Results 71 to 80 of about 36,354 (283)

The volatile anesthetic isoflurane increases endothelial adenosine generation via microparticle ecto-5'-nucleotidase (CD73) release.

PLoS ONE, 2014
Endothelial dysfunction is common in acute and chronic organ injury. Isoflurane is a widely used halogenated volatile anesthetic during the perioperative period and protects against endothelial cell death and inflammation.
Mihwa Kim, Ahrom Ham, Katelyn Yu-Mi Kim, Kevin M Brown, H Thomas Lee   +4 more
doaj   +1 more source

Reversing insufficient photothermal therapy-induced tumor relapse and metastasis by regulating cancer-associated fibroblasts

Nature Communications, 2022
Photothermal therapy (PTT) has emerged as a promising approach for cancer treatment. Here, in preclinical cancer models, the authors show that PTT efficacy could be improved using tumor cell-derived microparticles that co-deliver the photosensitizer ...
Xin Li, Tuying Yong, Zhaohan Wei, Nana Bie, Xiaoqiong Zhang, Guiting Zhan, Jianye Li, Jiaqi Qin, Jingjing Yu, Bixiang Zhang, Lu Gan, Xiangliang Yang   +11 more
doaj   +1 more source

Macrophages Discriminate Glycosylation Patterns of Apoptotic Cell-derived Microparticles [PDF]

Journal of Biological Chemistry, 2012
Inappropriate clearance of apoptotic remnants is considered to be the primary cause of systemic autoimmune diseases, like systemic lupus erythematosus. Here we demonstrate that apoptotic cells release distinct types of subcellular membranous particles (scMP) derived from the endoplasmic reticulum (ER) or the plasma membrane.
Rostyslav O, Bilyy, Tanya, Shkandina, Andriy, Tomin, Luis E, Muñoz, Sandra, Franz, Volodymyr, Antonyuk, Yuriy Ya, Kit, Matthias, Zirngibl, Barbara G, Fürnrohr, Christina, Janko, Kirsten, Lauber, Martin, Schiller, Georg, Schett, Rostyslav S, Stoika, Martin, Herrmann   +14 more
openaire   +2 more sources

In Vitro and In Vivo Safety of Hyaluronic Acid-Decorated Microparticles for Intravitreal Injection of Palmitoylethanolamide, Citicoline, or Glial-Cell-Derived Neurotrophic Factor

, 2023
The treatment of posterior eye segment diseases through intravitreal injection requires repeated injections of an active molecule, which may be associated with serious side effects and poor patient compliance.
Laura Mayol (16734351), Emilie Picard (79189), Fatima Domenica Elisa De Palma, Emilie Picard, Valentina Mollo (16012639), Marco Biondi, Fabiola Spitaleri (16734348), Maria Chiara Maiuri, Danilo Aleo (2534896), Marie Christine Naud, Marco Biondi (10996268), Danilo Aleo, Valentina Mollo, Marie Christine Naud (16734345), Francine Behar-Cohen, Guido Kroemer (82802), Fabiola Spitaleri, Teresa Silvestri (16402179), Maria Chiara Maiuri (15113251), Alejandra Daruich, Alejandra Daruich (16734339), Fatima Domenica Elisa De Palma (16734342), Laura Mayol, Teresa Silvestri, Guido Kroemer, Francine Behar-Cohen (64434)   +25 more
core   +1 more source

Decellularized Extracellular Matrix (dECM) in Tendon Regeneration: A Comprehensive Review

Advanced Healthcare Materials, EarlyView.
Decellularized Extracellular Matrix (dECM) offers a promising solution by replicating the native tendon microenvironment and promoting regeneration. This review highlights advances in the decellularization methods, as well as their integration with emerging technologies and translational progress in tendon tissue engineering.
Kumaresan Sakthiabirami, Yeonwoo Park, Seong Kyeong Jo, Min Hee Kim, Jae Hwang Song   +4 more
wiley   +1 more source

Breast Cancer-Derived Microparticles Reduce Cancer Cell Adhesion, an Effect Augmented by Chemotherapy

, 2020
Tumor cell heterogeneity is primarily dictated by mutational changes, sometimes leading to clones that undergo a metastatic switch. However, little is known about tumor heterogeneity following chemotherapy perturbation.
Leonel M. Sagredo, Tamar Geiger, Shimrit Avraham, Dvir Shechter, David Loven, Yuval Shaked, Abhishek Mukherjee, Haguy Wolfenson, Michal Harel, Elad Prinz, Veronique Orian-Rousseau   +10 more
core   +1 more source

Packed Hydrogel Microfibers as Scaffolds Supporting Dynamic Cellular Behavior and Biomaterial Inks in 3D Printing

Advanced Healthcare Materials, EarlyView.
Packed hydrogel microfiber (PHM) materials consist of flexible and high aspect ratio hydrogel components that, as a bulk material, are simultaneously mechanically robust and dynamic. Cells cultured in or on PHM scaffolds can be influenced by topographical cues or interact with a dynamic environment that permits cell spreading and multicellular ...
M. Gregory Grewal, Remington M. Martinez, Georgia T. Helein, Montserrath G. Ibarra Rivera, Rodolfo Martinez Jr., Jenna L. Sumey, Steven R. Caliari, Christopher B. Highley   +7 more
wiley   +1 more source

A Systematic Study of GelMA‐Carbopol Bioinks for High‐Fidelity Extrusion 3D Bioprinting at Physiological Temperatures

Advanced Healthcare Materials, EarlyView.
Gonzalez Martinez and collaborators develop a strategy to formulate high performance GelMA‐based bioinks with low solids contents. The resulting bioinks enable 3D bioprinting at 37 °C of high‐fidelity structures with tunable mechanical properties that support high cell viability and function.
David A. González‐Martínez, Aidee V. Arizpe Tafoya, Eduardo González‐Martínez, Mabel Barreiro Carpio, Laura Daniela Serrano Andrade, Christopher T. N. Chow, Mohammadhossein Dabaghi, Jeremy A. Hirota, Jose M. Moran‐Mirabal   +8 more
wiley   +1 more source

Microgel‐Based 3D Bioprinting: A Convergent Strategy Integrating Material Design, Jamming Dynamics, and Biological Function

Advanced Healthcare Materials, EarlyView.
Microgel‐based 3D printed constructs represent a compelling and versatile innovation for engineering architecturally complex, dynamically remodelable, and biocompatible structures with high structural fidelity and bioactivity. By integrating material design, biofabrication, and biological function, these systems enable the development of adaptive ...
Elena Ghighină, Andreea Ioana Dinu, Jana Ghițman   +2 more
wiley   +1 more source

Neutrophil‐Mimetic MRI Enables Ultra‐Early Detection of Vascular Inflammation After Stroke

Advanced Healthcare Materials, EarlyView.
In this study, we developed neutrophil‐mimetic MRI probes that detect ultra‐early neuroinflammation following ischemic stroke by targeting E‐selectin. Within seconds of their injection, these microparticles mimic initial leukocyte adhesion to the activated cerebral endothelium.
Marion Isabelle Morvan, Damien Levard, Eloïse Lemarchand, Amal Boublay, Charly Helaine, Jolan Malherbe, Mikaël Naveau, Didier Goux, Igor Khalin, Ankita Talukdar, Cheun Pelleter, Charlène Jacqmarcq, Erwan Baudron, Isabelle Bardou, Sara Martinez de Lizarrondo, Maxime Gauberti, Denis Vivien, Antoine Philippe Fournier   +17 more
wiley   +1 more source