Results 41 to 50 of about 4,021 (204)

Tolerability and efficacy study of P2X7 inhibition in experimental Charcot-Marie-Tooth type 1A (CMT1A) neuropathy

open access: yesNeurobiology of Disease, 2016
Charcot-Marie-Tooth 1A (CMT1A) is a demyelinating hereditary neuropathy for which pharmacological treatments are not yet available. An abnormally high intracellular Ca2+ concentration was observed in Schwann cells (SC) from CMT1A rats, caused by the ...
Giovanna Sociali   +8 more
doaj   +1 more source

CebR as a Master Regulator for Cellulose/Cellooligosaccharide Catabolism Affects Morphological Development in Streptomyces griseus [PDF]

open access: yesJournal of Bacteriology, 2009
ABSTRACT Streptomyces griseus mutants exhibiting deficient glucose repression of β-galactosidase activity on lactose-containing minimal medium supplemented with a high concentration of glucose were isolated. One of these mutants had a 12-bp deletion in cebR , which encodes a LacI/GalR family ...
Kazuya, Marushima   +2 more
openaire   +2 more sources

Sphingomyelin as a myelin biomarker in CSF of acquired demyelinating neuropathies

open access: yesScientific Reports, 2017
Fast, accurate and reliable methods to quantify the amount of myelin still lack, both in humans and experimental models. The overall objective of the present study was to demonstrate that sphingomyelin (SM) in the cerebrospinal fluid (CSF) of patients ...
Giovanna Capodivento   +14 more
doaj   +1 more source

Fungi and Circular Economy: Pleurotus ostreatus Grown on a Substrate with Agricultural Waste of Lavender, and Its Promising Biochemical Profile

open access: yesRecycling, 2021
The increasing production of essential oils has generated a significant amount of vegetal waste that must be discarded, increasing costs for farmers. In this context, fungi, due to their ability to recycle lignocellulosic matter, may be used to turn this
Simone Di Piazza   +5 more
doaj   +1 more source

Beyond Values: Business Orientation as a Driver of Small Business Social Responsibility

open access: yesCorporate Social Responsibility and Environmental Management, Volume 32, Issue 5, Page 6879-6896, September 2025.
ABSTRACT Small businesses differ from larger corporations in their approach to corporate social responsibility (CSR) due to their unique reliance on the personal values of owner/managers. This study employs an abductive research methodology to explore the depth and relative influence of these personal values, in contrast to business motivations, on ...
Barbara Tomasella, Elaine Conway
wiley   +1 more source

Luminescence Efficiency and Spectral Compatibility of Cerium Fluoride (CeF3) Inorganic Scintillator with Various Optical Sensors in the Diagnostic Radiology X-ray Energy Range

open access: yesInorganics
The aim of this study was to experimentally assess the luminescence efficiency of a cerium fluoride (CeF3) inorganic scintillator in crystal form as a possible alternative to high-luminescence but hygroscopic cerium bromide (CeBr3).
Vasileios Ntoupis   +6 more
doaj   +1 more source

High-throughput screening for modulators of ACVR1 transcription: discovery of potential therapeutics for fibrodysplasia ossificans progressiva

open access: yesDisease Models & Mechanisms, 2016
The ACVR1 gene encodes a type I receptor of bone morphogenetic proteins (BMPs). Activating mutations in ACVR1 are responsible for fibrodysplasia ossificans progressiva (FOP), a rare disease characterized by congenital toe malformation and progressive ...
Serena Cappato   +11 more
doaj   +1 more source

Healthcare Worker Study Cohort to Determine the Level and Durability of Cellular and Humoral Immune Responses after Two Doses of SARS-CoV-2 Vaccination

open access: yesVaccines, 2022
We prospectively studied immunological response against SARS-CoV-2 after vaccination among healthcare workers without (group A) and with previous infection (group B).
Chiara Dentone   +21 more
doaj   +1 more source

Results from the experimental evaluation of CeBr scintillators for He prompt gamma spectroscopy [PDF]

open access: yesMedical Physics, 2019
PurposeThe presence of range uncertainties hinders the exploitation of the full potential of charged particle therapy. Several range verification techniques have been proposed to mitigate this limitation. Prompt gamma spectroscopy (PGS) is among the most promising solutions for online and in vivo range verification.
Riccardo Dal Bello   +5 more
openaire   +1 more source

Natural Killer Cell Development and Maturation Revisited: Possible Implications of a Novel Distinct Lin−CD34+DNAM-1brightCXCR4+ Cell Progenitor

open access: yesFrontiers in Immunology, 2017
Since the first description of natural killer (NK) cells, the view on their role in innate immunity has evolved considerably. In addition to first-line defense against transformed and pathogen-infected autologous cells, NK cells contribute to modulate ...
Federica Bozzano   +5 more
doaj   +1 more source

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