Results 121 to 130 of about 88,541,361 (296)

Subcellular Dynamics and Role of Arabidopsis β-1,3-Glucanases in Cell-to-Cell Movement of Tobamoviruses

Molecular Plant-Microbe Interactions, 2013
β-1,3-Glucanases (BG) have been implicated in enhancing virus spread by degrading callose at plasmodesmata (Pd). Here, we investigate the role of Arabidopsis BG in tobamovirus spread.
Raul Zavaliev, Amit Levy, Abed Gera, Bernard L. Epel   +3 more
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Intra-lineage plasticity and functional reprogramming maintain natural killer cell repertoire diversity

, 2019
Natural killer (NK) cell repertoires are made up of phenotypically distinct subsets with different functional properties. The molecular programs involved in maintaining NK cell repertoire diversity under homeostatic conditions remain elusive.
Malmberg, K-J, Ask, Eivind Heggernes, Goodridge, Jodie, Lorenz, S, Lorenz, Susanne, Goodridge, JP, Clancy, T, Malmberg, Karl-Johan, Pfefferle, A,, Sohlberg, Ebba, Sohlberg, E,, Jacobs, Benedikt Marcel, Netskar, Herman, Netskar, H, Ask, EH, Pfefferle, Aline, Clancy, Trevor, Jacobs, B   +17 more
core   +1 more source

Integrated single-cell RNA sequencing analysis reveals phenotypic differences between blood endothelial cells from oral mucosa and skin

European Journal of Cell Biology
Introduction: The oral mucosa and the skin are two barrier tissues acting as the first line of defense protecting our body from external forces and invaders. Although these tissues are histologically quite similar, differences have been described related
Lisa-Lee Brüske, Sanne Roffel, Michael de Kok, Merel Rijnsburger, Helga E. de Vries, Susan Gibbs   +5 more
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

LIN28 Regulates Stem Cell Metabolism and Conversion to Primed Pluripotency

, 2016
The RNA-binding proteins LIN28A and LIN28B play critical roles in embryonic development, tumorigenesis, and pluripotency, but their exact functions are poorly understood.
Wu, Zhaoting, Onder, Tamer, Tintara, Supisara, Xia, Qing, Asara, John M., Ratanasirintrawoot, Sutheera, Collins, James J., Ng, Shyh-Chang, Trapnell, Cole, Sliz, Piotr, Chandrasekaran, Sriram, Cacchiarelli, Davide, Wang, Longfei, Mikkelsen, Tarjei, Daley, George Q., Marto, Jarrod A., Teitell, Michael A., Ficarro, Scott B., Ross, Christian A., Shinoda, Gen, Zhang, Jin, Li, Hu, Xie, Wen, Yu, Chunxiao, Loh, Yuin-Han, Cahan, Patrick, Seligson, Marc   +26 more
core   +1 more source

MAP4K4 inhibition promotes survival of human stem cell derived cardiomyocyte and reduces infarct size in vivo [PDF]

, 2019
Heart disease is a paramount cause of global death and disability. Although cardiomyocyte death plays a causal role and its suppression would be logical, no clinical counter-measures target the responsible intracellular pathways. Therapeutic progress has
Paiva, MA, Michael, LH, Song, W, Kanayaganam, S, Xie, M, Taffet, GE, Harding, SE, Pavanello, L, Aqil, R, Bellahcene, M, Maifosie, E, Jarvis, A, Wang, SC, Tralau-Stewart, C, Habib, J, Perrior, T, Narasimham, P, Fiedler, Lorna, Newton, G, Golforoush, PA, Noseda, M, Sampson, RD, Bellahcene, Mohamed, Tan, T, Fiedler, LR, Golforoush, Pelin, Jenkins, M, Sano, M, Schneider, MD, Entman, ML, Chapman, K, Faust, D, Tan, T-H, Harding, Sian, Noseda, Michela, Sanmugalingam, D, Schneider, Michael, Stuckey, DJ, Yan, R, Maifoshie, E, Narasimhan, P, Low, CMR, Harada, M   +42 more
core   +1 more source

Fig mosaic emaravirus p4 protein is involved in cell-to-cell movement

Journal of General Virology, 2013
Fig mosaic virus (FMV), a member of the newly formed genus Emaravirus, is a segmented negative-strand RNA virus. Each of the six genomic FMV segments contains a single ORF: that of RNA4 encodes the protein p4. FMV-p4 is presumed to be the movement protein (MP) of the virus; however, direct experimental evidence for this is lacking ...
Kazuya, Ishikawa, Kensaku, Maejima, Ken, Komatsu, Osamu, Netsu, Takuya, Keima, Takuya, Shiraishi, Yukari, Okano, Masayoshi, Hashimoto, Yasuyuki, Yamaji, Shigetou, Namba   +9 more
openaire   +2 more sources

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Molecular Dissection of the Mechanism by Which Potexvirus Triple Gene Block Proteins Mediate Cell-to-Cell Transport of Infectious RNA

Molecular Plant-Microbe Interactions, 1998
The triple gene block (TGB; consisting of proteins TGB1–3) and coat protein (CP) of white clover mosaic potexvirus (WClMV) are required for cell-to-cell movement of viral RNA.
Tony J. Lough, Khalid Shash, Beatriz Xoconostle-Cázares, Katrina R. Hofstra, David L. Beck, Ezequiel Balmori, Richard L. S. Forster, William J. Lucas   +7 more
doaj   +1 more source