Results 1 to 10 of about 441,288 (205)

Establishing cell polarity in plants: the role of cytoskeletal structures and regulatory pathways [PDF]

Frontiers in Cell and Developmental Biology
Cell polarity is a fundamental mechanism of plant cells that drives cellular specialization and the formation of diverse cell types. It regulates critical developmental events, including polarized tip growth (such as pollen tubes and root hairs ...
Chao Ma, Jianbin Chang, Olivia S. Hazelwood, M. Arif Ashraf, Qiong Nan   +4 more
doaj   +3 more sources

Arabidopsis  SABRE and CLASP interact to stabilize cell division plane orientation and planar polarity [PDF]

, 2013
The orientation of cell division and the coordination of cell polarity within the plane of the tissue layer (planar polarity) contribute to shape diverse multicellular organisms. The root of Arabidopsis thaliana displays regularly oriented cell divisions,
Alonso, J.M., Grebe, M., Gustavsson, A., Hörstedt, P., Ikeda, Y., Kalmbach, L., Kiefer, C., Pietra, S., Stepanova, A.N.   +8 more
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Quantification of nematic cell polarity in three-dimensional tissues. [PDF]

PLoS Computational Biology, 2020
How epithelial cells coordinate their polarity to form functional tissues is an open question in cell biology. Here, we characterize a unique type of polarity found in liver tissue, nematic cell polarity, which is different from vectorial cell polarity ...
André Scholich, Simon Syga, Hernán Morales-Navarrete, Fabián Segovia-Miranda, Hidenori Nonaka, Kirstin Meyer, Walter de Back, Lutz Brusch, Yannis Kalaidzidis, Marino Zerial, Frank Jülicher, Benjamin M Friedrich   +11 more
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aPKC: the Kinase that Phosphorylates Cell Polarity [version 1; referees: 2 approved] [PDF]

F1000Research, 2018
Establishing and maintaining cell polarity are dynamic processes that necessitate complicated but highly regulated protein interactions. Phosphorylation is a powerful mechanism for cells to control the function and subcellular localization of a target ...
Yang Hong
doaj   +2 more sources

ZO-2/Tjp2 suppresses Yap and Wwtr1/Taz-mediated hepatocyte to cholangiocyte transdifferentiation in the mouse liver

npj Regenerative Medicine, 2022
TJP2/ZO-2-inactivating mutations in humans cause progressive cholestatic liver disease. Liver-specific deletion of Tjp2 in the mouse (Tjp2 cKO mice) leads to mild progressive cholestasis without an overt degradation of the bile-blood barrier (BBB). These
Jianliang Xu, P. Jaya Kausalya, Alicia Ghia Min Ong, Christine Meng Fan Goh, Safiah Mohamed Ali, Walter Hunziker   +5 more
doaj   +1 more source

Cell Adhesion at the Tight Junctions: New Aspects and New Functions

Cells, 2023
Tight junctions (TJ) are cell–cell adhesive structures that define the permeability of barrier-forming epithelia and endothelia. In contrast to this seemingly static function, TJs display a surprisingly high molecular complexity and unexpected dynamic ...
Nicolina Wibbe, Klaus Ebnet
doaj   +1 more source

The mitochondrial outer membrane protein SYNJ2BP interacts with the cell adhesion molecule TMIGD1 and can recruit it to mitochondria

BMC Molecular and Cell Biology, 2020
Background Transmembrane and immunoglobulin domain-containing protein 1 (TMIGD1) is a recently identified cell adhesion molecule which is predominantly expressed by epithelial cells of the intestine and the kidney. Its expression is downregulated in both
Christian Hartmann, Ysabel Alessa Schwietzer, Daniel Kummer, Nils Kirschnick, Esther Hoppe, Eva-Maria Thüring, Mark Glaesner-Ebnet, Frauke Brinkmann, Volker Gerke, Stefan Reuter, Masanori Nakayama, Klaus Ebnet   +11 more
doaj   +1 more source

Intermediate Filaments from Tissue Integrity to Single Molecule Mechanics

Cells, 2021
Cytoplasmic intermediate filaments (IFs), which together with actin and microtubules form the cytoskeleton, are composed of a large and diverse family of proteins.
Emma J. van Bodegraven, Sandrine Etienne-Manneville   +1 more
doaj   +1 more source

Loss of contact inhibition of locomotion in the absence of JAM-A promotes entotic cell engulfment

iScience, 2022
Summary: Entosis is a cell competition process during which tumor cells engulf other tumor cells. It is initiated by metabolic stress or by loss of matrix adhesion, and it provides the winning cell with resources derived from the internalized cell. Using
Mariel F. Schwietzer, Sonja Thölmann, Daniel Kummer, Anne Kaschler, Lilo Greune, Eva-Maria Thüring, M. Alexander Schmidt, Volker Gerke, Klaus Ebnet   +8 more
doaj   +1 more source

PTEN inhibits AMPK to control collective migration

Nature Communications, 2022
Pten is a tumour suppressor gene that is associated with highly invasive cancers such as glioblastoma. Here the authors show that PTEN loss results in increased migratory behaviour, which can be countered by targeting AMPK activity.
Florent Peglion, Lavinia Capuana, Isabelle Perfettini, Laurent Boucontet, Ben Braithwaite, Emma Colucci-Guyon, Emie Quissac, Karin Forsberg-Nilsson, Flora Llense, Sandrine Etienne-Manneville   +9 more
doaj   +1 more source