Results 171 to 180 of about 2,511,430 (316)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Advancements in Cell Membrane-Derived Biomimetic Nanotherapeutics for Breast Cancer. [PDF]

Int J Nanomedicine
Zeng M, Hu C, Chen T, Zhao T, Dai X.
europepmc   +1 more source

Ionic Relations of Cells of Chara Australis IX. Analysis of Transient Membrane Currents

, 1964
GP Findlay, AB Hope
openalex   +1 more source

Is the Cell Membrane a Universal Rate-Limiting Barrier to the Movement of Water between the Living Cell and Its Surrounding Medium? [PDF]

, 1967
Gilbert N. Ling, Margaret M. Ochsenfeld, George Karreman   +2 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Study on the Effect of the Envelope of Terahertz Unipolar Stimulation on Cell Membrane Communication-Related Variables. [PDF]

Research (Wash D C)
Bo W, Che R, Jia F, Sun K, Liu Q, Guo L, Zhang X, Gong Y.   +7 more
europepmc   +1 more source

On the Membrane of the Tannin Vacuole in the Mimosa Motor Cell

, 1968
Hideo Toriyama, Syôiti Satô
openalex   +2 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Bacterial cell membrane models: choosing the lipid composition.

Soft Matter
Martin AL, Jemmett PN, Howitt T, Wood MH, Cox LR, Dafforn TR, Campana M, Welbourn RJL, Skoda MWA, Clifton LA, Hussain H, Rawle JL, Carlà F, Nicklin CL, Arnold T, Horswell SL.   +15 more
europepmc   +1 more source

Natural killer cell membrane manipulation for augmented immune synapse and anticancer efficacy. [PDF]

Mater Today Bio
Ryu M, Kim E, Kim S, Kim K.
europepmc   +1 more source