Results 201 to 210 of about 6,520,444 (304)

High frequency acoustic cell stimulation promotes exosome generation regulated by a calcium-dependent mechanism. [PDF]

Commun Biol, 2020
Ambattu LA, Ramesan S, Dekiwadia C, Hanssen E, Li H, Yeo LY.   +5 more
europepmc   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Biomimetic cell stimulation with a graphene oxide antigen-presenting platform for developing T cell-based therapies. [PDF]

Nat Nanotechnol
Zhu E, Yu J, Li YR, Ma F, Wang YC, Liu Y, Li M, Kim YJ, Zhu Y, Hahn Z, Zhou Y, Brown J, Zhang Y, Pelegrini M, Hsiai T, Yang L, Huang Y.   +16 more
europepmc   +1 more source

T cell stimulation and expansion by SunTag-based clustering of anti-CD3/CD28 scFv. [PDF]

Aging (Albany NY), 2020
Zhong K, Liu Z, Li H, Zhao S, Wang Y, Guo W, Zheng X, Yang H, Guo G, Zhou L, Xu J, Tong A.   +11 more
europepmc   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Dose-response studies of methylated and nonmethylated CpG ODNs from <i>Bifidobacterium</i> longum subsp. <i>infantis</i> for optimizing Treg cell stimulation. [PDF]

Allergy Asthma Proc
Li D, Cruz I, Sorkhabi S, Foley PL, Wagner J, Bellanti JA.   +5 more
europepmc   +1 more source

Patients' NK cell stimulation with activated plasmacytoid dendritic cells increases dinutuximab-induced neuroblastoma killing. [PDF]

Cancer Immunol Immunother, 2020
Belounis A, Ayoub M, Cordeiro P, Lemieux W, Teira P, Haddad E, Herblot S, Duval M.   +7 more
europepmc   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Reply to: Editorial "The increasing use of T-cell stimulation for successful dengue vaccination" in eBioMedicine 2024; 102, 105120. DOI: https://doi.org/10.1016/j.ebiom.2024.105120. [PDF]

EBioMedicine
Kandeil W, Nascimento E, Tricou V, Sharma M, Wallace D.   +4 more
europepmc   +1 more source