Results 131 to 140 of about 1,877,814 (364)

Integration of single‐cell and bulk RNA‐sequencing data reveals the prognostic potential of epithelial gene markers for prostate cancer

open access: yesMolecular Oncology, EarlyView.
Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley   +1 more source

Causal associations of white blood cell count and sudden sensorineural hearing loss: a bidirectional and multivariable Mendelian randomization study

open access: yesFrontiers in Neurology
BackgroundNumerous compelling observational studies have demonstrated a plausible correlation between the white blood cell count and the susceptibility to sudden sensorineural hearing loss (SSNHL).
Ling Zhang   +7 more
doaj   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

open access: yesMolecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin   +14 more
wiley   +1 more source

Assessment of subclinical mastitis diagnostic accuracy by differential cell count in individual cow milk

open access: yesItalian Journal of Animal Science, 2019
The progressive decrease of mean SCC in dairy herds worldwide is affecting SCC accuracy as a subclinical mastitis marker. This evidence supports studies aiming to apply differential cell count (DSCC) as a tool to identify mastitis.
Alfonso Zecconi   +4 more
doaj   +1 more source

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

open access: yesMolecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi   +5 more
wiley   +1 more source

Absolute lymphocyte count: A cost-effective method of monitoring HIV-infected individuals

open access: yesIndian Journal of Pathology and Microbiology, 2011
Aim: Depletion of CD4 cell count is a hallmark of disease progression in AIDS. CD4 cell count is essential for physicians to decide about the timing of initiation of antiretroviral therapy (ART) and for prophylaxis of opportunistic infections.
A Kakar   +6 more
doaj   +1 more source

People, Penguins and Petri Dishes: Adapting Object Counting Models To New Visual Domains And Object Types Without Forgetting [PDF]

open access: yesarXiv, 2017
In this paper we propose a technique to adapt a convolutional neural network (CNN) based object counter to additional visual domains and object types while still preserving the original counting function. Domain-specific normalisation and scaling operators are trained to allow the model to adjust to the statistical distributions of the various visual ...
arxiv  

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