Results 261 to 270 of about 23,513,766 (356)

Smaug regulates germ plasm assembly and primordial germ cell number in Drosophila embryos. [PDF]

Sci Adv
Siddiqui NU, Karaiskakis A, Goldman AL, Eagle WVI, Low TCH, Luo H, Smibert CA, Gavis ER, Lipshitz HD.   +8 more
europepmc   +1 more source

Effects of Continuous Moderate Intensity Training (MICT) and Intermittent Calorie Restriction on Changes in Blood Sugar Levels and The Number of Pancreatic Beta Cells of Female Mice Pancreas (Mus Musculus) on A High Glycemic Index Diet [PDF]

Belia Nurmaulida Anindito Putri, Hayuris Kinandita Setiawan, Rimbun Rimbun, Ira Humairah, Amin Ismail   +4 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Discovery of Cell Number-Interstitial Fluid Volume (CIF) Ratio Reveals Secretory Autophagy Pathway to Supply eHsp90α for Wound Healing. [PDF]

Cells
Chang C, Tang X, Schönthal AH, Chen M, Woodley DT, Wang Y, Liang C, Li W.   +7 more
europepmc   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Loss of TET2 increases B-1 cell number and IgM production while limiting CDR3 diversity. [PDF]

Front Immunol
Dennis E, Murach M, Blackburn CMR, Marshall M, Root K, Pattarabanjird T, Deroissart J, Erickson LD, Binder CJ, Bekiranov S, McNamara CA.   +10 more
europepmc   +1 more source

Factors Affecting Mammary Gland Cell Numbers

Journal of Dairy Science, 1969
openaire   +2 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

GLP-1R signaling modulates colonic energy metabolism, goblet cell number and survival in the absence of gut microbiota. [PDF]

Mol Metab
Greiner TU, Koh A, Peris E, Bergentall M, Johansson MEV, Hansson GC, Drucker DJ, Bäckhed F.   +7 more
europepmc   +1 more source

T Cell Activation Induces Rapid Tyrosine Phosphorylation of a Limited Number of Cellular Substrates

, 1989
Eric D. Hsi, Jeffrey Siegel, Yasuhiro Minami, E T Luong, Richard D. Klausner, Lawrence E. Samelson   +5 more
openalex   +1 more source