Results 91 to 100 of about 564,510 (265)

Combinatorial functions of two chimeric antibodies directed to human CD4 and one directed to the a-chain of the human interleukin-2 receptor [PDF]

, 1992
The general feasibility of chimerization of monoclonal antibodies (mAbs) has already been shown for a large number of them. In order to evaluate in vitro parameters relevant to immunosuppressive therapy, we have chimerized and synthesized two anti-CD4 ...
Flieger, Dimitri, Kaluzab, Brigitte, Lenz, Helmut, Reiter, Christian, Rieber, Ernst Peter, Riethmüller, Gert, Scheuer, Werner, Schwirzke, Marina, Weidle, Ulrich H., Weiss, Elisabeth H., Weissenhorn, Winfried   +10 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Picoliter-volume inkjet printing into planar microdevice reservoirs for low-waste, high-capacity drug loading. [PDF]

, 2017
Oral delivery of therapeutics is the preferred route for systemic drug administration due to ease of access and improved patient compliance. However, many therapeutics suffer from low oral bioavailability due to low pH and enzymatic conditions, poor ...
Bogdanoff, Derek B, Cantlon, Joshua, Chevalier, Rachel W, Desai, Tejal A, Fox, Cade B, Hsiao, Jeff C, Nemeth, Cameron L   +6 more
core   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Non-agonistic bivalent antibodies that promote c-MET degradation and inhibit tumor growth and others specific for tumor related c-MET.

PLoS ONE, 2012
The c-MET receptor has a function in many human cancers and is a proven therapeutic target. Generating antagonistic or therapeutic monoclonal antibodies (mAbs) targeting c-MET has been difficult because bivalent, intact anti-Met antibodies frequently ...
Sameer A Greenall, Ermanno Gherardi, Zhanqi Liu, Jacqueline F Donoghue, Angela A Vitali, Qian Li, Roger Murphy, Luisa Iamele, Andrew M Scott, Terrance G Johns   +9 more
doaj   +1 more source

Optical fiber tactile sensor [PDF]

, 1983
A tactile sensor comprises an array of cells which are covered by an elastic membrane, having an exposed surface which is adapted to come in contact with an object.
Bejczy, A. K.
core   +1 more source

Development and characterisation of lithographically printed voltaic cells [PDF]

, 2006
This paper reports progress in the fabrication of voltaic cells and batteries via offset lithographic printing. Successful design and manufacture of lithographically printed voltaic cells would facilitate the integration of printed passive components ...
Evans, PSA, Harrison, DJ, Hay, GI, Southee, DJ   +3 more
core   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Sensitive methods for estimating the anchoring strength of nematic liquid crystals on Langmuir-Blodgett monolayers of fatty acids

, 2001
The anchoring of the nematic liquid crystal N-(p-methoxybenzylidene)-p-butylaniline (MBBA) on Langmuir-Blodgett monolayers of fatty acids (COOHC$_{n}$H$_{2n+1}$) was studied as a function of the length of the fatty acid alkyl chains, $n$ ($n = 15, 17, 19,
A. A. Sonin, A. L. Alexe-Ionescu, A. L. Alexe-Ionescu, A. Rapini, B. Jérôme, D. E. Lucchetta, Francesca Nannelli, G. Barbero, G. Strangi, H. Yokohama, K. Hiltorp, L. M. Blinov, Lachezar Komitov, M. C. Petty, N. Scaramuzza, S. A. Pikin, V. S. U. Fazio, V. S. U. Fazio, V. S. U. Fazio, Valentina S. U. Fazio   +19 more
core   +1 more source