Results 61 to 70 of about 1,877,814 (364)

Augmented Mitotic Cell Count using Field Of Interest Proposal

, 2018
Histopathological prognostication of neoplasia including most tumor grading systems are based upon a number of criteria. Probably the most important is the number of mitotic figures which are most commonly determined as the mitotic count (MC), i.e ...
Aubreville, Marc, Bertram, Christof A., Klopfleisch, Robert, Maier, Andreas   +3 more
core   +1 more source

miRNA‐29 regulates epidermal and mesenchymal functions in skin repair

FEBS Letters, EarlyView.
miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan, Rosa Sanchez‐Alvarez, Chiho Kambara, Poojitha Rajasekar, Yuluang Wang, François Halloy, Jonathan Hall, Hans‐Jürgen Stark, Iris Martin, Petra Boukamp, Svitlana Kurinna   +10 more
wiley   +1 more source

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

A rapid, cost-effective method for counting human embryonic stem cell numbers as clumps

BioTechniques, 2009
Enumeration of human embryonic stem cell (hESC) numbers through single cell digestion can be time consuming especially in high-throughput or multi-factorial analysis containing 50+ samples.
Andrew B.J. Prowse, Ernst J. Wolvetang, Peter P. Gray   +2 more
doaj   +1 more source

A mathematical framework for raw counts of single-cell RNA-seq data analysis [PDF]

arXiv, 2020
Single-cell RNA-seq data are challenging because of the sparseness of the read counts, the tiny expression of many relevant genes, and the variability in the efficiency of RNA extraction for different cells. We consider a simple probabilistic model for read counts, based on a negative binomial distribution for each gene, modified by a cell-dependent ...
arxiv  

Influence of somatic cell count and breed on capillary electrophoretic protein profiles of ewes’ milk: A chemometric study [PDF]

, 2007
Producción CientíficaBulk tank ewe milk from the Assaf, Castellana, and Churra breeds categorized into 3 somatic cell count (SCC) groups (2,500,000 cells/mL) was used to investigate changes in chemical composition and capillary electrophoresis protein ...
Revilla Martín, Isabel, Rodríguez Nogales, José Manuel, Vivar Quintana, Ana María   +2 more
core   +1 more source

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

Development of a motion-based cell-counting system for Trypanosoma parasite using a pattern recognition approach

BioTechniques, 2019
Automated cell counters that utilize still images of sample cells are widely used. However, they are not well suited to counting slender, aggregate-prone microorganisms such as Trypanosoma cruzi.
Yuko Takagi, Hirokazu Nosato, Motomichi Doi, Koji Furukawa, Hidenori Sakanashi   +4 more
doaj   +1 more source

Systematically designing better instance counting models on cell images with Neural Arithmetic Logic Units [PDF]

arXiv, 2020
The big problem for neural network models which are trained to count instances is that whenever test range goes high training range generalization error increases i.e. they are not good generalizers outside training range. Consider the case of automating cell counting process where more dense images with higher cell counts are commonly encountered as ...
arxiv  

Gut microbiota in HIV-pneumonia patients is related to peripheral CD4 counts, lung microbiota, and in vitro macrophage dysfunction. [PDF]

, 2019
Pneumonia is common and frequently fatal in HIV-infected patients, due to rampant, systemic inflammation and failure to control microbial infection. While airway microbiota composition is related to local inflammatory response, gut microbiota has been ...
Byanyima, Patrick, Chang, Emily, Davis, J Lucian, Fadrosh, Douglas W, Fong, Serena, Huang, Laurence, Kaswabuli, Sylvia, Lin, Din L, Lynch, Susan V, McCauley, Kathryn, Musisi, Emmanuel, Sanyu, Ingvar, Shenoy, Meera K, Worodria, William, Zawedde, Josephine   +14 more
core   +2 more sources