Results 111 to 120 of about 149,367 (278)

Integrative Modeling in the Age of Machine Learning: A Summary of HADDOCK Strategies in CAPRI Rounds 47–55

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The HADDOCK team participated in CAPRI rounds 47–55 as server, manual predictor, and scorers. Throughout these CAPRI rounds, we used a plethora of computational strategies to predict the structure of protein complexes. Of the 10 targets comprising 24 interfaces, we achieved acceptable or better models for 3 targets in the human category and 1 ...
Victor Reys, Marco Giulini, Vlad Cojocaru, Anna Engel, Xiaotong Xu, Jorge Roel‐Touris, Cunliang Geng, Francesco Ambrosetti, Brian Jiménez‐García, Zuzana Jandova, Panagiotis I. Koukos, Charlotte van Noort, João M. C. Teixeira, Siri C. van Keulen, Manon Réau, Rodrigo V. Honorato, Alexandre M. J. J. Bonvin   +16 more
wiley   +1 more source

Performance of pyDock in 8th CAPRI: Energy‐Based Scoring Applied to Docking and AlphaFold Models

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The 8th CAPRI edition has shown a significant evolution in the field of protein–protein complex structure prediction. We have participated in all 11 targets proposed in this edition, involving domain‐domain, protein–protein, protein‐peptide, and protein‐DNA interactions, including homo‐ and hetero‐meric interfaces.
Luis Angel Rodríguez‐Lumbreras, Mireia Rosell, Miguel Romero‐Durana, Víctor Monteagudo, Fabian Glaser, Juan Fernandez‐Recio   +5 more
wiley   +1 more source

Embedded Interactions and Selective Disclosure: Network Effects on Conversations aboard Skylab

Symbolic Interaction, EarlyView.
How do absent others influence our interactions? We argue in this paper that interactions are embedded within networks formed by chains of specific relationships between known third parties. The anticipation of future interactions with external others conditions our interpretation of the current situation and affects our behavior in the interaction. We
Michael Schultz, Leslie DeChurch, Noshir Contractor   +2 more
wiley   +1 more source

Innovation in the Agro-Food Sector: From technical Innovation-centred Approaches to Sustainability transition Processes [PDF]

International Journal of Agricultural Management and Development, 2018
Innovation is a complex phenomenon and process involving translation of knowledge into new techniques, products, services. It is considered crucial for sustainable agriculture development and achievement of long-term food security.
Hamid El Bilali
doaj  

Carya nux‐taurinensis comb. nov., a fossil‐species incorporating Carya globosa (Juglandaceae)

TAXON, EarlyView.
Abstract The type material of the almost forgotten fossil‐species Juglans nux‐taurinensis is newly analysed, a lectotype is designated, and new conspecific material detected at the Italian type locality La Morra is described. We show that Juglans nux‐taurinensis must be reassigned to Carya because the locule cast of the nutshell shows two inner ...
Edoardo Martinetto, Dario De Franceschi, Cedric Del Rio, Steven R. Manchester   +3 more
wiley   +1 more source

Evaluación imagenológica del compromiso óseo en la enfermedad de Gaucher

Revista Paraguaya de Reumatología, 2016
La Enfermedad de Gaucher (EG ) es la enfermedad de depósito lisosomal más frecuente. La deficiente actividad de la enzima Hidrolasa-β-glucosidasa lleva a la acumulación de glucocerebrósidos principalmente en médula ósea, bazo, hígado y pulmones causando ...
Gabriel Aguilar
doaj  

Cash‐holding Benefits and Their Influence on Seasoned Equity Offering Decisions

Abacus, EarlyView.
This study investigates the cash‐holding motivations of issuers with excess cash. It aims to explain why these issuers choose to accumulate even more cash through stock issuances rather than utilize their existing surplus. I assess three competing cash‐holding motivation hypotheses: whether issuers raise cash: (i) to fund the needs of future growth ...
Ebrahim Bazrafshan
wiley   +1 more source

Impact of National Screening Programs on Down syndrome prevalence and outcomes

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
Over the past two decades, pregnancies with DS, prenatal diagnosis, and subsequent terminations have increased. Yet, the proportion continuing pregnancy after diagnosis and the prevalence of live‐ and stillbirths with DS have remained stable throughout the same period.
Cecilie Bryn Nordklev, Denise Reis Costa, Roy Miodini Nilsen, Nils‐Halvdan Morken, Siri Vangen, Vasilis Sitras   +5 more
wiley   +1 more source

Tau‐targeting active immunotherapy slows progression and reduces pathology in mouse models of tauopathy

Brain Pathology, EarlyView.
The efficacy of the novel anti‐tau active immunotherapy, p5555kb, was tested using two mouse models of tau pathology. p5555kb inoculation increased the survival rate and reduced tau pathology in tau‐overexpressing P301L mice and decreased tau seeding in the brains of C57BL/6 mice injected with human‐purified Alzheimer's disease tau.
Christopher M. Brown, Jeanne K. Brooks, Louise Kelly, Madeline M. Vroom, Matthew Longo, Jean‐Cosme Dodart, Roxana Carare, Justin D. Boyd   +7 more
wiley   +1 more source

Distinct regional patterns of synaptic vulnerability across hippocampal and parahippocampal subregions in Alzheimer's disease

Brain Pathology, EarlyView.
Synaptic loss in Alzheimer's disease predominantly affects the entorhinal cortex and parahippocampal gyrus. Amyloid‐β and p‐tau pathology show global associations with synaptic density but are limited in specific subregions. Instead, axonal damage associates with synaptic loss locally and in interconnected subregions.
Maud M. A. Bouwman, Irene Frigerio, Yvon Galis‐de Graaf, Wilma D. J. van de Berg, Laura E. Jonkman   +4 more
wiley   +1 more source