Results 81 to 90 of about 20,297,709 (266)

Identifiability and privacy in pluripotent stem cell research [PDF]

, 2014
Data sharing is an essential element of research; however, recent scientific and social developments have challenged conventional methods for protecting privacy.
Williams, C, Bredenoord, AL, Rooke, Heather, Isasi, R;Andrews, PW;Baltz, JM;Bredenoord, AL;Burton, P;Chiu, IM;Hull, SC;Jung, JW;Kurtz, A;Lomax, G;Ludwig, T;McDonald, M;Morris, C;Ng, HH;Rooke, H;Sharma, A;Stacey, GN;Williams, C;Zeng, F;Knoppers, BM, Baltz, Jay M, Sharma, A, Zeng, F, Ludwig, Tenneille, Kurtz, A, Morris, Clive, Ng, HH, Isasi, Rosario, McDonald, M, Kurtz, Andreas, Burton, P, Zeng, Fanyi, Chiu, Ing-Ming, Andrews, Peter W, Morris, C, Jung, J-W, Lomax, Geoffrey, Burton, Paul, Lomax, G, Sharma, Alka, Hull, SC, Chiu, I-M, Bredenoord, Annelien L, Andrews, PW, Stacey, GN, McDonald, Michael, Stacey, Glyn N, Jung, Ji-Won, Ludwig, T, Rooke, H, Knoppers, BM, Williams, Clare, Isasi, R, Baltz, JM, Baltz, Jay M., Andrews, Peter W., Ng, Huck Hui, Stacey, Glyn N., Bredenoord, Annelien L., Knoppers, Bartha Maria, Hull, Sara Chandros   +44 more
core   +1 more source

Limitations and possibilities of low cell number ChIP-seq

BMC Genomics, 2012
Background Chromatin immunoprecipitation coupled with high-throughput DNA sequencing (ChIP-seq) offers high resolution, genome-wide analysis of DNA-protein interactions. However, current standard methods require abundant starting material in the range of
Gilfillan Gregor D, Hughes Timothy, Sheng Ying, Hjorthaug Hanne S, Straub Tobias, Gervin Kristina, Harris Jennifer R, Undlien Dag E, Lyle Robert   +8 more
doaj   +1 more source

Abatacept for Prophylaxis of Acute and Chronic Graft‐Versus‐Host‐Disease in Children Undergoing Allogeneic Hematopoietic Stem Cell Transplantation—A Systematic Review and Meta‐Analysis of Cohort Studies

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Graft‐versus‐host disease (GvHD) remains one of the most significant complications of hematopoietic stem cell transplantation (HSCT). Abatacept, a selective T‐cell costimulation modulator, is a relatively novel prophylactic agent, though pediatric data remain limited.
Matthijs D. Kruizinga, Anne B. Verbeek, Caroline A. Lindemans, Emilie P. Buddingh   +3 more
wiley   +1 more source

Nonmyelinating Schwann Cells Maintain Hematopoietic Stem Cell Hibernation in the Bone Marrow Niche

, 2011
SummaryHematopoietic stem cells (HSCs) reside and self-renew in the bone marrow (BM) niche. Overall, the signaling that regulates stem cell dormancy in the HSC niche remains controversial.
Iwama, Atsushi, Nakauchi, Hiromitsu, Miyoshi, Hiroyuki, Satoshi Yamazaki, Stefan Karlsson, Karlsson, Göran, Atsushi Iwama, Hideo Ema, Karlsson, Göran,, Shioda, Seiji, Göran Karlsson, Karlsson, Stefan, Tomoyuki Yamaguchi, Hiroyuki Miyoshi, Hiromitsu Nakauchi, Ema, Hideo, Karlsson, Stefan,, Yamaguchi, Tomoyuki, Seiji Shioda, Yamazaki, Satoshi, Makoto M. Taketo, Lund University., Taketo, Makoto M.   +22 more
core   +1 more source

Bone and Soft Tissue Neoplasms in Infants Versus Older Children: A Report From the Cancer in Young People in Canada Program

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Infant bone and soft tissue neoplasms present distinct clinical challenges and lack large‐scale data to inform treatment decisions. This study aims to characterize bone and soft tissue neoplasms in infants in Canada and to compare their outcomes with those of older pediatric patients.
Samuel Sassine, Hallie Coltin, Maria Kondyli, Monia Marzouki, Nicolas Prud'homme, Nida Usmani, Rebecca J. Deyell, Lesleigh Abbott, Tony H. Truong, Sapna Oberoi, Ketan Kulkarni, Josée Brossard, Lynette Bowes, Paul Gibson, Sarah McKillop, Roona Sinha, Lillian Sung, Catherine Vezina, Laura Wheaton, Alexandra P. Zorzi, Marie‐Claude Pelland‐Marcotte, Thai Hoa Tran   +21 more
wiley   +1 more source

cMyc increases cell number through uncoupling of cell division from cell size in CHO cells

BMC Biotechnology, 2009
Background Over the past decades, the increase in maximal cell numbers for the production of mammalian derived biologics has been in a large part due to the development of optimal feeding strategies.
Kuystermans Darrin, Al-Rubeai Mohamed
doaj   +1 more source

Feeding, Fear, and Acceptance: Caregivers’ Experiences of Nutritional Support During Childhood Cancer Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose To explore caregivers' experiences and perceptions of the nutritional challenges faced by children and adolescents undergoing cancer treatment, including oral intake and the use of nutritional support. Methods This was a qualitative study based on focus groups with parents and caregivers at a Brazilian pediatric oncology hospital ...
Danyelle Apparecida Balsamão Marques, Mariana dos Santos Murra, Welinton Hirai, Ana Laura Balduino do Nascimento, Karla Emilia de Sá Rodrigues, Wilson Elias de Oliveira Junior   +5 more
wiley   +1 more source

Neurocognitive, School‐Based, and Quality of Life Outcomes for Youth With Sickle Cell Disease and Thalassemia: A Scoping Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT The medical burdens of sickle cell disease (SCD) and transfusion‐dependent β‐thalassemia (TDT) are chronic and cumulative, even in children. Yet the effects expand beyond medications and healthcare visits due to their impacts on school attendance, academic performance, and peer engagement.
Mary Ann Etling, Hakim Tokhi, Alexander A. Boucher   +2 more
wiley   +1 more source

Representation of Sickle Cell Disease Patients in Pediatric and Adult Care: What We Discovered Using Informatics for Integrating Biology and the Bedside (i2b2) Data

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Transitioning from pediatric to adult care is a high‐risk period for individuals with sickle cell disease (SCD). An initial observation at one academic medical center suggested a sex‐based disparity in clinic populations, prompting a national investigation.
Laurie J. Duckworth, Kholod Alhassan, Ada De La Osa, John Stephen, Yue Yao, Diana J. Wilkie   +5 more
wiley   +1 more source

c-Myb and p300 regulate hematopoietic stem cell proliferation and differentiation.

, 2005
Precise control of hematopoietic stem cell (HSC) proliferation and differentiation is needed to maintain a lifetime supply of blood cells. Using genome-wide ENU mutagenesis and phenotypic screening, we have identified a mouse line that harbors a point ...
Sandberg, Mark, Wiltshire, Timothy, Tarantino, Lisa, Hogenesch, John, Pletcher, Mathew, Cooke, Michael, Sutton, Susan, Mark L. Sandberg, Susan E. Sutton, John B. Hogenesch, Mathew T. Pletcher, Lisa M. Tarantino, Michael P. Cooke, Tim Wiltshire   +13 more
core   +1 more source