Results 261 to 270 of about 42,856 (342)

Activated Platelet–Released Heat Shock Protein 90α Triggers Autophagy‐Dependent Neutrophil Extracellular Trap Formation and Amplifies Sepsis

Advanced Science, Volume 13, Issue 25, 4 May 2026.
HSP90α is significantly upregulated in platelets from sepsis patients, with its origin from megakaryocyte‐derived trafficking. Furthermore, activated platelets secrete HSP90α into the extracellular space in both free and exosome‐associated forms. Finally, extracellular HSP90α directly engages TLR4 on neutrophils to induce autophagy, leading to NET ...
Chengbo Wang, Maodong Leng, Chenchen Sun, Jingyu Cao, Linfei Li, Yangyang Jia, Yongshuai Han, Yuchun Liu, Yaodong Zhang, Chenglong Zhang, Yingli Men, Ningyuan Liu, Yibing Cheng, Yixia Zhang, Ya Li, Zhenlong Li, Lidan Cui, Xiangzhan Zhu   +17 more
wiley   +1 more source

Navigating the translational labyrinth of the gut microbiota. [PDF]

Sci Rep
Jian C.
europepmc   +1 more source

Perioperative and Oncological Outcomes of Colorectal Cancer Surgery in Obese Patients: A Multicenter Retrospective Study

Annals of Gastroenterological Surgery, Volume 10, Issue 3, Page 748-759, May 2026.
The prognostic value of the log odds of positive lymph nodes (LODDS) across BMI categories was investigated in patients undergoing colorectal cancer resection. The exploratory evidence demonstrates that LODDS serves as a strong prognostic marker, and its adverse effect may be more pronounced in patients with higher BMI.
Kazuhiro Taguchi, Manabu Shimomura, Wataru Shimizu, Satoshi Ikeda, Masanori Yoshimitsu, Mohei Kouyama, Masahiro Nakahara, Hironori Kobayashi, Masatoshi Kochi, Yosuke Shimizu, Daisuke Sumitani, Shoichiro Mukai, Yuji Takakura, Yasuyo Ishizaki, Shinya Kodama, Masahiko Fujimori, Hiroshi Okuda, Takuya Yano, Tomoaki Bekki, Atsuhiro Watanabe, Saki Sato, Toshiyuki Moriuchi, Shohei Shiozaki, Kazuki Matsubara, Mizuki Yamaguchi, Tomohiro Adachi, Sho Ishikawa, Hideki Ohdan   +27 more
wiley   +1 more source

Exosomes derived from TGF-β1-modified mesenchymal stem cells protect septic mice by inducing macrophage M2 polarization. [PDF]

Mol Biol Rep
Liu F, Liu L, Zhao X, Zhou F.
europepmc   +1 more source

Independent Prognostic Significance of Perforation in Colorectal Cancer: Insights From a Propensity Score‐Matched Cohort Study

Annals of Gastroenterological Surgery, Volume 10, Issue 3, Page 779-791, May 2026.
Perforated colorectal cancer (PCC) is considered to have a poor prognosis; however, it remains unclear whether this is attributable to perforation itself or to perforation‐related clinicopathological factors. In this study, we analyzed prognosis using propensity score matching with perforation‐related factors and demonstrated that perforation is an ...
Yoshiaki Fujii, Shuhei Ueno, Yoshinaga Aoyama, Hiroyuki Imafuji, Takahisa Hirokawa, Hirotaka Miyai, Masahiro Kimura, Kenji Kobayashi, Shuji Takiguchi   +8 more
wiley   +1 more source

Nutritional Intervention With Perennial Ryegrass Modulates UA Metabolism in Goslings via Gut Microbiota-Antioxidant Pathway Modulation. [PDF]

Food Sci Nutr
Asif MA, Zulfiqar Z, Mustafa BE, Saif S, Wang Z, Cui Y, Hao S, Boshuai L, Shi Y.   +8 more
europepmc   +1 more source

GLP‐1 agonists and the gut microbiome: A bidirectional relationship

British Journal of Clinical Pharmacology, Volume 92, Issue 5, Page 1309-1325, May 2026.
Abstract Glucagon‐like peptide‐1 (GLP‐1) receptor agonists have transformed the management of type 2 diabetes mellitus (T2DM) and obesity, yet their interactions with the gut microbiome remain an emerging frontier in pharmacological and metabolic research.
Srinivas Kamath, Nicole S. L. Chan, Paul Joyce   +2 more
wiley   +1 more source

Dietary fiber reduces mortality from secondary sepsis in a murine model of <i>Clostridioides difficile</i> infection. [PDF]

iScience
Apgar M, Wall ES, Midura-Kiela M, Neff CP, Orlicky DJ, Lyon LM, Bernardazzi C, Martin CG, Gordon OM, Jimenez-Espinoza I, Flynn JK, Lozupone CA, Hazleton KZ.   +12 more
europepmc   +1 more source

Time Trends in the Prevalence of Hospital‐Diagnosed Chronic Diseases Among Stage I‐IV Colorectal Cancer Patients in Denmark (2002–2021): A Population‐Based Cross‐Sectional Study

Cancer Medicine, Volume 15, Issue 5, May 2026.
The prevalence of chronic diseases among colorectal cancer patients has increased markedly since 2002, rising from 36% to 51%, with more patients now presenting with chronic diseases than without at diagnosis. Metabolic diseases showed the most pronounced increase over time, whereas the prevalence of cardiopulmonary diseases among patients with one or ...
Jannik Wheler, Henrik Toft Sørensen, Rune Erichsen, Deirdre P. Cronin‐Fenton   +3 more
wiley   +1 more source