davide Pasini, Denise Fiorini, Andrea Mafficini, Stela Golovco, Michele Simbolo, Serena Pedron, Concetta Sciammarella, Paola Mattiolo, Aldo Mombello, Manuela Villanova, Carlotta Franzina, Francesca Masetto, Calogero Ciulla, Nicola Sperandio, Kohei Fujikura, Masha S. Ahadi, Jaswinder S. Samra, Amber L. Johns, Joanne Verheij, Martijn W.J. Stommel, Hjalmar van Santvoort, Leonor Schubert Santana, Giuseppe Malleo, Michele Milella, Lodewijk A. A. Brosens, Laura D. Wood, David K. Chang, Riccardo De Robertis, Mirko D'Onofrio, Anthony J. Gill, Roberto Salvia, Vincenzo Corbo, Rita T. Lawlor, Aldo Scarpa, Claudio Luchini   +37 more
wiley   +1 more source

Design, Synthesis, and Cytotoxicity Evaluation of Novel Indolin-2-One Based Molecules on Hepatocellular Carcinoma HepG2 Cells as Protein Kinase Inhibitors. [PDF]

Molecules
Kandeel MM, AbdElhameid MK, Adel M, Al-Shorbagy MY, Negmeldin AT.   +4 more
europepmc   +1 more source

Multi‐Target Drug Design in Alzheimer's Disease Treatment: Emerging Technologies, Advantages, Challenges, and Limitations

Pharmacology Research &Perspectives, Volume 13, Issue 4, August 2025.
ABSTRACT Alzheimer's disease (AD) is a complex and multifactorial neurodegenerative disorder, recognized as the most prevalent form of dementia. It is characterized by multiple pathological processes, including amyloid‐beta accumulation, neurofibrillary tangles, and neuroinflammation. The therapeutic efficacy of traditional single‐target drugs has been
Md Saad Hossain, Md Hamed Hussain
wiley   +1 more source

One‐at‐a‐Time Parameter Perturbation Ensemble of the Community Land Model, Version 5.1

Journal of Advances in Modeling Earth Systems, Volume 17, Issue 8, August 2025.
Abstract Comprehensive land models are subject to significant parametric uncertainty, which can be hard to quantify due to the large number of parameters and high model computational costs. We constructed a large parameter perturbation ensemble (PPE) for the Community Land Model version 5.1 with biogeochemistry configuration (CLM5.1‐BGC).
D. Kennedy, K. Dagon, D. M. Lawrence, R. A. Fisher, B. M. Sanderson, N. Collier, F. M. Hoffman, C. D. Koven, E. Kluzek, S. Levis, X. Lu, K. W. Oleson, C. M. Zarakas, Y. Cheng, A. C. Foster, M. D. Fowler, L. R. Hawkins, T. Kavoo, S. Kumar, A. J. Newman, P. J. Lawrence, F. Li, D. L. Lombardozzi, Y. Luo, J. K. Shuman, A. L. S. Swann, S. C. Swenson, G. Tang, W. R. Wieder, A. W. Wood   +29 more
wiley   +1 more source

Continuing Cyclin-Dependent Kinase 4/6 Inhibitors Beyond Progression in Advanced Breast Cancer: A Meta-Analysis. [PDF]

Cancers (Basel)
Pathak N, Kumar S, Gimenez DM, Di Iorio M, Savill J, Berner-Wygoda Y, Li M, Valiente CM, Cuthbert D, Gupta A, Arteaga DP, Batra A, Amir E, Mittal A.   +13 more
europepmc   +1 more source