Results 151 to 160 of about 1,374,920 (267)

Discovering cell-active BCL6 inhibitors: effectively combining biochemical HTS with multiple biophysical techniques, X-ray crystallography and cell-based assays. [PDF]

Sci Rep, 2022
Pierrat OA, Liu M, Collie GW, Shetty K, Rodrigues MJ, Le Bihan YV, Gunnell EA, McAndrew PC, Stubbs M, Rowlands MG, Yahya N, Shehu E, Talbot R, Pickard L, Bellenie BR, Cheung KJ, Drouin L, Innocenti P, Woodward H, Davis OA, Lloyd MG, Varela A, Huckvale R, Broccatelli F, Carter M, Galiwango D, Hayes A, Raynaud FI, Bryant C, Whittaker S, Rossanese OW, Hoelder S, Burke R, van Montfort RLM.   +33 more
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Comparison of commercial and in-house tissue-based and cell-based assays for the detection of autoantibodies targeting neuronal surface proteins: a prospective cohort study. [PDF]

Front Immunol
Goncalves D, Benaiteau M, Rogemond V, Closs S, Pinto AL, Dhairi M, Villard M, Picard G, Fabien N, Honnorat J.   +9 more
europepmc   +1 more source

Direct and Indirect Antioxidant Effects of Selected Plant Phenolics in Cell-Based Assays. [PDF]

Molecules, 2021
Treml J, Večeřová P, Herczogová P, Šmejkal K.   +3 more
europepmc   +1 more source

Cell-based assays for C99 interactions-Tango assays

BIO-PROTOCOL, 2017
Yan Yan, Ting-Hai Xu, Kaleeckal G. Harikumar, Laurence J. Miller   +3 more
openaire   +2 more sources

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Performance of cryptogenic new onset refractory status epilepticus score in a Brazilian cohort after testing for antineuronal antibodies with tissue-based and cell-based assays. [PDF]

Epilepsia
Ferreira JHF, Gomes AM, Zetehaku AC, Marinho TF, Toso FF, Disserol CCD, Krueger MB, Santos MLSF, Juliano AFB, Barbosa TL, de Almeida Rocha LJ, Gameleira FT, Paolilo RB, Daccach V, Gomes JPI, Lin K, da Nóbrega AW, Marmentini EL, Fusão EF, de Cuffa A, Tavares GLA, Dias RM, Diniz SSL, Siquineli F, Braga-Neto P, Nobrega PR, Sanders LP, Carvalho FMM, Pereira RBR, de Melo ES, de Miranda Henriques-Souza AM, de Oliveira Godeiro C, Arambula OG, de Souza E Silva FN, Couto KO, Danieli D, Seitz KW, Dellavance A, Endmayr V, Höftberger R, Andrade LEC, Caboclo LO, Dutra LA.   +42 more
europepmc   +1 more source

New Modalities of 3D Pluripotent Stem Cell-Based Assays in Cardiovascular Toxicity. [PDF]

Front Pharmacol, 2021
Orsolits B, Kovács Z, Kriston-Vizi J, Merkely B, Földes G.   +4 more
europepmc   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Evaluation of the Antioxidant Properties and Bioactivity of Koroneiki and Athinolia Olive Varieties Using In Vitro Cell-Free and Cell-Based Assays. [PDF]

Int J Mol Sci
Gkasdrogka M, Tekos F, Skaperda Z, Vardakas P, Kouretas D.   +4 more
europepmc   +1 more source