Results 171 to 180 of about 4,055,008 (348)

Effect of solanine on the membrane potential of mitochondria in HepG₂cells and [Ca²⁺]_iin the cells

, 2006
Shiyong Gao
openalex   +2 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Conformational Dynamics in the Cell Membrane Interactions of Bispecific Targeted Degrader Therapeutics. [PDF]

J Med Chem
Inganäs E, Lavén H, Caraballo R, Klingegård F, Eklund M, Andersson L, Hilgendorf C, Matsson P.   +7 more
europepmc   +1 more source

​Plasma Membrane (Cell Membrane) [PDF]

, 2019
openaire   +1 more source

Failure Mode and Effect Analysis, and Fault Tree Analysis of Polymer Electrolyte Membrane Fuel Cells

, 2015
Michael Whiteley, Sarah Dunnett, Lisa Jackson   +2 more
openalex   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Advances in the multifunctionality of cell membrane-encapsulated nanoparticles in the treatment of colorectal cancer. [PDF]

Front Immunol
Qiu Z, Liu W, Xu S.
europepmc   +1 more source

Study of the acetonitrile poisoning of platinum cathodes on proton exchange membrane fuel cell spatial performance using a segmented cell system

, 2015
Tatyana V. Reshetenko, Jean St‐Pierre
openalex   +2 more sources

Both Membrane Depolarization And IL-6 Induce Calcium-Dependent Hsp70 Expression In Skeletal Muscle Cells [PDF]

, 2009
Gonzalo Jorquera, Nevenka Juretić, Alejandra Espinosa, Enrique Jaimovich, Nora Riveros   +4 more
openalex   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source