Results 321 to 330 of about 138,770 (367)

Recent advances in AI-based toxicity prediction for drug discovery. [PDF]

Front Chem
Lee H, Kim J, Kim JW, Lee Y.
europepmc   +1 more source

MS275 Inhibits Neuroblastoma Cell Growth by Mediating H3K27ac/PROX1 Axis In Silico and In Vitro

The FASEB Journal, Volume 39, Issue 13, 15 July 2025.
Our study demonstrates that MS275, a selective HDAC inhibitor, suppresses HDAC1/3 protein expression, leading to hyperacetylation of histone H3 at lysine 27 (H3K27ac) within the PROX1 promoter region (−608 to −508). This epigenetic modification upregulates PROX1 transcription, which subsequently modulates key cellular processes, including cell cycle ...
Chao Yuan, Chaoqun Li, Junwei Lu, Shengjie Liao, Runkun Wu, Duanzhuo Li, Mi Huang, Dacong Gong, Weibin Wu, Xin Yu, Shinuan Fei, Wenxia Si   +11 more
wiley   +1 more source

The Cyclin-Dependent Kinase activity modulates the central carbon metabolism in maize during germination. [PDF]

Physiol Plant
Lara-Núñez A, Garza-Aguilar SM, Páez-Franco JC, de Dios Galindo-de-la-Rosa J, Vallejo-Becerra V.   +4 more
europepmc   +1 more source

Drug repurposing targeting COVID-19 3CL protease using molecular docking and machine learning regression approaches. [PDF]

Sci Rep
Aqeel I, Majid A, Albanyan A, Wasfi H.
europepmc   +1 more source

Phosphatase specificity influences phosphorylation timing of CDK substrates during the cell cycle

Zeisner TU, Auchynnikava T, Nurse P.
europepmc   +1 more source

E2F activity determines mitosis versus whole-genome duplication in G2-arrested cells. [PDF]

Nat Commun
Kim K, Armand J, Kim S, Yang HW.
europepmc   +1 more source

DTIAM: a unified framework for predicting drug-target interactions, binding affinities and drug mechanisms. [PDF]

Nat Commun
Lu Z, Song G, Zhu H, Lei C, Sun X, Wang K, Qin L, Chen Y, Tang J, Li M.   +9 more
europepmc   +1 more source

The Impact of Progesterone Receptor Status on Survival Outcomes in Metastatic Breast Cancer Patients Treated with First-Line CDK4/6 Inhibitors. [PDF]

Cancers (Basel)
Guliyev M, Güren AK, Özge E, Çolak R, Majidova N, Alkan Şen G, Safarov S, Günaltılı M, Fidan MC, Gültürk İ, Yılmaz M, Bayoğlu İV, Demirci NS, Alan Ö.   +13 more
europepmc   +1 more source

Combined therapy with DR5-targeting antibody-drug conjugate and CDK inhibitors as a strategy for advanced colorectal cancer. [PDF]

Cell Rep Med
Zhou D, Tang E, Wang W, Xiao Y, Huang J, Liu J, Zheng C, Zhang K, Hu R, Wang F, Xiong P, Chu X, Li W, Liu D, Zeng X, Zheng D, Wang L, Zheng Y, Zhang S.   +18 more
europepmc   +1 more source

Genotypes in the 17q12‐q21 asthma risk locus and early‐life viral wheezing illnesses

Pediatric Allergy and Immunology, Volume 36, Issue 8, August 2025.
Nathan Schoettler, Tebeb Gebretsadik, Sweta Singh, Lisa Gress, Eneida A. Mendonça, Brittney M. Snyder, Amy A. Eapen, Petra LeBeau, Ronald Gangnon, Christine M. Seroogy, Leonard B. Bacharier, Robert F. Lemanske Jr, Susan V. Lynch, Diane R. Gold, Rachel L. Miller, Daniel J. Jackson, Gurjit K. Khurana Hershey, Christine C. Johnson, Fernando D. Martinez, Carole Ober, Tina V. Hartert, James E. Gern, for the ECHO Children's Respiratory and Environmental Workgroup, Kathrine L. Barnes, Pam Bates, Jessica Baucom, Patrice Becker, Casper G. Bendixsen, Alex Binder, Nikki Bires, Rashida Blackwood, Yury A. Bochkov, Steven M. Brunwasser, Richard Budrevich, Emily Bull, Thomas Callaci, Kirsten Carlson‐Dakes, Tara F. Carr, Jacqueline Cephus, James D. Chappell, Jack Charles, Deborah Chasman, Teresa M. Chipps, Tatiana Chirkova, Kamry Coffey, Gina Crisafi, Suman R. Das, Douglas DaSilva, Lydia De La Ossa, Stephanie Doss, Amy Dresen, William D. Dupont, Abby Engelhart, Heather Floerke, Wais Folad, Terry Foss, Angela Freie, Wayne Frome, Samantha Fye, Lisa Gagalis, Peter Gergen, Nicole Gonzalez, Kayla Goodman, Kristine Grindle, Brian Hallmark, Marilyn Halonen, Erin Higdon, Samadhan J. Jadhao, Molly Johnson, Tara Johnson, Meyer Kattan, Rick Kelley, Tammy Koepel, Cole Lacey, Laura Ladick, Carin Lamm, Kristine Lee, Stephanie Leimenstoll, Zhouwen Liu, Silvia Lopez, Stephanie Lovinsky‐Desir, Ana Manuelian, Jennifer Markevich, Lisa Martin, Jomol Matthew, Christopher G. McKennan, Jennifer Meece, Lance Mikus, Vicki Moon, Wayne J. Morgan, George T. O’Connor, Brent F. Olson, Irene Ong, Tressa Pappas, Barron Patterson, Brenda Patterson, R. Stokes Peebles, Marcela Pierce, DeeAnn Polacek, Kadijah Poleon, Victoria Rajamanickam, Kimberly Ray, Sara Reiss, Chris M Reyes, Kathleen Roberg, Christian Rosas‐Salazar, Pat Russell, Lisa Salazar, Hugh Sampson, Megan T. Sandel, Ruchika Sangani, Dena Scott, Meghan H. Shilts, Akihiro Shiroshita, Gina Simpson, Zhengzheng Tang, Christopher Tisler, Alkis Togias, Jeffrey J. VanWormer, Renee Welch, Robert A. Wood, Anne L. Wright, Rosalind J. Wright, Melissa Yaeger, Perri Yaniv   +124 more
wiley   +1 more source