Role of SCCmec type in resistance to the synergistic activity of oxacillin and cefoxitin in MRSA
β-lactam antibiotics target penicillin-binding proteins (PBPs) preventing peptidoglycan synthesis and this inhibition is circumvented in methicillin resistant Staphylococcus aureus (MRSA) strains through the expression of an additional PBP, named PBP2A ...
Nathalie T Reichmann +1 more
exaly +3 more sources
Ceftaroline pharmacokinetics/pharmacodynamics in the hollow-fibre model of Mycobacterium abscessus lung disease [PDF]
BACKGROUND: Guideline-based therapy (GBT) of Mycobacterium abscessus (MAB) lung disease (LD) achieves a sputum culture conversion rate in ∼35% of patients. The β-lactam antibiotics, imipenem and cefoxitin, are the cornerstone of GBT.
B.E. Ferro, S. Srivastava, T. Gumbo
doaj +2 more sources
Should Cefoxitin Non-Susceptibility in Ceftriaxone-Susceptible E. coli and K. pneumoniae Prompt Concerns Regarding Plasmid-Mediated AmpC Resistance? A Genomic Characterization and Summary of Treatment Challenges in Singapore [PDF]
Objectives: Plasmid-mediated AmpC beta-lactamases represent a growing clinical concern in Enterobacterales, with challenges in diagnostic approaches, limited data on clinical outcomes, and our incomplete understanding of their regulatory mechanisms ...
Jonathan Jinpeng Foo +8 more
doaj +2 more sources
Nasal Carriage of Staphylococcus Aureus in Different Age Groups Among Healthy School Children and its Antimicrobial Susceptibility Pattern [PDF]
Introduction: Staphylococcus aureus (S.aureus) is associated with increased risk for acquiring invasive disease. There exists an increasing prevalence of resistant community acquired S.aureus infections due to the nasal colonisation of S.aureus and ...
Dakshina Bisht, Varun Goel
doaj +1 more source
Minimum Inhibitory Concentration of Vancomycin against Methicillin Resistant Staphylococcus aureus Strains Isolated from a Tertiary Care Hospital [PDF]
Introduction: Methicillin Resistant Staphylococcus aureus (MRSA) is one major healthcare associated infection. Prevalence of MRSA and its antibiotic susceptibility changes from time to time.
Subi Das, Prithi Nair Kannambra
doaj +1 more source
Plasmid Derived AmpC Genotypes among the Multidrug Resistant Enterobacteriaceae Strains Isolated from Urine Samples in Southern India [PDF]
Introduction: The most common pathogens causing Urinary Tract Infections (UTI) in community and hospital settings are Enterobacteriaceae. Antibiotic resistance is a major problem worldwide because of an increase in the use of antibiotics.
P Ronni Mol +2 more
doaj +1 more source
Oxacillin resistance mediated by mecA in Staphylococcus lugdunensis is emerging in some geographic areas. We evaluated cefoxitin disk diffusion (DD) and a new oxacillin agar (supplemented with 2 μg/ml oxacillin and 2% sodium chloride) screen for the ...
Pak-Leung Ho +10 more
doaj +1 more source
Objectives: The objective of the current study was to compare the diagnostic methods of Oxacillin Disk Diffusion, Cefoxitin Disk Diffusion, Oxacillin Resistance Screening Agar Base, and CHROM Agar MRSA with the gold-standard method of Polymerase Chain ...
Nupur Gupta +3 more
doaj +1 more source
Genomic characterization of oxacillin-susceptible mecA-positive Staphylococcus aureus ST59 [PDF]
Objective. To characterize the genomes of oxacillin-susceptible mecA-positive Staphylococcus aureus ST59 isolated in St. Petersburg. Materials and Methods. Nine oxacillin-susceptible mecA-positive of S. aureus isolates (OS-MRSA) of ST59 were included
Gostev V.V. +9 more
doaj +1 more source
The comparative genomic analysis of Lactiplantibacillus plantarum YW11 (L. plantarum YW11) isolated from Tibetan kefir involves comparison of the complete genome sequences of the isolated strain with other closely related L. plantarum strains.
Tariq Aziz +9 more
doaj +1 more source

