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High-throughput cell-based assays in yeast

Drug Discovery Today, 2002
With the sequencing of many genomes now completed, biologists are faced with the challenge of deciphering the function and association of an immense number of predicted proteins. Comprehension of the networks of proteins and chemicals that comprise the cells and tissues of an organism, and the specific roles of proteins in these networks, will be a ...
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Cell‐based assays in GPCR drug discovery

Biotechnology Journal, 2008
AbstractG protein‐coupled receptors (GPCRs) transmit extracellular signals into the intracellular space, and play key roles in the physiological regulation of virtually every cell and tissue. Characteristic for the GPCR superfamily of cell surface receptors are their seven transmembrane‐spanning α‐helices, an extracellular N terminus and intracellular ...
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Cell Based Assays for Drug Screening

1997
A CRE-alkaline Phosphatase reporter construct has been introduced into a mammalian cell line to investigate signal transduction pathways used by the calcitonin receptor. Calcitonin activated alkaline Phosphatase production in the CRE-reporter cell line.
Elizabeth Keenan +3 more
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Cell-based assays