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Characterization of a novel cdk1‐related kinase
European Journal of Biochemistry, 1999The p13suc1/p9CKShs proteins bind tightly to the cyclin‐dependent kinases cdk1 and cdk2. The distantly related protein, p15cdk‐BP, binds cdk4/6, cdk5 and cdk8. We now show that immobilized p15cdk‐BP binds both an HMG‐I kinase and a 35‐kDa protein that cross‐reacts with anti‐PSTAIRE antibodies (PSTAIRE is a totally conserved motif located in subdomain ...
L, Détivaud, G R, Pettit, L, Meijer
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Cdk1: the dominant sibling of Cdk2
Nature Cell Biology, 2005Cdk2 is thought to regulate entry into S phase, whereas Cdk1 controls the initiation of mitosis. New evidence shows that Cdk1 is equally capable of promoting the G1/S transition in Cdk2−/− cells, raising the question as to whether Cdk1 constitutes the predominant cyclin-dependent kinase in mammalian cells, or only compensates for Cdk2 function when it ...
Tarig Bashir, Michele Pagano
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[CDK1 expression and effects of CDK1 silencing on the malignant phenotype of glioma cells].
Zhonghua zhong liu za zhi [Chinese journal of oncology], 2010Our previous cDNA array data have shown that expression level of CDK1 increased along with the malignant progression of ganglioglioma, and decreased with the differentiation process of neural stem cells. The purpose of this study was to investigate the CDK1 expression levels in gliomas and the effects of CDK1 knockdown on phenotype of glioma cells ...
Hua, Chen +5 more
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Homology Model of the CDK1/cyclin B Complex
Journal of Biomolecular Structure and Dynamics, 2005We describe a refined homology model of a CDK1/cyclin B complex that was previously used for the structure-based optimization of the Paullone class of inhibitors. The preliminary model was formed from the homologous regions of the deposited CDK2/cyclin A crystal structure. Further refinement of the CDK1/cyclin B complex was accomplished using molecular
Connor F, McGrath +7 more
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CDK1 promotes the stemness of lung cancer cells through interacting with Sox2
Clinical and Translational Oncology, 2021Z. Huang, G. Shen, J. Gao
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MiR-495-3p and miR-143-3p co-target CDK1 to inhibit the development of cervical cancer
Clinical and Translational Oncology, 2021J. Tang +6 more
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