Results 171 to 180 of about 3,358,181 (305)

Regulation of stress tolerance by CREB1 sustains multiple myeloma cell survival. [PDF]

Cell Death Dis
Kudalkar R, Altom J, Galloway J, Manning V, Taranto S, Cottini F.   +5 more
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

MIZ-1 controls transcriptional programs required for BCR signaling, actin dynamics, and naïve B cell survival. [PDF]

Front Immunol
Ross J, Piskor EM, Joly-Beauparlant C, Tabarez LPG, El Ghorayeb E, Droit A, Kosan C, Möröy T.   +7 more
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

KLF5 controls subtype-independent highly interactive enhancers in pancreatic cancer to regulate cell survival. [PDF]

Sci Adv
Ekstrom TL, Dai Z, Thiel J, Kanakan A, Saha BJ, Manjunath M, Schacherer N, Bousounis P, Siegler EL, Abdelrahman AM, Souto Y, Essmann F, Najafova Z, Beyes S, Truty MJ, Dong M, Johnsen SA.   +16 more
europepmc   +1 more source

Nerve Cell Survival [PDF]

, 2020
openaire   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Intracellular Oxidant Levels Are Crucial for Cell Survival and JAK/STAT Signaling in Classical Hodgkin's Lymphoma. [PDF]

Antioxidants (Basel)
Wildfeuer J, Dheenadayalan RP, Hartung S, Zahn M, Albrecht TP, Cao Z, Ushmorov A, Möller P, Gaisa NT, Marienfeld R.   +9 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Reduced SUMOylation impairs NOTCH3 signaling and cell survival in the pathogenesis of CADASIL. [PDF]

Cell Commun Signal
Long L, Wu D, Xiong X, Xiong H, Qiu X, Ping S.   +5 more
europepmc   +1 more source