Results 201 to 210 of about 149,367 (278)

Reduced triacylglycerols and lipid droplets are associated with resilience to Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Although it has become clear that alterations in lipid metabolism are associated with Alzheimer's disease (AD), it is unclear how they contribute to both cognitive decline and the pathophysiology of AD. METHODS Lipidomics and activity‐based protein profiling (ABPP) were performed in the frontal cortex of control, AD and resilient ...
Daan van der Vliet, Luuk E. de Vries, Xinyu Di, Dennis Wever, Brechtje de Jong, Marc T. C. van der Meij, Marielle van der Peet, Amy C. Harms, Thomas Hankemeier, Dick F. Swaab, Inge Huitinga, Joost Verhaagen, Mario van der Stelt   +12 more
wiley   +1 more source

Proteomics reveals three molecular subtypes of Alzheimer's disease with distinct progression patterns

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) shows marked molecular heterogeneity. Defining biological subtypes may refine diagnosis and treatment. METHODS We analyzed cerebrospinal fluid (CSF) proteomics and longitudinal data from 550 participants in the Alzheimer's Disease Neuroimaging Initiative with up to 16.5 years of follow‐up. We profiled 6361
Xiao‐He Hou, Wei Zhang, Kairan Kang, Yifei Jin, Peng Ren, Linbo Wang, Zeyu Li, Yuzhu Li, Jia You, Bei Zhang, Qing Ma, for the Alzheimer's Disease Neuroimaging Initiative, Fang Xie, Jin‐Tai Yu, Jian‐Feng Feng, Wei Cheng   +15 more
wiley   +1 more source

Validity of gold-standard clinical outcome assessments in U.S. Latinx-Hispanic participants enrolled in Alzheimer's disease clinical trials: A literature review. [PDF]

Alzheimers Dement
Monserratt LH, Morales JA, Mohammed A, Ovalle-Eliseo S, Islas-Huerta G, Perez LA, Díaz-Santos M.   +6 more
europepmc   +1 more source

Differential item functioning of the Geriatric Depression Scale‐short form in the NACC dataset

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION This study examined differential item functioning of the Geriatric Depression Scale – Short Form (GDS‐SF) in the National Alzheimer's Coordinating Center (NACC) Uniform Data Set (UDS) to identify potential variables that produce measurement bias. METHODS Data from 14077 individuals’ first NACC visit were analyzed.
Brenna N. Renn, Chad L. Cross, Ishrat Zaman, Katie T. Singsank, Kimberly Cobos, Samantha E. John   +5 more
wiley   +1 more source

From the Editor's desk

Indian Journal of Rheumatology, 2009
Wg Cdr S Shankar
doaj   +1 more source

Association between brain volume and depression in Alzheimer's disease: Neuroimaging insights

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) often co‐occurs with depression, affecting cognitive function and quality of life. Understanding the neurobiological links between brain abnormalities and depressive symptoms is essential for effective treatment.
Chao Tang, Jiaxin Yang, Xiaoyang Lei, Ming Zhang, Yi Chen, Xiaoxue Peng, Dian He   +6 more
wiley   +1 more source

D3.13Critical Design Review (CDR)

Critical Design Review (CDR)
openaire   +1 more source

Deep cervical lymphatic–venous anastomosis attenuates cognitive dysfunction and biomarker abnormalities in severe Alzheimer's disease: A prospective single‐arm study

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION This study evaluated the efficacy of deep cervical lymphatic–venous anastomosis (dcLVA) for severe Alzheimer's disease (AD). METHODS A total of 139 severe AD patients undergoing dcLVA were enrolled, and changes in cognitive function and biomarkers were evaluated by comparing preoperative measures with postoperative outcomes over a
Xiaohong Fu, Jing Zhang, Qiuxia Xiao, Tingting Li, Qijun Li, Shaofu Zhang, Wen Zeng, Min Gong, Pan Cai, Zhaojian Deng, Xuan Zhang, Yuanjun Xin, Liping Su, Xiaohe Tian, Kaifeng Wu, Liulin Xiong   +15 more
wiley   +1 more source

Therapeutic Drug Monitoring for Individualized Antidepressant Treatment. [PDF]

Drug Des Devel Ther
Li Y, Du X, An J, Wu H.
europepmc   +1 more source

Alzheimer's clinical research data via R packages: The alzverse

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Sharing clinical research data is essential for advancing Alzheimer's disease (AD) research, yet challenges in accessibility, standardization, documentation, usability, and reproducibility persist. METHODS We developed R data packages to streamline access to curated datasets from key AD studies. A4LEARN includes data from the Anti‐
Michael C. Donohue, Kedir Hussen, Oliver Langford, Richard Gallardo, Gustavo Jimenez‐Maggiora, Paul S. Aisen, for the Alzheimer's Disease Neuroimaging Initiative   +6 more
wiley   +1 more source