Results 201 to 210 of about 15,022,196 (353)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Cyanide is an endogenous stimulator of endothelial cell proliferation, migration and differentiation. [PDF]

Exp Biol Med (Maywood)
Kieronska-Rudek A, Petrosino M, Zuhra K, Szabo C.   +3 more
europepmc   +1 more source

Interrupted Glucagon Signaling Reveals Hepatic α Cell Axis and Role for L-Glutamine in α Cell Proliferation.

Cell Metabolism, 2017
E. D. Dean, Mingyu Li, Mingyu Li, Nripesh Prasad, S. Wisniewski, Alison Von Deylen, Jason M. Spaeth, Lisette A Maddison, Anthony Botros, Leslie R. Sedgeman, N. Bozadjieva, O. Ilkayeva, Anastasia Coldren, Greg Poffenberger, Alena Shostak, Michael C Semich, Kristie I. Aamodt, Neil Phillips, Hai Yan, E. Bernal-Mizrachi, J. Corbin, K. Vickers, S. Levy, C. Dai, C. Newgard, W. Gu, R. Stein, Wenbiao Chen, A. Powers   +28 more
semanticscholar   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Expression of Bruton's Tyrosine Kinase Reflects Immune Cells Infiltration and Cell Proliferation in Breast Cancer. [PDF]

World J Oncol
AlRammah T, Wu R, Chida K, Kawashima K, Hakamada K, Ishikawa T, Ebos JML, Takabe K.   +7 more
europepmc   +1 more source

bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila.

Cell, 2003
J. Brennecke, D. Hipfner, A. Stark, R. Russell, S. Cohen   +4 more
semanticscholar   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

PDIA6 promotes the cell proliferation of ESCC by enhancing the disulfide bond formation in TRAF4. [PDF]

Cell Mol Biol Lett
Chen Y, Zhang W, Chen Y, Li X, Shi Y, Yuan Q, Han R, Zhang Y, Zhao X, Hu Y, Zhang C, Dong Z, Lee MH, Kim MO, Dong Z, Jiang Y, Liu K.   +16 more
europepmc   +1 more source

Measurement of cell proliferation

Gastroenterology, 1984
R A, Goodlad, N A, Wright
openaire   +2 more sources

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source