Results 331 to 340 of about 836,270 (361)

"Kill" the messenger: Targeting of cell-derived microparticles in lupus nephritis.

Autoimmunity Reviews, 2016
Immune complex (IC) deposition in the glomerular basement membrane (GBM) is a key early pathogenic event in lupus nephritis (LN). The clarification of the mechanisms behind IC deposition will enable targeted therapy in the future. Circulating cell-derived microparticles (MPs) have been proposed as major sources of extracellular autoantigens and ICs and
C. Nielsen, N. Rasmussen, N. Heegaard, S. Jacobsen   +3 more
semanticscholar   +6 more sources

Circulating Cell-Derived Microparticles in Crohn?s Disease [PDF]

Digestive Diseases and Sciences, 2005
Procoagulant membrane microparticles can be released from activated or apoptotic cells in response to various environmental stimuli. The aim of this study was to investigate the presence of microparticles in Crohn's disease and to assess their variations after infliximab therapy.
P. Chamouard, Michel Lessard, Dominique Desprez, Carole Gidon-Jeangirard, Bénédicte Hugel, Lelia Grunebaum, Corinne Kunzelmann, René Baumann, Jean-Marie Freyssinet   +8 more
openaire   +2 more sources

Red cell-derived microparticles (RMP) as haemostatic agent

Thrombosis and Haemostasis, 2013
SummaryAmong circulating cell-derived microparticles, those derived from red cells (RMP) have been least well investigated. To exploit potential haemostatic benefit of RMP, we developed a method of producing them in quantity, and here report on their haemostatic properties. High-pressure extrusion of washed RBC was employed to generate RMP.
W. Jy, Max E Johansen, Carlos J. Bidot, L. Horstman, Y. Ahn   +4 more
semanticscholar   +4 more sources

Cell‐derived microparticles and von Willebrand factor in Brazilian renal transplant recipients

Nephrology, 2019
This study was aimed at investigating platelet‐derived microparticles (PMP), endothelium cell‐derived microparticles (EMP) and von Willebrand factor (VWF) according to renal function and time post‐transplant.
S. R. Martins, L. V. Alves, C. Cardoso, L. Silva, F. F. Nunes, Fernando das Mêrces de Lucas Júnior, A. C. Simões e Silva, L. Dusse, P. Alpoim, A. P. L. Mota   +9 more
semanticscholar   +1 more source

Influence of Cell-Derived Microparticles on Thromboelastography.

Blood, 2010
Abstract Abstract 3698 Background. Thromboelastography (TEG) is a method of analyzing coagulation commonly used to assess pre- and perioperative bleeding risk. We have been interested in the role of cell-derived microparticles (MP) in coagulation and in this study, examined correlations
Mirian Yaniz, Max E Johansen, Lawrence L. Horstman, Martha Q. Gonzalez, Wenche Jy, Carlos J. Bidot, Yeon S. Ahn   +6 more
openaire   +2 more sources

Transformation of cell-derived microparticles into quantum-dot-labeled nanovectors for antitumor siRNA delivery.

Angewandte Chemie, 2015
Cell-derived microparticles (MPs) have been recently recognized as critical intercellular information conveyors. However, further understanding of their biological behavior and potential application has been hampered by the limitations of current ...
Gang Chen, Jun‐yi Zhu, Zhiling Zhang, Wei Zhang, Jian-Gang Ren, Min Wu, Zheng-Yuan Hong, Cheng Lv, D. Pang, Yi-Fang Zhao   +9 more
semanticscholar   +1 more source

Circulating Cell-Derived Microparticles in Women with Pregnancy Loss

American Journal of Reproductive Immunology, 2011
To analyze cell-derived microparticles (cMP) in pregnancy loss (PL), both recurrent miscarriages (RM) and unexplained fetal loss (UFL).Non-matched case-control study was performed at Vall d'Hebron Hospital. Cell-derived microparticles of 53 PL cases, 30 with RM, 16 with UFL, and 7 (RM + UFL), were compared to 38 healthy pregnant women.
Carles Palacio-Garcia, Luis Cabero-Roura, Jaume Alijotas-Reig, Miquel Vilardell-Tarrés, Cristina Zarzoso, Immaculada Farran-Codina   +5 more
openaire   +2 more sources

Cell‐Derived Microparticles and Exosomes in Neuroinflammatory Disorders

2007
All blood cells and the vascular endothelium shed microparticles (MP) from their plasma membranes when suitably stimulated, and assay of MP in patient blood has found increasing application to the monitoring of disease states. In addition, mounting evidence suggests that MP are not mere epiphenomena but play significant roles in the pathophysiology of ...
Yeon S. Ahn, J. Steven Alexander, Alireza Minagar, Joaquin J. Jimenez, Lawrence L. Horstman, Wenche Jy, Carlos J. Bidot   +6 more
openaire   +3 more sources

Pyroptotic cell-derived microparticle: An atherogenic factor in infectious diseases

Medical Hypotheses, 2021
Chronic infection is considered a risk factor for atherosclerosis. The link between infectious agents and atherosclerosis is manifested by the presence of infection-induced pyroptotic cells in atherosclerotic lesions. Pyroptosis is an inflammatory form of programmed cell death that occurs most frequently upon infection. However, inflammation is not the
Qin-Hui Tuo, Shao-wei Sun, Duan-Fang Liao, Xiaoyong Lei, Gui-qiong Zheng, Wen-juan Tong   +5 more
openaire   +2 more sources

Cell-Derived Microparticles/Exosomes in Neuroinflammation

2017
The roles of cell-derived microparticles (MP) in neuroinflammatory disorders are increasingly recognized as fundamental. Exosomes are now established as a well-defined subclass of MP. A major function is transport of many inflammatory mediators, now including gene-modulating RNA transcripts.
Lawrence L. Horstman, Yeon S. Ahn, Wenche Jy   +2 more
openaire   +2 more sources