Results 71 to 80 of about 6,572 (187)

Utility of Combined Indigo Carmine and Red Dichromatic Imaging for Pit Pattern Diagnosis in Colorectal Lesions: A Comparison with Crystal Violet

DEN Open, Volume 6, Issue 1, April 2026.
With indigo carmine alone, pits appear navy blue and the surrounding mucosa pale red, colors roughly 90° apart on the color wheel. In contrast, IC + RDI renders pits violet and mucosa yellowcomplementary colors positioned 180° apart. This stronger chromatic contrast enhances visual discrimination, improving visibility score (3.17 vs.
Mitsunobu Saito, Shinji Yoshii, Takakazu Miyake, Tsukasa Yamakawa, Nobuaki Matsuda, Motonari Kamei, Tomomi Tateyama, Daisuke Takeuchi, Hiroshi Nakase   +8 more
wiley   +1 more source

Strategies and Educational Approaches to Colonoscopy Training: A Scoping Review

The Clinical Teacher, Volume 23, Issue 2, April 2026.
ABSTRACT Learning colonoscopy is challenging for inexperienced endoscopists, with competence typically achieved through observation, verbal instruction and hands‐on clinical training. Objective Various non‐clinical teaching models have been developed and are used globally.
Bernard K. Le, Jonathan S. Y. Hong, Daniel Lee   +2 more
wiley   +1 more source

Regional and Sex‐Dependent Immune Profiling Across the Colon in A Mouse Model of Ulcerative Colitis

The FASEB Journal, Volume 40, Issue 5, 15 March 2026.
At baseline, males have higher IL‐10, TH17 cytokines, and higher macrophages, neutrophils, and CD8+ cells in the medial and distal colon. Whereas females displayed increasing macrophages, lower TNF‐α, and higher IL‐1β, IL‐17A, and dendritic cells in the cecum and proximal colon.
Diane M. Tshikudi, Fola Olayinka‐Adefemi, Fazia Ait Zenati, Christine Zhang, Aaron J. Marshall, Charles N. Berstein, Jean‐Eric Ghia   +6 more
wiley   +1 more source

Cancer‐associated fibroblasts are associated with CD8+ T cell depletion and poor prognosis in colorectal adenocarcinoma: a multi‐omics and machine learning analysis

The Journal of Pathology: Clinical Research, Volume 12, Issue 2, March 2026.
Abstract Fibroblastic proliferation in various tumor microenvironments influences cancer survival through complex interactions with diverse immune responses. This study investigated the impact of histologically unique activated cancer‐associated fibroblasts (aCAFs) on survival outcomes and immune responses and examined their association with various ...
Myungsun Shim, One‐Zoong Kim, Byoung Kwan Son, Jung Ki Jo, Seung Wook Lee, Hong Sang Moon, Hyung Suk Kim, Mi Jung Kwon, Sung Hak Lee, Yung‐Kyun Noh, Kyueng‐Whan Min   +10 more
wiley   +1 more source

Fermented Lacticaseibacillus Paracasei Cultures Ameliorate Colitis by Modulating Microbiota‐Derived Tryptophan Metabolism and Macrophage Polarization

Advanced Science, Volume 13, Issue 13, 3 March 2026.
A solid‐state fermented probiotic (PYW) is developed using wheat bran as substrate, containing high viable Lacticaseibacillus paracasei and bioactive metabolites. PYW alleviates intestinal inflammation by gut microbiota composition, enriching indole derivatives, activating aryl hydrocarbon receptor signaling, and regulating macrophage polarization. PYW
Heng Zhang, Jingzhou Sun, Xin Zheng, Huiqing Yang, Aowen Xie, Yuxuan Ding, Yuxia Mei, Jinshan Li, Yuanliang Hu, Min Ren, Yangyang Liu, Yunxiang Liang   +11 more
wiley   +1 more source

USP35 Acts as a Deubiquitinating Enzyme for ID3 to Promote Immune Escape in Colorectal Cancer

Advanced Science, Volume 13, Issue 16, 18 March 2026.
USP35 stabilizes ID3 expression by deubiquitinating the K2/K30 site, thereby upregulating PD‐L1 and promoting immune escape in colorectal cancer. IU1, an inhibitor of USP35 enzyme activity, has been shown to inhibit USP35, thereby accelerating ID3 degradation, enhancing CD8+ T cell killing, and reversing the immunosuppressive microenvironment ...
Wenxin Chen, Ling Wang, Hongmei Fan, Lisheng Li, Lingyu Zhang, Ruoxin Li, Fang Liu, Fuli Wen, Yunbin Ye, Chuanzhong Huang   +9 more
wiley   +1 more source

m1A‐Dependent TRMT6/61A‐ARG2 Axis Drives Protumorigenic Senescence by Remodeling the Tumor Microenvironment

Advanced Science, Volume 13, Issue 13, 3 March 2026.
Uncovering a new layer of translational control, this study reveals how TRMT6/TRMT61A‐mediated tRNA‐m1A methylation drives pro‐tumorigenic senescence in colorectal cancer. By selectively enhancing ARG2 translation, this epitranscriptomic axis triggers an NF‐κB‐dependent SASP.
Tuoyang Li, Mingzhe Huang, Jinlin Cai, Xuan Li, Yaokang Xing, Rongzhao He, Zixiao Wan, Yingguo Gan, Ziming Li, Jingrong Weng, Yumo Xie, Yuanhui Wu, Xiaoxia Liu, Xiaolin Wang, Yanxin Luo, Meijin Huang, Jinxin Lin, Huichuan Yu   +17 more
wiley   +1 more source

Engineered Bacteria‐Vesicle Delivered Lactate Reprogramming Boosts Tumor Radiosensitivity

Advanced Science, Volume 13, Issue 16, 18 March 2026.
We engineered a bacterial‐vesicular dual‐delivery platform that targets LOx to colorectal tumors, enabling lactate clearance, immune microenvironment remodeling, and microbiota modulation. This microbe–metabolism synergistic strategy effectively sensitizes colorectal cancer to radiotherapy, offering a promising approach to overcome radioresistance ...
Fei Peng, Zhe Lei, Zhehao Zhang, Zhiyue Su, Chonghai Zhang, Huan Yang, Shu Liu, Mengyuan Hu, Yuhong Wang, Lingchuan Guo, Lin Hu, Kai Yang   +11 more
wiley   +1 more source

Antibacterial Applications of Black and Violet Phosphorus‐Based Biomaterials

Advanced NanoBiomed Research, Volume 6, Issue 3, March 2026.
Black and violet phosphorus‐based biomaterials exhibit broad‐spectrum antibacterial efficacy in various infections, including bone, skin, ocular, dental, lung, and sepsis cases. Their antibacterial mechanisms include physical disruption, light‐driven effects, targeted drug delivery, and enhanced composite strategies.
Zhuo Dai, Yu Zhang, Xiaoye Li, Ao He, Qiang Li, Weijun Xiu, Yongbin Mou, Heng Dong, Meng Ding   +8 more
wiley   +1 more source

From Synthesis to Therapeutics: Bioactive‐Coated Zein Nanoparticles in Drug Delivery

Biopolymers, Volume 117, Issue 2, March 2026.
ABSTRACT Polymeric zein nanoparticles (ZNP), derived from corn protein, are biodegradable drug carriers with high stability and low synthesis costs. Their amphiphilic nature allows efficient encapsulation of both hydrophilic and lipophilic drugs, making them promising for drug delivery.
Milena Ferreira de Lima, Andy Joel Taipe Huisa, Azael da Silva Neto, Clarice Beatriz Gonçalves Silva, Iago Dillion Lima Cavalcanti, Karolliny Barbosa de Araújo, Mariane Cajubá de Britto Lira‐Nogueira, Nereide Stela Santos Magalhães, Priscila Gubert   +8 more
wiley   +1 more source