Results 91 to 100 of about 6,026 (204)

Successful outpatient parenteral antibiotic therapy with cefiderocol for osteomyelitis caused by multi-drug resistant Gram-negative bacteria: a case report [PDF]

Objectives Post-traumatic osteomyelitis attributed to metallo-β-lactamase (MBL)-producing Gram-negative bacteria presents a challenging clinical scenario.
Hagel, Stefan, Rödel, Jürgen, Schellong, Paul, Spiegel, Christian, Wennek-Klose, Janett   +4 more
core   +1 more source

The challenge of treating infections caused by metallo-β-lactamase-producing gram-negative bacteria: a narrative review [PDF]

Review[Abstract] Gram-negative multidrug-resistant (MDR) bacteria, including Enterobacterales, Acinetobacter baumannii, and Pseudomonas aeruginosa, pose a significant challenge in clinical practice.
Bou, Germán, Hidalgo-Tenorio, Carmen, Martínez-Martínez, Luis, Oliver, Antonio, Rodríguez‑Aguirregabiria, Montserrat, Salavert, Miguel   +5 more
core   +2 more sources

Cefiderocol for the Treatment of Nosocomial Bloodstream Infections Caused by Stenotrophomonas maltophilia: A Case Series and Literature Review [PDF]

Introduction: The treatment of Stenotrophomonas maltophilia bloodstream infections (BSI) remains challenging due to the organism's intrinsic multidrug resistance and the potential side effects of commonly used first-line antibiotics.
Bartoletti, Michele, Bassetti, Matteo, Bavaro, Davide Fiore, Castaldo, Nadia, Corcione, Silvia, De Rosa, Francesco Giuseppe, Fumarola, Benedetta, Giacobbe, Daniele Roberto, Giannella, Maddalena, Mezzogori, Laura, Pagani, Gabriele, Pascale, Renato, Pinna, Simone Mornese, Scaglione, Vincenzo, Vena, Antonio   +14 more
core   +1 more source

The Efficacy of Topical Cefiderocol Treatment of Experimental Extensively Drug-Resistant Pseudomonas aeruginosa Keratitis Is Dependent upon the State of the Corneal Epithelium

Antibiotics
Background: An overlooked factor in the efficacy of topical antibiotics to treat bacterial keratitis is the state of the corneal epithelium. Recently, we evaluated topical cefiderocol for the treatment of extensively drug-resistant (XDR) Pseudomonas ...
Eric G. Romanowski, Jonathan B. Mandell, Vishal Jhanji, Robert M.Q. Shanks   +3 more
doaj   +1 more source

Meropenem-Vaborbactam as Salvage Therapy for Ceftazidime-Avibactam-, Cefiderocol-Resistant ST-512 Klebsiella pneumoniae-Producing KPC-31, a D179Y Variant of KPC-3 [PDF]

, 2021
A 68-year-old man had recurrent bacteremia by Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae resistant to ceftazidime-avibactam and cefiderocol.
Arcari G, Barnini S, Carattoli A, Falcone M, Giordano C, Leonildi A, Menichetti F., Tiseo G   +7 more
core  

Treatment of Carbapenem-Resistant Acinetobacter baumannii in Real Life (T-ACI): A Prospective Single-Center Observational Study

Antibiotics
Background: Carbapenem-resistant Acinetobacter baumannii (CRAB) poses significant challenges in healthcare due to its multidrug resistance and high mortality rates among critically ill patients. Results: We enrolled 45 patients.
Antonio Riccardo Buonomo, Riccardo Scotto, Nunzia Esposito, Giulio Viceconte, Nicola Schiano Moriello, Giulia Zumbo, Ilaria Vecchietti, Amedeo Lanzardo, Carmine Iacovazzo, Francesco Curcio, Emanuela Roscetto, Ivan Gentile   +11 more
doaj   +1 more source

When the Trojan horse is unable to reach inside the city: investigation of the mechanism of resistance behind the first reported cefiderocol-resistant E. coli in Canada

Microbiology Spectrum
Gram-negative metallo-β-lactamase-producing bacteria can be extremely problematic, especially when found to be extensively drug-resistant (XDR). Cefiderocol is a novel antimicrobial that has been shown to overcome most carbapenemases, with very rare ...
Kevin R. Barker, Gabriel W. Rebick, Ken Fakharuddin, Clayton MacDonald, Michael R. Mulvey, Laura F. Mataseje   +5 more
doaj   +1 more source

Emergence of cefiderocol resistance during therapy in NDM-5–producing Klebsiella pneumoniae isolates harboring siderophore receptors mutations

International Journal of Infectious Diseases
Cefiderocol, a siderophore-conjugated cephalosporine, is a promising drug used to treat infection with carbapenem-resistant gram-negative bacteria. Here, we report a case of pneumonia induced by multiple gram-negative pathogens, including a carbapenem ...
Luc Deroche, Albane Rozenholc, François Arrivé, Jean-Philippe Martellosio, Gwenaël Le Moal, Arnaud W. Thille, Olivier Barraud, Sandrine Marchand, Julien M. Buyck   +8 more
doaj   +1 more source

Treatment of critically ill patients with cefiderocol for infections caused by multidrug-resistant pathogens: review of the evidence [PDF]

, 2023
Rossolini, Gian Maria
core   +1 more source

Addressing antimicrobial resistance: Structural insights into cefiderocol’s mode of action and emerging resistance mechanisms

Journal of Infection and Public Health
Cefiderocol represents a significant advancement in the treatment of multidrug-resistant Gram-negative bacterial infections. Its unique uptake mechanism, leveraging bacterial iron transport pathways for membrane permeation, sets it apart from ...
Mohd Zulkifli Salleh
doaj   +1 more source