Mapping Anatomical Boundaries from Histology to Antemortem MRI to Inform Automatic Segmentation of Medial Temporal Lobe Subregions [PDF]
Abstract Background The medial temporal lobe (MTL) is the epicenter of both primary and concomitant molecular pathologies in Alzheimer’s disease (AD). The intricate anatomy of the MTL has been the subject of extensive study over the past two centuries.
Amanda E Denning +31 more
wiley +4 more sources
Associations between Quantitative Neuronal Loss Measures and Postmortem MRI Atrophy Measures in the Human Medial Temporal Lobe in AD and LATE [PDF]
Abstract Background Medial temporal lobe (MTL) atrophy measured on MRI is a sensitive biomarker of AD‐linked neurodegeneration but is not specific to AD. LATE is a common AD co‐pathology that is challenging to distinguish from AD based on available validated biomarkers. LATE and AD are both associated with hippocampus and entorhinal cortex atrophy, but
Paul A. Yushkevich +31 more
wiley +2 more sources
Neuropeptides in the developing human hippocampus under hypoxic–ischemic conditions [PDF]
Hypoxia‐ischemia during the perinatal period could damage the hippocampal interneuron populations which might lead to the appearance of different problems during subsequent development. Interneurons containing Somatostatin and Neuropeptide Y located in the hippocampal ammonic fields are affected differently, although there is a global reduction after ...
Joaquín González Fuentes +6 more
wiley +2 more sources
Developing an Anatomically Valid Segmentation Protocol for Anterior Regions of the Medial Temporal Lobe for Neurodegenerative Diseases [PDF]
ABSTRACT The anterior portion of the medial temporal lobe (MTL) is one of the first regions targeted by pathology in sporadic Alzheimer's disease (AD) and limbic‐predominant age‐related TDP‐43 encephalopathy (LATE) indicating a potential for metrics from this region to serve as imaging biomarkers.
Niyousha Sadeghpour +32 more
wiley +2 more sources
Developing an anatomically valid segmentation protocol for anterior regions of the medial temporal lobe [PDF]
Abstract Background The anterior portion of the MTL is one of the first regions targeted by pathology in sporadic Alzheimer’s disease (AD) indicating the potential for imaging metrics from this region to serve as valuable imaging biomarkers. However, most existing automated approaches for MTL segmentation do not incorporate anterior MTL subregions, and
Niyousha Sadeghpour +30 more
wiley +2 more sources
Prophylactic Zinc Administration Combined with Swimming Exercise Prevents Cognitive‐Emotional Disturbances and Tissue Injury following a Transient Hypoxic‐Ischemic Insult in the Rat [PDF]
Exercise performance and zinc administration individually yield a protective effect on various neurodegenerative models, including ischemic brain injury. Therefore, this work was aimed at evaluating the combined effect of subacute prophylactic zinc administration and swimming exercise in a transient cerebral ischemia model.
Ana-Karina Aguilar-Peralta +14 more
wiley +2 more sources
La articulación jurídica de las relaciones entre la UE y el Mercosur [PDF]
El instrumento jurídico que marca al día de hoy las relaciones entre los dos bloques regionales es el Acuerdo Marco de cooperación celebrado entre la CE y sus Estados miembros, de una parte, y el Mercosur, con sus Estados partes, de otra l. Por tanto, la
Cebada Romero, Alicia
core +35 more sources
La transformación cebada -malta - cerveza constituye un capítulo tan importante como antiguo de la tecnología de los cereales. En los caracteres cuneiformes de la mesa de arcilla del Louvre, del siglo vil antes de Jesucristo, ya se encuentran datos sobre la cerveza y su elaboración por los sumerios.
García Olmedo, Francisco
openaire +4 more sources
Abstract Monitoring is critical to assess management effectiveness, but broadscale systematic assessments of monitoring to evaluate and improve recovery efforts are lacking. We compiled 1808 time series from 71 threatened and near‐threatened terrestrial and volant mammal species and subspecies in Australia (48% of all threatened mammal taxa) to compare
Ayesha I. T. Tulloch +14 more
wiley +1 more source
The Death Penalty and Historical Change in Spain
Abstract This article studies the long duration of the death penalty in Spain until its abolition in the Constitution of 1978. After analysing the plurality of theoretical approaches and possibilities offered by archival sources and specialised historiography (particularly those produced by specialists in the history of law and social history), I ...
Pedro Oliver Olmo
wiley +1 more source

