Results 1 to 10 of about 123,072 (25)
Polarized interfacial tension induces collective migration of cells, as a cluster, in a three-dimensional tissue [PDF]
, 2021 Cells collectively migrate as a cluster in three-dimensional (3D) tissues, such as in embryogenesis and cancer invasion. Here, numerical simulations using a 3D vertex model show that polarized interfacial tension, expressing cell adhesion and cortex contractility, induces the cluster migration in the 3D space.
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Shape-velocity correlation defines polarization in migrating cell simulations [PDF]
, 2021 Cell migration plays essential roles in development, wound healing, diseases, and in the maintenance of a complex body. Experiments in collective cell migration generally measure quantities such as cell displacement and velocity. The observed short-time diffusion regime for mean square displacement in single-cell migration experiments on flat surfaces ...
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Emergence of collective propulsion through cell-cell adhesion [PDF]
Phys. Rev. E 97, 042413 (2018), 2017 The mechanisms driving the collective movement of cells remain poorly understood. To contribute toward resolving this mystery, a model was formulated to theoretically explore the possible functions of polarized cell-cell adhesion in collective cell migration. The model consists of an amoeba cell with polarized cell-cell adhesion, which is controlled by
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A cell membrane model that reproduces cortical flow-driven cell migration and collective movement [PDF]
, 2023 Many fundamental biological processes are dependent on cellular migration. Although the mechanical mechanisms of single-cell migration are relatively well understood, those underlying migration of multiple cells adhered to each other in a cluster, referred to as cluster migration, are poorly understood.
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One dimensional cell motility patterns [PDF]
Phys. Rev. Research 2, 033237 (2020), 2020 During migration cells exhibit a rich variety of seemingly random migration patterns, which makes unraveling the underlying mechanisms that control cell migration a daunting challenge. For efficient migration cells require a mechanism for polarization, so that traction forces are produced in the direction of motion, while adhesion is released to allow ...
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A minimal model for spontaneous cell polarization and edge activity in oscillating, rotating and migrating cells [PDF]
Nature Physics 12 2016 367, 2016 How the cells break symmetry and organize their edge activity to move directionally is a fun- damental question in cell biology. Physical models of cell motility commonly rely on gradients of regulatory factors and/or feedback from the motion itself to describe polarization of edge activity.
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Collective Alignment of Cells in Planar Cell Polarity: Insights from a Spin Model [PDF]
arXiv, 2023 In metazoans, cells collectively polarize and align along the tissue plane. This phenomenon is called Planar cell polarity (PCP). Polarization means asymmetric segregation of molecules and sub-cellular structures within a cell. In PCP, cells collectively align in a particular direction along the tissue plane through identical polarization.
arxiv
Effects of 3D Geometries on Cellular Gradient Sensing and Polarization [PDF]
Phys. Biol. 13 036008 (2016), 2015 During cell migration, cells become polarized, change their shape, and move in response to various internal and external cues. Cell polarization is defined through the spatio-temporal organization of molecules such as PI3K or small GTPases, and is determined by intracellular signaling networks.
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Cell Motion Alignment as Polarity Memory Effect [PDF]
, 2019 The clarification of the motion alignment mechanism in collective cell migration is an important issue commonly in physics and biology. In analogy with the self-propelled disk, the polarity memory effect of eukaryotic cell is a fundamental candidate for this alignment mechanism.
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Polarization resolved angular patterns in nematic liquid crystal cells [PDF]
J. Phys. : Condens. Matter 19, 246102 (2007), 2006 We study the angular structure of polarization of light transmitted through a nematic liquid crystal (NLC) cell by theoretically analyzing the polarization state as a function of the incidence angles. For a uniformly aligned NLC cell, the $4\times 4$ matrix formalism and the orthogonality relations are used to derive the analytical expressions for the ...
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