Results 111 to 120 of about 6,470,185 (304)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Condensation of the fusion focus by the intrinsically disordered region of the formin Fus1 is essential for cell-cell fusion

, 2022
Secretory vesicle clusters transported on actin filaments by myosin V motors for local secretion underlie various cellular processes, such as neurotransmitter release at neuronal synapses,(1) hyphal steering in filamentous fungi,(2)(,)(3) and local cell ...
Billault-Chaumartin, I., Billault-Chaumartin, Ingrid, Michon, Laetitia, Martin, Sophie G., Martin, Sophie, Martin, S.G., Michon, L., Muriel, O., Muriel, Olivia, Muriel Lopez, Olivia   +9 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

β1 integrins regulate myoblast fusion and sarcomere assembly [PDF]

, 2003
The mechanisms that regulate the formation of multinucleated muscle fibers from mononucleated myoblasts are not well understood. We show here that extracellular matrix (ECM) receptors of the beta1 integrin family regulate myoblast fusion. beta1-deficient
Dorchies, Olivier M., Ruegg, Urs T., Schwander, Martin, Leu, Marco, Schittny, Johannes, Stumm, Michael, Müller, Ulrich   +6 more
core   +2 more sources

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Two cellular models for analyzing mitochondrial heteroplasmy [PDF]

Exploration of Neuroscience
Aim: Mitochondria are essential for brain development, and the presence of different mitochondrial types is called mitochondrial heteroplasmy. Mitochondrial dysfunction is a central aspect of many people’s neurological diseases.
Yaning Hu, Lin Jiang, Wen Liu, Xingbo Zhao   +3 more
doaj   +1 more source

Computational Mechanism Design for Information Fusion within Sensor Networks

, 2006
Conventional centralised information fusion and control architectures will be challenged by developments in sensor networks that allow sophisticated autonomous sensors, owned by different stakeholders with individual goals, to interact and share ...
S. Reece, N. Jennings, Dash, Rajdeep K, Rogers, Alex, Dash, RK, S. Roberts, Roberts, Stephen, Jennings, N. R., Roberts, S, Rogers, A, Reece, Steve, R. Dash, A. Rogers, Dash, Rajdeep K., Jennings, NR, Reece, S, IEEE   +16 more
core   +1 more source

Deceleration of fusion–fission cycles improves mitochondrial quality control during aging [PDF]

, 2012
Mitochondrial dynamics and mitophagy play a key role in ensuring mitochondrial quality control. Impairment thereof was proposed to be causative to neurodegenerative diseases, diabetes, and cancer.
Michael Meyer-Hermann, Michael Meyer-Hermann (124166), Andreas S. Reichert (124162), Reichert Andreas S., Heinz D. Osiewacz (120841), Figge, Marc Thilo, Reichert, Andreas S, Marc Thilo Figge, Heinz D Osiewacz, Reichert, Andreas, Meyer-Hermann Michael, Meyer-Hermann, Michael (Prof. Dr.), Osiewacz Heinz D., Meyer-Hermann, Michael, Osiewacz, Heinz D., Andreas S Reichert, Figge Marc Thilo, Marc Thilo Figge (155511), Osiewacz, Heinz D   +18 more
core   +2 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

A novel fusogenic herpes simplex virus for oncolytic virotherapy of squamous cell carcinoma

Virology Journal, 2011
Background R849 is a neurovirulent γ134.5 gene-deficient form of herpes simplex virus type 1 (HSV-1) and has LacZ genes at the deleted sites of the γ134.5 gene. HF is a spontaneously occurring, fusogenic HSV-1 strain.
Iwai Soichi, Imai Tomoaki, Ogawa Fumi, Takahashi Gen, Takaoka Hiroo, Yura Yoshiaki   +5 more
doaj   +1 more source