Results 311 to 320 of about 69,037 (327)
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Correlation between CDK1 protein and CDK1 mRNA during oocyte maturation in mouse
The International Journal of Developmental Biology, 2022The aim of this study was to investigate the correlation between CDK1 protein and CDK1 mRNA during oocyte maturation in vivo in mouse. GV, GVBD, MI and MII oocytes were obtained from mice, respectively. Western blot validated that the CDK1 protein expression increased continuously and significantly with oocyte maturation in vivo (P<0.05).
Ya-Ting, Sun, Ai-Zhen, Zhu
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Cdk1: the dominant sibling of Cdk2
Nature Cell Biology, 2005Cdk2 is thought to regulate entry into S phase, whereas Cdk1 controls the initiation of mitosis. New evidence shows that Cdk1 is equally capable of promoting the G1/S transition in Cdk2−/− cells, raising the question as to whether Cdk1 constitutes the predominant cyclin-dependent kinase in mammalian cells, or only compensates for Cdk2 function when it ...
Tarig Bashir, Michele Pagano
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Targets of the cyclin-dependent kinase Cdk1
Nature, 2003The events of cell reproduction are governed by oscillations in the activities of cyclin-dependent kinases (Cdks). Cdks control the cell cycle by catalysing the transfer of phosphate from ATP to specific protein substrates. Despite their importance in cell-cycle control, few Cdk substrates have been identified.
Jeffrey A. Ubersax +12 more
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Cohesin and Cdk1: an anaphase barricade
Nature Cell Biology, 2010Separation of sister chromatids at anaphase in metazoan cells requires only the cleavage of the kleisin subunit of centromeric cohesin, but efficient poleward movement of separated sisters requires the associated loss in Cdk1 activity. Activation of the anaphase-promoting complex/cyclosome ensures these events are coordinated.
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Homology Model of the CDK1/cyclin B Complex [PDF]
Journal of Biomolecular Structure and Dynamics, 2005 We describe a refined homology model of a CDK1/cyclin B complex that was previously used for the structure-based optimization of the Paullone class of inhibitors. The preliminary model was formed from the homologous regions of the deposited CDK2/cyclin A crystal structure. Further refinement of the CDK1/cyclin B complex was accomplished using molecular
Nagarajan Pattabiraman +7 more
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Cdk1 and cell morphology: connections and directions
Current Opinion in Cell Biology, 2009Cells undergo dramatic shape transitions as they progress through the cell cycle. Here, we discuss how communication between the ubiquitous cell cycle regulator Cdk1 and cell morphology factors such as Cdc42 coordinates the cell cycle and cell morphology in the budding and fission yeasts.
James B. Moseley, Paul Nurse
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Cep63 Recruits Cdk1 to the Centrosome—Letter
Cancer Research, 2015In 2011, we published a characterization of the phenotypes of Cep63 downregulation and overexpression in human cells in Cancer Research ([1][1]). Recently, it was shown that several antibodies commonly used to detect Cdk1 cross-react with Cep152 ([2][2]).
Jiri Bartek +4 more
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Characterization of a novel cdk1‐related kinase
European Journal of Biochemistry, 1999The p13suc1/p9CKShs proteins bind tightly to the cyclin‐dependent kinases cdk1 and cdk2. The distantly related protein, p15cdk‐BP, binds cdk4/6, cdk5 and cdk8. We now show that immobilized p15cdk‐BP binds both an HMG‐I kinase and a 35‐kDa protein that cross‐reacts with anti‐PSTAIRE antibodies (PSTAIRE is a totally conserved motif located in subdomain ...
George R. Pettit +2 more
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CDK1/2/5 inhibition overcomes IFNG-mediated adaptive immune resistance in pancreatic cancer
Gut, 2020Objective Adaptive immune resistance mediated by the cytokine interferon gamma (IFNG) still constitutes a major problem in cancer immunotherapy.
Jin Huang +13 more
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CDK1 in Breast Cancer: Implications for Theranostic Potential.
Anti-Cancer Agents in Medicinal Chemistry, 2020Breast cancer has been identified as one of the main cancer-related deaths among women during some last decades. Recent advances in the introduction of novel potent anti-cancer therapeutics in association with early detection methods led to a decrease in
Sepideh Izadi +7 more
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