Thermodynamic competition between membrane protein oligomeric states
, 2016 Self-assembly of protein monomers into distinct membrane protein oligomers provides a general mechanism for diversity in the molecular architectures, and resulting biological functions, of membrane proteins.
Haselwandter, Christoph A. +1 more
core +1 more source
The mitochondrial outer membrane
, 2014 Botao Zhang +15 more
openalex +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Gangliosides do not affect ABC transporter function in human neuroblastoma cells
Journal of Lipid Research, 2006 Previous studies have indicated a role for glucosylceramide synthase (GCS) in multidrug resistance (MDR), either related to turnover of ceramide (Cer) or generation of gangliosides, which modulate apoptosis and/or the activity of ABC transporters.
Anne-Jan Dijkhuis +4 more
doaj +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Syndecan-4 negatively regulates antiviral signalling by mediating RIG-I deubiquitination via CYLD
Nature Communications, 2016 Syndecans are transmembrane proteoglycans implicated in diverse cellular activities. Here the authors show that Syndecan-4 via its cytosolic domain negatively regulates antiviral immunity by enhancing RIG-I interaction with a deubiquitinating enzyme CYLD,
Wei Lin +11 more
doaj +1 more source
, 2012 Signals recorded from neurons with extracellular planar sensors have a wide range of waveforms and amplitudes. This variety is a result of different physical conditions affecting the ion currents through a cellular membrane.
A Lambacher +35 more
core +1 more source
Pathogenic mechanisms in the rheumatoid nodule: Comparison of proinflammatory cytokine production and cell adhesion molecule expression in rheumatoid nodules and synovial membranes from the same patient [PDF]
, 1998 R. Wikaningrum +7 more
openalex +1 more source
Influence of temperature and nitrogen pressure on the test without active gases for high-temperature proton exchange membrane fuel cells [PDF]
, 2023 Wojciech Aleksander Rosiński +2 more
openalex +1 more source