Results 111 to 120 of about 3,609,152 (355)
Thermodynamic competition between membrane protein oligomeric states
, 2016 Self-assembly of protein monomers into distinct membrane protein oligomers provides a general mechanism for diversity in the molecular architectures, and resulting biological functions, of membrane proteins.
Haselwandter, Christoph A. +1 more
core +1 more source
Molecular Oncology, EarlyView.B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez +17 more
wiley +1 more source
The effect of redox dyes on the active transport of hydrogen, potassium and sodium ions across the yeast cell membrane [PDF]
, 1955 E. J. Conway, R. P. Kernan
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, 2018 Lipid phase heterogeneity in the plasma membrane is thought to be crucial for many aspects of cell signaling, but the physical basis of participating membrane domains such as "lipid rafts" remains controversial.
Baird, Barbara +4 more
core +1 more source
Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
Syndecan-4 negatively regulates antiviral signalling by mediating RIG-I deubiquitination via CYLD
Nature Communications, 2016 Syndecans are transmembrane proteoglycans implicated in diverse cellular activities. Here the authors show that Syndecan-4 via its cytosolic domain negatively regulates antiviral immunity by enhancing RIG-I interaction with a deubiquitinating enzyme CYLD,
Wei Lin +11 more
doaj +1 more source
EVIDENCE OF ACTIVE TRANSFER OF CERTAIN NON-ELECTROLYTES ACROSS THE HUMAN RED CELL MEMBRANE [PDF]
, 1948 Paul G. LeFevre
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Molecular Oncology, EarlyView.Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen +12 more
wiley +1 more source
Gangliosides do not affect ABC transporter function in human neuroblastoma cells
Journal of Lipid Research, 2006 Previous studies have indicated a role for glucosylceramide synthase (GCS) in multidrug resistance (MDR), either related to turnover of ceramide (Cer) or generation of gangliosides, which modulate apoptosis and/or the activity of ABC transporters.
Anne-Jan Dijkhuis +4 more
doaj +1 more source
SEMIPERMEABILITY OF THE NUCLEAR MEMBRANE IN THE INTACT CELL [PDF]
, 1959 Clifford V. Harding, Carl M. Feldherr
openalex +1 more source