Results 111 to 120 of about 2,032,190 (314)

Molecular and epistatic interactions between pioneer transcription factors shape nucleosome dynamics and cell differentiation

Nature Communications
Pioneer transcription factors (TF) bind nucleosome-embedded DNA motifs to activate new regulatory elements and promote differentiation. However, the complexity, binding dependencies and temporal effects of their action remain unclear.
Rémi-Xavier Coux, Agnès Dubois, Almira Chervova, Inma Gonzalez, Sandrine Vandormael-Pournin, Michel Cohen-Tannoudji, Pablo Navarro   +6 more
doaj   +1 more source

Enhanced Proapoptotic Effects of Water Dispersed Complexes of 4-Thiazolidinone-Based Chemotherapeutics with a PEG-Containing Polymeric Nanocarrier

Nanoscale Research Letters, 2019
Aim To study whether water formulation of the complex of 4-thiazolidinone derivatives with a PEG-containing polymeric nanocarrier enhances their pro-apoptotic action towards rat glioma C6 cells.
L. Kobylinska, I. Ivasechko, N. Skorokhyd, R. Panchuk, A. Riabtseva, N. Mitina, A. Zaichenko, R. Lesyk, B. Zimenkovsky, R. Stoika, S. G. Vari   +10 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

A redox switch in p21-CDK feedback during G2 phase controls the proliferation-cell cycle exit decision. [PDF]

Reactive oxygen species (ROS) influence cell proliferation and fate decisions by oxidizing cysteine residues (S-sulfenylation) of proteins, but specific targets and underlying regulatory mechanisms remain poorly defined.
Coupe, D, Yu, L, Böhlig, K, Zerjatke, T, Mansfeld, J, Vorhauser, J, Glauche, I, Choudhary, JS, Roumeliotis, TI, Leung, JK, Nadler, A   +10 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Effect of p21Waf1 and p27Kip1 on centrosome replication and proliferation of breast cancer cell [PDF]

, 2010
Aberrant centrosome numbers are detected in virtually all cancers，increasing the risk for cell division errors and chromosomal instability.
Yin-Lin Ge, Dan-Dan Jiang, Fu-Nian Li, Ming-Zhi Cao, Xiang-Ping Liu, Xin-Gang Wang   +5 more
core   +1 more source

A characterization of four B16 murine melanoma cell sublines molecular fingerprint and proliferation behavior [PDF]

, 2013
Background: One of the most popular and versatile model of murine melanoma is by inoculating B16 cells in the syngeneic C57BL6J mouse strain. A characterization of different B16 modified cell sub-lines will be of real practical interest.
Radeke, Heinfried H., Cristina Dehelean, Pînzaru, Simona Cîntă, Dehelean, Cristina, Melania F Munteanu, Barbu-Tudoran, Lucian, Alexandra Falamas, Danciu, Corina, Codruta Soica, Falamas, Alexandra, Corina Danciu, Simona Pînzaru, Florina Bojin, Munteanu, Melania F., Heinfried Radeke, Lucian Barbu-Tudoran, Soica, Codruţa, Bojin, Florina   +17 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Stochastic mathematical models of cell proliferation assays [PDF]

, 2017
Cell proliferation assays are routinely used to study collective cell behaviour, and can be interpreted with mathematical models. In this thesis, we apply a computational Bayesian technique to calibrate stochastic discrete mathematical models of cell ...
Browning, Alexander P.
core   +1 more source

TLR7/8 signaling activation enhances the potency of human pluripotent stem cell-derived eosinophils in cancer immunotherapy for solid tumors

Experimental Hematology & Oncology
Background Efficient tumor T-cell infiltration is crucial for the effectiveness of T-cell-based therapies against solid tumors. Eosinophils play crucial roles in recruiting T cells in solid tumors.
Sheng Zhu, Zhengyang Zhou, Ruixin Gu, Zixin Zhao, Yingfeng Zhang, Yudi Miao, Qi Lei, Tianxing Liu, Guokai Wang, Chenyi Dai, Yi Huo, Jinghao You, Lejun Lv, Cheng Li, Ming Yin, Chengyan Wang, Hongkui Deng   +16 more
doaj   +1 more source