Results 201 to 210 of about 6,828 (261)
Abstract Since 2016, the Alzheimer's Association and the Fondation Alzheimer have hosted Global Alzheimer's Leadership Series (GoALS) global think tanks, with world‐leading experts for innovative discussions to advance Alzheimer's disease (AD) research and care.
Philippe Amouyel +26 more
wiley +1 more source
Abstract BACKGROUND Linkage to medical services enables timely diagnosis and treatment, yet racial/ethnic minority older adults with limited English proficiency (LEP) face substantial barriers. We tested Preparing Healthy Aging through Dementia Literacy Education and Navigation (PLAN), a language‐concordant community health worker (CHW)‐led ...
Hae‐Ra Han +8 more
wiley +1 more source
Prevalence of high‐risk plasma p‐tau217 levels and 5‐year transition of risk status in 70‐year‐olds
Abstract INTRODUCTION High‐risk plasma p‐tau217 levels predict amyloid‐β pathology in Alzheimer's disease, but little is known about the prevalence and temporal dynamics in the general population. METHODS Participants from the Gothenburg H70 Birth Cohort Study in Sweden were examined (n = 1157) and re‐examined after 5–7 years (n = 771).
Anna Dittrich +9 more
wiley +1 more source
Abstract INTRODUCTION Imaging‐based cerebral small vessel disease (CSVD) summary scores quantify CSVD burden. This study characterized CSVD scores and assessed their cognitive associations in older adults with various neurodegenerative diseases and cognitive profiles.
Dylan X. Guan +5 more
wiley +1 more source
Abstract INTRODUCTION Prior studies showed inconsistent links between dietary fat and Alzheimer's disease (AD) risk. We examined whether dietary fat affected brain atrophy markers differentially based on risk factors like female sex, apolipoprotein ε4 (APOE ε4) status, and cognitive status.
Lei Fan +9 more
wiley +1 more source
Abstract INTRODUCTION In Peru, the Global Deterioration Scale is the only available tool for assessing dementia severity. The Spanish translation and cultural adaptation of the Clinical Dementia Rating (CDR) is used locally but requires formal psychometric validation in the Peruvian sociocultural context.
Junior Senador +9 more
wiley +1 more source
Abstract INTRODUCTION Disturbed sleep and physical inactivity are associated with increased risk for dementia. However, associations with Alzheimer's disease (AD) pathology, and whether these associations differ depending on underlying disease risk, remain unclear. METHODS We examined associations of actigraphy‐derived total volume of physical activity
Daniel D. Callow +8 more
wiley +1 more source
Allele specific expression in Alzheimer's disease
Abstract INTRODUCTION Allele‐specific expression (ASE), preferential expression of one allele at a heterozygous locus, is implicated in various brain diseases but remains largely uncharacterized in Alzheimer's disease (AD). METHODS We performed a genome‐wide characterization of ASE variants across seven brain regions of 2,231 AD and Control patients ...
Zishan Wang +6 more
wiley +1 more source
Abstract INTRODUCTION It is desirable to measure brain metabolism without needing ionizing radiation and elucidate its time trajectory. This study employed a positron emission tomography ‐validated, non‐invasive magnetic resonance imaging (MRI) technique to characterize longitudinal changes in cerebral metabolic rate of oxygen (CMRO2) in both ...
Jiani Wu +14 more
wiley +1 more source

