Results 91 to 100 of about 406,501 (295)

Charge environments around phosphorylation sites in proteins [PDF]

, 2008
Background: Phosphorylation is a central feature in many biological processes. Structural analyses have identified the importance of charge-charge interactions, for example mediating phosphorylation-driven allosteric change and protein binding to ...
Kitchen, James, Rebecca E Saunders, Jim Warwicker, Saunders, Rebecca E., Warwicker, Jim, Warwicker, Jim; id_orcid, James Kitchen   +6 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Biophysical investigation of bacterial aggregation [PDF]

, 2008
In nature, bacteria usually exist as aggregates, in order to withstand changes in environmental conditions. Bacterial aggregation is of great significance in the field of biotechnology, environmental studies and medicine.
Eboigbodin, Kevin Efosa
core  

Charge carrier separation induced by intrinsic surface strain in pristine ZnO nanowires

, 2010
We predict by first-principles calculations a spontaneous charge carrier separation mechanism in pristine [0001]-oriented ZnO nanowires. We find that the shrinking strain induced by surface reconstruction causes electrons and holes to separate and move ...
Li, Chun, Chen, Changfeng, Chun Li, Zi-Yue Zhang, Changfeng Chen, Guo, Wanlin, Liangzhi Kou, Kou, Liangzhi, Zhang, Zi-Yue, Wanlin Guo   +9 more
core   +1 more source

Human cord blood derived immature basophils show dual characteristics, expressing both basophil and eosinophil associated proteins [PDF]

, 2012
Basophils are blood cells of low abundance associated with allergy, inflammation and parasite infections. To study the transcriptome of mature circulating basophils cells were purified from buffy coats by density gradient centrifugations and two-step ...
Grundström Jeanette, Grundström, Jeanette, Reimer, JM, Sofia E Magnusson, Sofia E. Magnusson, Nilsson, Gunnar, Hellman, L, Wernersson, Sara, Wernersson, S, Magnusson, SE, Wernersson, Sara,, Nilsson Gunnar, Reimer Jenny M., Sara Wernersson, Grundström, Jeanette,, Jenny M. Reimer, Hellman, Lars,, Hellman, Lars, Wernersson Sara, Jenny M Reimer, Gunnar Nilsson, Nilsson, G,, Lars Hellman, Jeanette Grundström, Magnusson Sofia E., Magnusson, Sofia E., Grundstrom, J, Reimer, Jenny M., Reimer, Jenny M.,, Hellman Lars   +29 more
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Direct dilution of cell aliquot for high temporal resolution bacteria cell surface charge measurement

, 2016
Bacteria surface charge mediates important cell-environment and microbe-host interactions, and its accurate and precise measurement by microelectrophoresis requires removing metabolites adhered to the cell surface - where repeated centrifugation and ...
Yen-Peng Ting, Wenfa Ng
core   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Introduction of lactobionic acid ligand into mixed-charge nanoparticles to realize in situ triggered active targeting to hepatoma cells

Materials Today Bio, 2019
To overcome the dilemma between passive tissue targeting and active cell targeting, nanomaterials are often required to exhibit the transition from ‘stealth’ to ‘active targetable’ in response to the pathological microenvironment.
H. Li, X. Li, Y. Wang, J. Ji
doaj   +1 more source

Quantifying the evolution of atomic interaction of a complex surface with a functionalized atomic force microscopy tip

Scientific Reports, 2020
Terminating the tip of an atomic force microscope with a CO molecule allows data to be acquired with a well-known and inert apex. Previous studies have shown conflicting results regarding the electrostatic interaction, indicating in some cases that the ...
Alexander Liebig, Prokop Hapala, Alfred J. Weymouth, Franz J. Giessibl   +3 more
doaj   +1 more source