Results 171 to 180 of about 17,149,914 (409)

The chloroform fraction of Dracontium spruceanum modulates gene expression in gastric cancer stem cells

Scientific Reports
Gastric cancer is the fourth most common cancer globally and the leading cause of cancer-related deaths in Peru. Current synthetic treatments often fail to distinguish cancerous cells from healthy cells, resulting in severe side effects and drug ...
Salyoc Tapia-Rojas, José Amiel-Pérez, Alejandro Fukusaki-Yoshizawa, Obert Marín-Sánchez, Ana Mayanga-Herrera   +4 more
doaj   +1 more source

Effects of Leucaena leucocephala (Lam.) de Wit Leaves Extracts in Culture of Human Umbilical Vein Cells [PDF]

, 2017
Ratikorn Chatchanayuenyong, Patcharawan Sujayanont, Auranut Vuttivirojana   +2 more
openalex   +1 more source

Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids

Current Protocols in Cell Biology, 2006
C. Théry, S. Amigorena, G. Raposo, A. Clayton   +3 more
semanticscholar   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Genetically engineered cardiac pacemaker: stem cells transfected with HCN2 gene and myocytes - a model

, 2005
Artificial biological pacemakers were developed and tested in canine ventricles. Next steps will require obtaining oscillations sensitive to external regulations, and robust with respect to long term drifts of expression levels of pacemaker currents and ...
Kanani, Sandra, Krinsky, Valentine, Pumir, Alain   +2 more
core  

Fruit cell culture as a model system to study cell wall changes during strawberry fruit ripening [PDF]

, 2016
Strawberry (Fragaria x ananassa, Duch.) fruit is characterized by its fast ripening and soft texture at the ripen stage, resulting in a short postharvest shelf life and high economic losses.
Cerezo, Sergio, Matas-Arroyo, Antonio Javier, Mercado, Jose A., Quesada-Felice, Miguel Angel, Ric-Varas, Pablo, Rivera, Juan A.   +5 more
core  

Cell Culturing Station [PDF]

Science, 1975
openaire   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Therapeutic potential and action mechanisms of licochalcone B: a mini review

Frontiers in Molecular Biosciences
Licochalcone B (LicB), a chalcone derived from Glycyrrhiza uralensis and Glycyrrhiza glabra, has received considerable attention due to its diverse pharmacological properties.
Sibhghatulla Shaikh, Sibhghatulla Shaikh, Eun Ju Lee, Eun Ju Lee, Khurshid Ahmad, Khurshid Ahmad, Inho Choi, Inho Choi   +7 more
doaj   +1 more source