Results 101 to 110 of about 1,647,355 (316)

Direct Involvement of Retinoblastoma Family Proteins in DNA Repair by Non-homologous End-Joining.

, 2015
Deficiencies in DNA double-strand break (DSB) repair lead to genetic instability, a recognized cause of cancer initiation and evolution. We report that the retinoblastoma tumor suppressor protein (RB1) is required for DNA DSB repair by canonical non ...
Spanswick, VJ, Maciej T. Luczynski, Rieger, Simone, Luczynski, Maciej T., Cook, Rebecca, Cook, R, Hartley, JA, Paul H. Huang, Victoria J. Spanswick, Huang, Paul H., Hartley, John A., John A. Hartley, Luczynski, MT, Rieger, S, Mittnacht, Sibylle, Mittnacht, S, Spanswick, Victoria J., Moquet, J, Huang, PH, Kai Rothkamm, Zoumpoulidou, Georgia, Jayne Moquet, Zoumpoulidou, G, Georgia Zoumpoulidou, Simone Rieger, Sibylle Mittnacht, Rothkamm, K, Rebecca Cook, Moquet, Jayne, Rothkamm, Kai   +29 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

DNA packaging and polycation length determine DNA susceptibility to free radical damage in condensed DNA

, 2023
In nature, DNA exists primarily in a highly compacted form. The compaction of DNA in vivo is mediated by cationic proteins; histone in somatic nuclei and protamines in sperm chromatin.
Daniel, Kirchhoff, Ehigbai, Oikeh, Yongmei, Wang, Jason, DeRouchey, Jesse, Ziebarth   +4 more
core   +1 more source

Cell-free circulating tumor DNA in cancer

Chinese Journal of Cancer, 2016
Cancer is a common cause of death worldwide. Despite significant advances in cancer treatments, the morbidity and mortality are still enormous. Tumor heterogeneity, especially intratumoral heterogeneity, is a significant reason underlying difficulties in
Zhen Qin, Vladimir A. Ljubimov, Cuiqi Zhou, Yunguang Tong, Jimin Liang   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Interspecies somatic cell nuclear transfer is dependent on compatible mitochondrial DNA and reprogramming factors [PDF]

, 2011
Interspecies somatic cell nuclear transfer (iSCNT) involves the transfer of a nucleus or cell from one species into the cytoplasm of an enucleated oocyte from another.
St. John Justin C., Dickinson Adam, Daniel A Mitchell, Yan Jiang, Kelly Richard, Peters Amy, Fulka, Helena, Helena Fulka, Justin C. St. John, Dickinson, Adam, St. John, Justin C., Adam Dickinson, Daniel A. Mitchell, Justin C St John, Jiang Yan, Fulka Helena, Kelly, Richard D. W., Mitchell Daniel A., Mitchell, Daniel A., Peters, Amy, Richard Kelly, Jiang, Yan, Amy Peters   +22 more
core   +1 more source

Figure S5 from The Origin of Highly Elevated Cell-Free DNA in Healthy Individuals and Patients with Pancreatic, Colorectal, Lung, or Ovarian Cancer

, 2023
Austin K. Mattox, Christopher Douville, Yuxuan Wang, Maria Popoli, Janine Ptak, Natalie Silliman, Lisa Dobbyn, Joy Schaefer, Steve Lu, Alexander H. Pearlman, Joshua D. Cohen, Jeanne Tie, Peter Gibbs, Kamel Lahouel, Chetan Bettegowda, Ralph H. Hruban, Cristian Tomasetti, Peiyong Jiang, K.C. Allen Chan, Yuk Ming Dennis Lo, Nickolas Papadopoulos, Kenneth W. Kinzler, Bert Vogelstein   +22 more
openalex   +1 more source

Cell-Free DNA as a Prognostic Biomarker for Monitoring Muscle-Invasive Bladder Cancer [PDF]

, 2022
Raquel Carrasco, Mercedes Ingelmo‐Torres, Ascensión Gómez, Ramón Trullás, Fiorella L. Roldán, Tarek Ajami, Davinia Moreno, Leonardo Rodríguez‐Carunchio, Antonio Alcaraz, Laura Izquierdo, Lourdes Mengual   +10 more
openalex   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Optical Nanosensor Architecture for Cell-Signaling Molecules Using DNA Aptamer-Coated Carbon Nanotubes

, 2011
We report a novel optical biosensor platform using near-infrared fluorescent single-walled carbon nanotubes (SWNTs) functionalized with target-recognizing aptamer DNA for noninvasively detecting cell-signaling molecules In real time.
Rickus, Jenna, Jong Hyun Choi, Choi, Jong Hyun, Sauffer, M. Dane, Benjamin A. Baker, Salgado, Janette, Jaroch, David, Janette Salgado, D. Marshall Porterfield, M. Dane Sauffer, David Jaroch, Jenna L. Rickus, Cha, Tae-Gon, Tae-Gon Cha, Baker, Benjamin A., Porterfield, D. Marshall   +15 more
core   +2 more sources