Results 171 to 180 of about 4,820,053 (311)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Sexual dimorphism in the cell number of the adult Drosophila brain. [PDF]

PLoS One
Singh NP, Harbison ST.
europepmc   +1 more source

LAT1 expression influences Paneth cell number and tumor development in Apc^Min/+ mice. [PDF]

J Gastroenterol, 2023
Sui Y, Hoshi N, Ohgaki R, Kong L, Yoshida R, Okamoto N, Kinoshita M, Miyazaki H, Ku Y, Tokunaga E, Ito Y, Watanabe D, Ooi M, Shinohara M, Sasaki K, Zen Y, Kotani T, Matozaki T, Tian Z, Kanai Y, Kodama Y.   +20 more
europepmc   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Sex- and Male-Morph-Specific Variation in Brain Mass and Cell Number Scaling in Solitary Centris pallida (Hymenoptera: Apidae) Bees. [PDF]

J Comp Neurol
Barrett M, Godfrey RK.
europepmc   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

The role of mitochondrial DNA in tumorigenesis [PDF]

Mitochondria are cytoplasmic organelles that are found in almost all mammalian cells. Mitochondria contain their own genome, mitochondrial DNA (mtDNA) that encodes 13 subunits of the electron transfer chain, which is the primary generator of cellular ...
Dickinson, Adam
core  

Haematopoietic stem cell number is not solely defined by niche availability. [PDF]

Nature
Takeishi S, Marchand T, Koba WR, Borger DK, Xu C, Guha C, Bergman A, Frenette PS, Gritsman K, Steidl U.   +9 more
europepmc   +1 more source

Apical-basal polarity precisely determines intestinal stem cell number by regulating Prospero threshold. [PDF]

Cell Rep, 2023
Wu S, Yang Y, Tang R, Zhang S, Qin P, Lin R, Rafel N, Lucchetta EM, Ohlstein B, Guo Z.   +9 more
europepmc   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source