Results 221 to 230 of about 11,399,871 (256)

Low-density lipoprotein cholesterol drives multinucleated giant cell formation in response to mycobacterium bovis Bacille Calmette-Guérin. [PDF]

Sci Rep
Merck PA, Lösslein AK, Neuber J, Schwer S, Jonas W, Pospisilik JA, Hilgendorf I, Henneke P, Lohrmann F.   +8 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

An apical ring protein essential for conoid complex assembly and daughter cell formation in Toxoplasma gondii. [PDF]

Nat Commun
Li W, Koczy O, Qin P, Forné I, Gras S, Grünert J, Klingl A, Mattei S, Jimenez-Ruiz E, Meissner M, Meissner M.   +10 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

MLN4924 inhibits macrophage foam cell formation by enhancing autophagy and regulating metabolic phenotype. [PDF]

Lipids Health Dis
Xing L, Bu Y, Shi J, Liu J, Hu F, Zhang M, Fan J.   +6 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Krüppel-like Factor 2 (KLF2) in the Regulation of Lipid Accumulation, ROS, and Mitochondrial Functions During Foam Cell Formation in RAW264.7 Cells. [PDF]

Biology (Basel)
Howlader MSI, Das M, Hansda S, Naidu P, Das H.   +4 more
europepmc   +1 more source

Mitochondrial ROS drive foam cell formation via STAT5 signaling in atherosclerosis. [PDF]

Sci Adv
Boccuni L, Marka F, Salzmann M, Schirripa A, Ableitner E, Siller M, Brekalo M, Haider P, Stojkovic S, Neumayer C, Örd T, Kollmann K, Assinger A, Decker T, Köcher T, Fischer MB, Mußbacher M, Bergthaler A, Hengstenberg C, Podesser BK, Kaikkonen MU, Wojta J, Hohensinner PJ.   +22 more
europepmc   +1 more source

CARMN loss promotes VSMC-derived foam cell formation and atherosclerosis through transcriptional downregulation of autophagy. [PDF]

Cell Death Dis
Huang T, Tang Y, Su Q, Su C, Wang J, Fu L, Tang Y.   +6 more
europepmc   +1 more source