Results 91 to 100 of about 5,449 (190)

Challenges Facing Two Outbreaks of Carbapenem-Resistant Acinetobacter baumannii: From Cefiderocol Susceptibility Testing to the Emergence of Cefiderocol-Resistant Mutants

Carbapenem-resistant Acinetobacter baumannii (CRAB) infections are associated with poor outcomes depending on patient’s conditions, clinical severity and type of infection, and treatment is challenging given the limited therapeutic options ...
Mª José Asensio-Martín, Juan Carlos Ramos-Ramos, Mariana Díaz-Almirón, Eduardo Rubio-Mora, Mª Soledad Arellano-Serrano, Montserrat Rodríguez-Aguirregabiria, Fernando Lázaro-Perona, Juana Begoña Cacho-Calvo   +7 more
core   +1 more source

Emergence of cefiderocol resistance during therapy in NDM-5–producing Klebsiella pneumoniae isolates harboring siderophore receptors mutations

International Journal of Infectious Diseases
Cefiderocol, a siderophore-conjugated cephalosporine, is a promising drug used to treat infection with carbapenem-resistant gram-negative bacteria. Here, we report a case of pneumonia induced by multiple gram-negative pathogens, including a carbapenem ...
Luc Deroche, Albane Rozenholc, François Arrivé, Jean-Philippe Martellosio, Gwenaël Le Moal, Arnaud W. Thille, Olivier Barraud, Sandrine Marchand, Julien M. Buyck   +8 more
doaj   +1 more source

In Vitro Antibacterial Properties of Cefiderocol, a Novel Siderophore Cephalosporin, against Gram-Negative Bacteria

, 2018
Cefiderocol (CFDC; S-649266), a novel parenteral siderophore cephalosporin conjugated with a catechol moiety, has a characteristic antibacterial spectrum with a potent activity against a broad range of aerobic Gram-negative bacterial species, including ...
Masakatsu Tsuji, Naoki Ishibashi, Miki Takemura, Merime Ota, Shinsuke Toba, Toru Nishikawa, Akinobu Ito, Yoshinori Yamano, Satoshi Miyagawa, Shuhei Matsumoto, Rio Nakamura, Takafumi Sato, Naoki Kohira   +12 more
core   +1 more source

An immune-mediated effect of the antibiotic cefiderocol on LPS-induced acute lung injury

Antimicrobial Agents and Chemotherapy
This study examines the immune-modulatory effects of cefiderocol in a murine model of lipopolysaccharide (LPS)-induced acute lung injury (ALI). Cefiderocol pretreatment significantly reduced lung tissue damage, lowered pro-inflammatory cytokines, and ...
Min Hao, Ying Li, Yingmin Bi, Shuang Liu, Mohan Ju   +4 more
doaj   +1 more source

Cefiderocol. Summary and conclusions

Revista Española de Quimioterapia, 2022
Mensa, José, Barberán, José
openaire   +2 more sources

Addressing antimicrobial resistance: Structural insights into cefiderocol’s mode of action and emerging resistance mechanisms

Journal of Infection and Public Health
Cefiderocol represents a significant advancement in the treatment of multidrug-resistant Gram-negative bacterial infections. Its unique uptake mechanism, leveraging bacterial iron transport pathways for membrane permeation, sets it apart from ...
Mohd Zulkifli Salleh
doaj   +1 more source

Cefiderocol-Based Regimen for Acinetobacter NDM-1 Outbreak

Variable outcomes have been reported with cefiderocol in infections due to carbapenem-resistant Acinetobacter baumannii (CRAB). Nonetheless, it may be the only option for metallo-beta-lactamase-producing strains.
Francesco Peracchi, Noemi Lo Re, Giovanna Travi, Elisa Matarazzo, Giorgia Casalicchio, Marco Merli, Massimo Puoti, Alessandra Bielli, Fulvio Crippa, Chiara S. Vismara, Livia Tartaglione   +10 more
core   +1 more source

In vitro activity of cefiderocol against Gram-negative pathogens isolated from people with cystic fibrosis and bronchiectasis

Journal of Global Antimicrobial Resistance
: Objectives: Gram-negative pathogens causing respiratory infection in people with cystic fibrosis and bronchiectasis are becoming progressively more resistant to conventional antibiotics. Although cefiderocol is licenced for the treatment of infections
Michael M Tunney, J Stuart Elborn, Chloe S McLaughlin, Christopher M Longshaw   +3 more
doaj   +1 more source

Cefiderocol resistance genes identified in environmental samples using functional metagenomics [PDF]

Antibiotic resistance poses a global public health threat, which can originate from the transfer of environmental antibiotic resistance genes to pathogenic bacteria, as highlighted by the “One Health” framework. Cefiderocol is a siderophore cephalosporin
Klümper, Uli, Gschwind, Remi, Debroucker, Chloé, Jarquín-Díaz, Victor Hugo, Bonnet, Mehdi, Godron, Nicolas, Löber, Ulrike, Nahid, Fouzia, Zahra, Rabaab, Ruppé, Etienne, Tskhay, Faina, Wenne, Marcus, Berendonk, Thomas U., Bui-Hai, Maximilien, Bengtsson-Palme, Johan, Abramova, Anna, Kampouris, Ioannis D., El Aiba, Inès, Forslund-Startceva, Sofia K.   +18 more
core   +1 more source

In vitro resistance development gives insights into molecular resistance mechanisms against cefiderocol

Cefiderocol, a novel siderophore cephalosporin, demonstrates promising in vitro activity against multidrug-resistant Gram-negative bacteria, including carbapenemase-producing strains.
Schefberger, Katharina, Sanz-Codina, Maria, Lötsch, Felix, Spettel, Kathrin, Burgmann, Heinz, Willinger, Birgit, Harrison, Nicole, Zeitlinger, Markus, Lagler, Heimo, Kriz, Richard, Pichler, Alina   +10 more
core   +1 more source